A PSD-95 peptidomimetic mitigates neurological deficits in a mouse model of Angelman syndrome

UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways

(2023) Xiaoning Hao et al.   EXPERIMENTAL NEUROLOGY

Molecular mechanisms of AMPAR reversible stabilization at synapses

(2023) Diogo Bessa-Neto et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice

(2022) Emmanouela Kallergi et al.   Nature Communications

CaMKII: a central molecular organizer of synaptic plasticity, learning and memory

(2022) Ryohei Yasuda et al.   NATURE REVIEWS NEUROSCIENCE

UBE3A reinstatement as a disease‐modifying therapy for Angelman syndrome

(2021) Ype Elgersma et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Functional rescue in an Angelman syndrome model following treatment with lentivector transduced hematopoietic stem cells

(2021) Anna Adhikari et al.   HUMAN MOLECULAR GENETICS

NMDAR-dependent long-term depression is associated with increased short term plasticity through autophagy mediated loss of PSD-95

(2021) Benjamin Compans et al.   Nature Communications

Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model

(2021) Claudia Milazzo et al.   JCI Insight

Potassium channel dysfunction in human neuronal models of Angelman syndrome

(2020) Alfred Xuyang Sun et al.   SCIENCE

Intellectual and Developmental Disabilities Research Centers: A Multidisciplinary Approach to Understand the Pathogenesis of Methyl-CpG Binding Protein 2-related Disorders

(2020) Michela Fagiolini et al.   NEUROSCIENCE

Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA

(2020) Justin M. Wolter et al.   NATURE

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Sex-Dependent Sensory Phenotypes and Related Transcriptomic Expression Profiles Are Differentially Affected by Angelman Syndrome

(2019) Lee Koyavski et al.   MOLECULAR NEUROBIOLOGY

Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation

(2019) Yin Cao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Behavioral Evaluation of Angelman Syndrome Mice at Older Ages

(2019) Rebecca Dutta et al.   NEUROSCIENCE

Estrogen deficiency induces memory loss via altered hippocampal HB-EGF and autophagy

(2019) Rukmani Pandey et al.   JOURNAL OF ENDOCRINOLOGY

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

HAP1 is an in vivo UBE3A target that augments autophagy in a mouse model of Angelman syndrome

(2019) Tingting Wang et al.   NEUROBIOLOGY OF DISEASE

Autophagy Enhances Memory Erasure through Synaptic Destabilization

(2018) Mohammad Shehata et al.   JOURNAL OF NEUROSCIENCE

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus

(2018) John Marshall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation and Roles of Autophagy at Synapses

(2018) Vassiliki Nikoletopoulou et al.   TRENDS IN CELL BIOLOGY

Genetic Dissection of Presynaptic and Postsynaptic BDNF-TrkB Signaling in Synaptic Efficacy of CA3-CA1 Synapses

(2018) Pei-Yi Lin et al.   Cell Reports

A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants

(2018) Monica Sonzogni et al.   Molecular Autism

Modulation of AMPA receptor surface diffusion restores hippocampal plasticity and memory in Huntington’s disease models

(2018) Hongyu Zhang et al.   Nature Communications

Effect of early postnatal exposure to valproate on neurobehavioral development and regional BDNF expression in two strains of mice

(2017) Kevin G. Bath et al.   EPILEPSY & BEHAVIOR

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A role for autophagy in long-term spatial memory formation in male rodents

(2017) Michael J. Hylin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Bassoon Controls Presynaptic Autophagy through Atg5

(2017) Nathan D. Okerlund et al.   NEURON

Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells

(2017) James J. Fink et al.   Nature Communications

Activity-Dependent Arc Expression and Homeostatic Synaptic Plasticity Are Altered in Neurons from a Mouse Model of Angelman Syndrome

(2017) Elissa D. Pastuzyn et al.   Frontiers in Molecular Neuroscience

TrkB-enhancer facilitates functional recovery after traumatic brain injury

(2017) John Marshall et al.   Scientific Reports

mTORC1–S6K1 inhibition or mTORC2 activation improves hippocampal synaptic plasticity and learning in Angelman syndrome mice

(2016) Jiandong Sun et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The Role of BDNF in the Development of Fear Learning

(2016) Iva Dincheva et al.   DEPRESSION AND ANXIETY

Autophagy activation involved in hypoxic-ischemic brain injury induces cognitive and memory impairment in neonatal rats

(2016) Ying Xu et al.   JOURNAL OF NEUROCHEMISTRY

Protein Delivery of an Artificial Transcription Factor Restores Widespread Ube3a Expression in an Angelman Syndrome Mouse Brain

(2016) Barbara J Bailus et al.   MOLECULAR THERAPY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Function and Mechanisms of Autophagy in Brain and Spinal Cord Trauma

(2015) Marta M. Lipinski et al.   ANTIOXIDANTS & REDOX SIGNALING

Dissociation of locomotor and cerebellar deficits in a murine Angelman syndrome model

(2015) Caroline F. Bruinsma et al.   JOURNAL OF CLINICAL INVESTIGATION

Ube3a reinstatement identifies distinct developmental windows in a murine Angelman syndrome model

(2015) Sara Silva-Santos et al.   JOURNAL OF CLINICAL INVESTIGATION

Imbalanced Mechanistic Target of Rapamycin C1 and C2 Activity in the Cerebellum of Angelman Syndrome Mice Impairs Motor Function

(2015) J. Sun et al.   JOURNAL OF NEUROSCIENCE

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration

(2014) David Heras-Sandoval et al.   CELLULAR SIGNALLING

BDNF Modulates Contextual Fear Learning during Adolescence

(2014) Iva Dincheva et al.   DEVELOPMENTAL NEUROSCIENCE

Rapamycin and Interleukin-1β Impair Brain-derived Neurotrophic Factor-dependent Neuron Survival by Modulating Autophagy

(2014) Erica D. Smith et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Super-Ecliptic, pHluorin-mKate2, Tandem Fluorescent Protein-Tagged Human LC3 for the Monitoring of Mammalian Autophagy

(2014) Isei Tanida et al.   PLoS One

Behavioral deficits in an Angelman syndrome model: Effects of genetic background and age

(2013) Hsien-Sung Huang et al.   BEHAVIOURAL BRAIN RESEARCH

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

(2013) Cong Cao et al.   PLOS BIOLOGY

Reversal of Impaired Hippocampal Long-Term Potentiation and Contextual Fear Memory Deficits in Angelman Syndrome Model Mice by ErbB Inhibitors

(2012) Hanoch Kaphzan et al.   BIOLOGICAL PSYCHIATRY

Defective glucocorticoid hormone receptor signaling leads to increased stress and anxiety in a mouse model of Angelman syndrome

(2012) Swetha K. Godavarthi et al.   HUMAN MOLECULAR GENETICS

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

(2011) Jennifer L. Daily et al.   PLoS One

Sociability and motor functions in Shank1 mutant mice

(2010) Jill L. Silverman et al.   BRAIN RESEARCH

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging

(2010) H. A. Boger et al.   GENES BRAIN AND BEHAVIOR

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin

(2010) Patricio Opazo et al.   NEURON

Altered Ultrasonic Vocalization and Impaired Learning and Memory in Angelman Syndrome Mouse Model with a Large Maternal Deletion from Ube3a to Gabrb3

(2010) Yong-hui Jiang et al.   PLoS One

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome

(2009) Hailing Su et al.   NEUROSCIENCE LETTERS