Crosstalk between HSPA5 arginylation and sequential ubiquitination leads to AKT degradation through autophagy flux

AKT as a Therapeutic Target for Cancer

(2019) Mengqiu Song et al.   CANCER RESEARCH

HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer

(2018) Sun-Yong Kim et al.   Autophagy

PARK7 modulates autophagic proteolysis through binding to the N-terminally arginylated form of the molecular chaperone HSPA5

(2018) Dae-Hee Lee et al.   Autophagy

Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma

(2018) Reinaldo Franqui-Machin et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional characterization of lysosomal interaction of Akt with VRK2

(2018) Noriyuki Hirata et al.   ONCOGENE

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

(2018) Fumiaki Ohtake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The critical role of AMPK in driving Akt activation under stress, tumorigenesis and drug resistance

(2018) Fei Han et al.   Nature Communications

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

(2017) Chao Liu et al.   Nature Communications

Modulation of SQSTM1/p62 activity by N-terminal arginylation of the endoplasmic reticulum chaperone HSPA5/GRP78/BiP

(2016) Hyunjoo Cha-Molstad et al.   Autophagy

Ubiquitin versus misfolding: The minimal requirements for inclusion body formation

(2016) Nico P. Dantuma et al.   JOURNAL OF CELL BIOLOGY

Sequential Poly-ubiquitylation by Specialized Conjugating Enzymes Expands the Versatility of a Quality Control Ubiquitin Ligase

(2016) Annika Weber et al.   MOLECULAR CELL

Structural insights into the catalysis and regulation of E3 ubiquitin ligases

(2016) Lori Buetow et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A First-in-Human Phase I Study of the ATP-Competitive AKT Inhibitor Ipatasertib Demonstrates Robust and Safe Targeting of AKT in Patients with Solid Tumors

(2016) Cristina Saura et al.   Cancer Discovery

Mitochondrial outer-membrane E3 ligase MUL1 ubiquitinates ULK1 and regulates selenite-induced mitophagy

(2015) Jie Li et al.   Autophagy

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

(2015) C. Larrue et al.   BLOOD

Pharmacologic screens reveal metformin that suppresses GRP78-dependent autophagy to enhance the anti-myeloma effect of bortezomib

(2015) S Jagannathan et al.   LEUKEMIA

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

(2015) Esperanza Arias et al.   MOLECULAR CELL

Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding

(2015) Hyunjoo Cha-Molstad et al.   NATURE CELL BIOLOGY

Sequential ubiquitination and deubiquitination enzymes synchronize the dual sensor and effector functions of TRIM21

(2015) Adam J. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Substrate degradation by the proteasome: A single-molecule kinetic analysis

(2015) Y. Lu et al.   SCIENCE

Non-thermal plasma induces AKT degradation through turn-on the MUL1 E3 ligase in head and neck cancer

(2015) Sun-Yong Kim et al.   Oncotarget

The novel AKT inhibitor afuresertib shows favorable safety, pharmacokinetics, and clinical activity in multiple myeloma

(2014) A. Spencer et al.   BLOOD

Selective and Potent Akt Inhibition Triggers Anti-Myeloma Activities and Enhances Fatal Endoplasmic Reticulum Stress Induced by Proteasome Inhibition

(2014) N. Mimura et al.   CANCER RESEARCH

Lysosomal Interaction of Akt with Phafin2: A Critical Step in the Induction of Autophagy

(2014) Mami Matsuda-Lennikov et al.   PLoS One

Radiation-Induced Autophagy Contributes to Cell Death and Induces Apoptosis Partly in Malignant Glioma Cells

(2014) Guk Heui Jo et al.   Cancer Research and Treatment

Redox signaling via the molecular chaperone BiP protects cells against endoplasmic reticulum-derived oxidative stress

(2014) Jie Wang et al.   eLife

Akt SUMOylation Regulates Cell Proliferation and Tumorigenesis

(2013) R. Li et al.   CANCER RESEARCH

Proteasome inhibitors in multiple myeloma: 10 years later

(2012) P. Moreau et al.   BLOOD

Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1

(2012) J. Fang et al.   BLOOD

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance

(2012) Dharminder Chauhan et al.   CANCER CELL

Akt is negatively regulated by the MULAN E3 ligase

(2012) Seunghee Bae et al.   CELL RESEARCH

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Regulation of Akt signaling activation by ubiquitination

(2010) Wei-Lei Yang et al.   CELL CYCLE

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

GRP-78 secreted by tumor cells blocks the antiangiogenic activity of bortezomib

(2009) J. Kern et al.   BLOOD

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

(2009) M Wang et al.   CELL DEATH AND DIFFERENTIATION

The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

(2009) Futoshi Suizu et al.   DEVELOPMENTAL CELL

A Role for Ubiquitin in Selective Autophagy

(2009) Vladimir Kirkin et al.   MOLECULAR CELL

Negative Regulation of AKT Activation by BRCA1

(2008) T. Xiang et al.   CANCER RESEARCH

The unfolded protein response regulator GRP78/BiP is required for endoplasmic reticulum integrity and stress-induced autophagy in mammalian cells

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth

(2008) Bicheng Zhang et al.   CELL RESEARCH