Human tyrosine hydroxylase in Parkinson’s disease and in related disorders

Toxic properties of microsome-associated alpha-synuclein species in mouse primary neurons

(2018) Emanuela Colla et al.   NEUROBIOLOGY OF DISEASE

Aminochrome Induces Irreversible Mitochondrial Dysfunction by Inducing Autophagy Dysfunction in Parkinson's Disease

(2018) Juan Segura-Aguilar et al.   Frontiers in Neuroscience

Inhibition of deubiquitinating activity of USP14 decreases tyrosine hydroxylase phosphorylated at Ser19 in PC12D cells

(2016) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Copy number variability in Parkinson’s disease: assembling the puzzle through a systems biology approach

(2016) Valentina La Cognata et al.   HUMAN GENETICS

Proteasome-mediated degradation of tyrosine hydroxylase triggered by its phosphorylation: a new question as to the intracellular location at which the degradation occurs

(2016) Akira Nakashima et al.   JOURNAL OF NEURAL TRANSMISSION

Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson’s disease (PD): historical overview and future prospects

(2016) Toshiharu Nagatsu et al.   JOURNAL OF NEURAL TRANSMISSION

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Generation of an iPSC line from a patient with tyrosine hydroxylase (TH) deficiency: TH-1 iPSC

(2016) Sabine Jung-Klawitter et al.   Stem Cell Research

Optimizing Transgene Configuration and Protein Fusions to Maximize Dopamine Production for the Gene Therapy of Parkinson's Disease

(2016) Hannah J. Stewart et al.   Human Gene Therapy Clinical Development

Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme

(2016) Maria T. Bezem et al.   Scientific Reports

Dopamine or biopterin deficiency potentiates phosphorylation at 40 Ser and ubiquitination of tyrosine hydroxylase to be degraded by the ubiquitin proteasome system

(2015) Ichiro Kawahata et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural insights into the regulation of aromatic amino acid hydroxylation

(2015) Paul F Fitzpatrick   CURRENT OPINION IN STRUCTURAL BIOLOGY

Benefits of Neuronal Preferential Systemic Gene Therapy for Neurotransmitter Deficiency

(2015) Ni-Chung Lee et al.   MOLECULAR THERAPY

Tyrosine Hydroxylase Is Short-Term Regulated by the Ubiquitin-Proteasome System in PC12 Cells and Hypothalamic and Brainstem Neurons from Spontaneously Hypertensive Rats: Possible Implications in Hypertension

(2015) Nadia A. Longo Carbajosa et al.   PLoS One

Functional Studies of Tyrosine Hydroxylase Missense Variants Reveal Distinct Patterns of Molecular Defects in Dopa-Responsive Dystonia

(2014) Agnete Fossbakk et al.   HUMAN MUTATION

Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial

(2014) Stéphane Palfi et al.   LANCET

The medical treatment of Parkinson disease from James Parkinson to George Cotzias

(2014) Stanley Fahn   MOVEMENT DISORDERS

Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

(2014) Daisuke Doi et al.   Stem Cell Reports

The Solution Structure of the Regulatory Domain of Tyrosine Hydroxylase

(2013) Shengnan Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson's disease

(2013) David S. Goldstein et al.   JOURNAL OF NEUROCHEMISTRY

Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

(2013) Asuka Morizane et al.   Stem Cell Reports

Tyrosine Hydroxylase Gene: Another Piece of the Genetic Puzzle of Parkinson’s Disease

(2012) Guney Bademci et al.   CNS & Neurological Disorders-Drug Targets

A possible pathophysiological role of tyrosine hydroxylase in Parkinson’s disease suggested by postmortem brain biochemistry: a contribution for the special 70th birthday symposium in honor of Prof. Peter Riederer

(2012) Akira Nakashima et al.   JOURNAL OF NEURAL TRANSMISSION

Phosphorylation of the N-terminal portion of tyrosine hydroxylase triggers proteasomal digestion of the enzyme

(2011) Akira Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Tyrosine hydroxylase and regulation of dopamine synthesis

(2010) S. Colette Daubner et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis

(2010) M. A. Willemsen et al.   BRAIN

Hereditary progressive dystonia with marked diurnal fluctuation

(2010) Masaya Segawa   BRAIN & DEVELOPMENT

A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease

(2010) Güney Bademci et al.   HUMAN MUTATION

Human DJ-1-specific Transcriptional Activation of Tyrosine Hydroxylase Gene

(2010) Shizuma Ishikawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease

(2010) Shin-ichi Muramatsu et al.   MOLECULAR THERAPY

Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia

(2009) F. Clot et al.   BRAIN

Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin–proteasome system in PC12D cells

(2009) Ichiro Kawahata et al.   JOURNAL OF NEURAL TRANSMISSION

L-dopa therapy for Parkinson's disease: Past, present, and future

(2009) Toshiharu Nagatsu et al.   PARKINSONISM & RELATED DISORDERS

Catecholaminergic Systems in Stress: Structural and Molecular Genetic Approaches

(2009) Richard Kvetnansky et al.   PHYSIOLOGICAL REVIEWS

Common and rare variants in multifactorial susceptibility to common diseases

(2008) Walter Bodmer et al.   NATURE GENETICS

Results from a phase I safety trial of hAADC gene therapy for Parkinson disease

(2008) J. L. Eberling et al.   NEUROLOGY