Hepatocyte-specific deletion of small heterodimer partner protects mice against acetaminophen-induced hepatotoxicity via activation of Nrf2

c-Jun-N Terminal Kinase-Mediated Degradation of γ-Glutamylcysteine Ligase Catalytic Subunit Inhibits GSH Recovery After Acetaminophen Treatment: Role in Sustaining JNK Activation and Liver Injury

(2022) Sanda Win et al.   ANTIOXIDANTS & REDOX SIGNALING

Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring

(2021) Arthur David et al.   ENVIRONMENT INTERNATIONAL

The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease

(2021) Jianguo Wu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver

(2021) Bhoomika Mathur et al.   Science Advances

JNK Phosphorylates The Neh6 Domain Of Nrf2 And Downregulates Cytoprotective Genes In Acetaminophen‐Induced Liver Injury

(2020) Yiping Chen et al.   HEPATOLOGY

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

(2020) Liam Baird et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice

(2020) Nga T. Nguyen et al.   TOXICOLOGY LETTERS

Delayed Treatment with 4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun N-Terminal Kinase

(2019) Jephte Y Akakpo et al.   TOXICOLOGICAL SCIENCES

Hepatocyte SHP deficiency protects mice from acetaminophen-evoked liver injury in a JNK-signaling regulation and GADD45β-dependent manner

(2018) Yong-Hoon Kim et al.   ARCHIVES OF TOXICOLOGY

4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

(2018) JY Akakpo et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis

(2018) An Zou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

(2018) Mingzhu Yan et al.   Redox Biology

The protective role of Nrf2-Gadd45b against antimony-induced oxidative stress and apoptosis in HEK293 cells

(2016) Xingkang Jiang et al.   TOXICOLOGY LETTERS

Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

(2016) Kuo Du et al.   Redox Biology

Pathophysiological significance of c-junN-terminal kinase in acetaminophen hepatotoxicity

(2015) Kuo Du et al.   Expert Opinion on Drug Metabolism & Toxicology

Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase

(2014) Kuo Du et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Mechanisms of acetaminophen-induced cell death in primary human hepatocytes

(2014) Yuchao Xie et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Role of Bile Acids in Liver Injury and Regeneration following Acetaminophen Overdose

(2013) Bharat Bhushan et al.   AMERICAN JOURNAL OF PATHOLOGY

Drug-induced Acute Liver Failure

(2013) William M. Lee   Clinics in Liver Disease

Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

(2013) Mitchell R. McGill et al.   PHARMACEUTICAL RESEARCH

Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: Dose–response, mechanisms, and clinical implications

(2013) Mitchell R. McGill et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

The high Nrf2 expression in human acute myeloid leukemia is driven by NF- B and underlies its chemo-resistance

(2012) S. A. Rushworth et al.   BLOOD

Acetaminophen and acetylcysteine dose and duration: Past, present and future

(2012) Barry H Rumack et al.   CLINICAL TOXICOLOGY

A Review of Acetaminophen Poisoning

(2012) Michael J. Hodgman et al.   CRITICAL CARE CLINICS

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

Endogenous Interleukin-4 Regulates Glutathione Synthesis Following Acetaminophen-Induced Liver Injury in Mice

(2011) Pauline M. Ryan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors

(2011) Jae-Min Yuk et al.   NATURE IMMUNOLOGY

Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism

(2010) Jiansheng Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Role of nuclear receptor SHP in metabolism and cancer

(2010) Yuxia Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis

(2010) Deepti Malhotra et al.   NUCLEIC ACIDS RESEARCH

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

(2009) Daniel J. Antoine et al.   TOXICOLOGICAL SCIENCES

Molecular Basis of Endocrine Regulation by Orphan Nuclear Receptor Small Heterodimer Partner

(2008) Dipanjan CHANDA et al.   ENDOCRINE JOURNAL

Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation

(2008) Yuxia Zhang et al.   HEPATOLOGY

Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury

(2008) Naoko Hanawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

(2007) Lauren M. Aleksunes et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY