Better safe than sorry: Naive T-cell dynamics in healthy ageing

Quantifying cellular dynamics in mice using a novel fluorescent division reporter system

(2023) Eva Lukas et al.   Frontiers in Immunology

Primary immune responses are negatively impacted by persistent herpesvirus infections in older people: results from an observational study on healthy subjects and a vaccination trial on subjects aged more than 70 years old

(2022) Francesco Nicoli et al.   EBioMedicine

Towards a unified model of naive T cell dynamics across the lifespan

(2022) Sanket Rane et al.   eLife

Hallmarks of the aging T‐cell system

(2021) Huimin Zhang et al.   FEBS Journal

TCRβ rearrangements without a D segment are common, abundant, and public

(2021) Peter C. de Greef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of immune aging on vaccine responses

(2020) Claire E. Gustafson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The naive T-cell receptor repertoire has an extremely broad distribution of clone sizes

(2020) Peter C de Greef et al.   eLife

How deadly is the coronavirus? Scientists are close to an answer

(2020) Smriti Mallapaty   NATURE

How age and infection history shape the antigen‐specific CD8 + T‐cell repertoire: Implications for vaccination strategies in older adults

(2020) Josien Lanfermeijer et al.   AGING CELL

Early life imprints the hierarchy of T cell clone sizes

(2020) Mario U Gaimann et al.   eLife

Cell generation dynamics underlying naive T-cell homeostasis in adult humans

(2019) Jeff E. Mold et al.   PLOS BIOLOGY

Differential impact of self and environmental antigens on the ontogeny and maintenance of CD4+ T cell memory

(2019) Thea Hogan et al.   eLife

Age is not just a number: Naive T cells increase their ability to persist in the circulation over time

(2018) Sanket Rane et al.   PLOS BIOLOGY

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

(2018) Evgeny S. Egorov et al.   Frontiers in Immunology

Aging-related changes in human T-cell repertoire over 20 years delineated by deep sequencing of peripheral T-cell receptors

(2017) Kengo Yoshida et al.   EXPERIMENTAL GERONTOLOGY

Comparative analysis of murine T-cell receptor repertoires

(2017) Mark Izraelson et al.   IMMUNOLOGY

Immunosequencing identifies signatures of cytomegalovirus exposure history and HLA-mediated effects on the T cell repertoire

(2017) Ryan O Emerson et al.   NATURE GENETICS

Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires

(2017) Mikhail V. Pogorelyy et al.   PLoS Computational Biology

Memory CD4 T cell subsets are kinetically heterogeneous and replenished from naive T cells at high levels

(2017) Graeme Gossel et al.   eLife

Lymphocyte maintenance during healthy aging requires no substantial alterations in cellular turnover

(2015) Liset Westera et al.   AGING CELL

Quantification of naive and memory T-cell turnover during HIV-1 infection

(2015) Nienke Vrisekoop et al.   AIDS

Temporal fate mapping reveals age-linked heterogeneity in naive T lymphocytes in mice

(2015) Thea Hogan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Magnitude of Thymic Output Is Genetically Determined through Controlled Intrathymic Precursor T Cell Proliferation

(2014) G. Dulude et al.   JOURNAL OF IMMUNOLOGY

Homeostasis of the Naive CD4+ T Cell Compartment during Aging

(2014) R. D. Kilpatrick et al.   JOURNAL OF IMMUNOLOGY

Restoration of the CD4 T Cell Compartment after Long-Term Highly Active Antiretroviral Therapy without Phenotypical Signs of Accelerated Immunological Aging

(2014) N. Vrisekoop et al.   JOURNAL OF IMMUNOLOGY

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Aging and Cytomegalovirus Infection Differentially and Jointly Affect Distinct Circulating T Cell Subsets in Humans

(2014) A. M. Wertheimer et al.   JOURNAL OF IMMUNOLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral memory phenotype T cells in unexposed adults

(2013) Laura F. Su et al.   IMMUNOLOGICAL REVIEWS

Maintenance of Peripheral Naive T Cells Is Sustained by Thymus Output in Mice but Not Humans

(2012) Ineke den Braber et al.   IMMUNITY

Lymphopenia-Driven Homeostatic Regulation of Naive T Cells in Elderly and Thymectomized Young Adults

(2012) D. Sauce et al.   JOURNAL OF IMMUNOLOGY

Long-term restoration of the human T-cell compartment after thymectomy during infancy: a role for thymic regeneration?

(2011) R. van Gent et al.   BLOOD

Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis

(2011) Michael T Osterholm et al.   LANCET INFECTIOUS DISEASES

CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or γδ T-cells, in HIV patients responding to ART

(2010) Sara Tanaskovic et al.   IMMUNOLOGY AND CELL BIOLOGY

Quantifying the development of the peripheral naive CD4+ T-cell pool in humans

(2009) I. Bains et al.   BLOOD

Human CD4+T cell recent thymic emigrants are identified by protein tyrosine kinase 7 and have reduced immune function

(2009) Christopher J. Haines et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Quantifying Thymic Export: Combining Models of Naive T Cell Proliferation and TCR Excision Circle Dynamics Gives an Explicit Measure of Thymic Output

(2009) I. Bains et al.   JOURNAL OF IMMUNOLOGY

Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects

(2009) H. Tsukamoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thymectomy in early childhood: Significant alterations of the CD4+CD45RA+CD62L+ T cell compartment in later life

(2008) Martina Prelog et al.   CLINICAL IMMUNOLOGY

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Determination of thymic function directly from peripheral blood: A validated modification to an established method

(2008) A.R. Lorenzi et al.   JOURNAL OF IMMUNOLOGICAL METHODS