Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer

Autophagy-dependent ferroptosis in cancer

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GPX4 in cell death, autophagy, and disease

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Immunogenic cell stress and death

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Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis

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HSP90 Mediates IFNγ-Induced Adaptive Resistance to Anti-PD-1 Immunotherapy

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Mitochondrial glutathione peroxidase 4 is indispensable for photoreceptor development and survival in mice

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TMEM164 is a new determinant of autophagy-dependent ferroptosis

(2022) Jiao Liu et al.   Autophagy

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

(2022) Bartosz Wiernicki et al.   Nature Communications

Ferroptosis of tumour neutrophils causes immune suppression in cancer

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Tumor heterogeneity in autophagy-dependent ferroptosis

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Characteristics and Biomarkers of Ferroptosis

(2021) Xin Chen et al.   Frontiers in Cell and Developmental Biology

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

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Broadening horizons: the role of ferroptosis in cancer

(2021) Xin Chen et al.   Nature Reviews Clinical Oncology

Beyond immune checkpoint blockade: emerging immunological strategies

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NUPR1 is a critical repressor of ferroptosis

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E3 ligase TRIM25 ubiquitinates RIP3 to inhibit TNF induced cell necrosis

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TRIM25 regulates oxaliplatin resistance in colorectal cancer by promoting EZH2 stability

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Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

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PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

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AIFM2 blocks ferroptosis independent of ubiquinol metabolism

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TRIM25 Promotes TNF-α–induced NF-κB Activation through Potentiating the K63-Linked Ubiquitination of TRAF2

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Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway

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Acquired Resistance to Immune Checkpoint Inhibitors

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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

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Targeting apoptosis in cancer therapy

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

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Lifting the innate immune barriers to antitumor immunity

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Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

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Ferroptosis: machinery and regulation

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Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1

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Blockade of miR-3614 maturation by IGF2BP3 increases TRIM25 expression and promotes breast cancer cell proliferation

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Chaperone-mediated autophagy is involved in the execution of ferroptosis

(2019) Zheming Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The release and activity of HMGB1 in ferroptosis

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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

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Mechanisms of resistance to immune checkpoint inhibitors

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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis

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Highly Efficient and Versatile Plasmid-Based Gene Editing in Primary T Cells

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TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer

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Cancer immunotherapy using checkpoint blockade

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PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism

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Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins

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Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

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An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis

(2017) Logan A. Walsh et al.   Cell Reports

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

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Autophagy promotes ferroptosis by degradation of ferritin

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Ferroptosis: process and function

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Ferroptosis is an autophagic cell death process

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

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TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-β signaling

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Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway

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Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration

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Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

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Releasing the Brakes on Cancer Immunotherapy

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

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MD-2 is required for disulfide HMGB1–dependent TLR4 signaling

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Ferroptosis as a p53-mediated activity during tumour suppression

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Regulation of Ferroptotic Cancer Cell Death by GPX4

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Overview of Proteasome Inhibitor-Based Anti-cancer Therapies: Perspective on Bortezomib and Second Generation Proteasome Inhibitors versus Future Generation Inhibitors of Ubiquitin-Proteasome System

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

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Intracellular Hmgb1 Inhibits Inflammatory Nucleosome Release and Limits Acute Pancreatitis in Mice

(2013) Rui Kang et al.   GASTROENTEROLOGY

Genome engineering using the CRISPR-Cas9 system

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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

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Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

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Hallmarks of Cancer: The Next Generation

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HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

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Immunogenic death of colon cancer cells treated with oxaliplatin

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Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

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