Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation

Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models

(2018) Jia Liu et al.   Autophagy

Lycium barbarum polysaccharide protects against oxygen glucose deprivation/reoxygenation-induced apoptosis and autophagic cell death via the PI3K/Akt/mTOR signaling pathway in primary cultured hippocampal neurons

(2018) Yang Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Trillium tschonoskii maxim saponin mitigates D-galactose-induced brain aging of rats through rescuing dysfunctional autophagy mediated by Rheb-mTOR signal pathway

(2018) Lingjie Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Dopamine Receptor Subtypes Differentially Regulate Autophagy

(2018) Dongmei Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation

(2018) Chiara Vidoni et al.   NEUROCHEMISTRY INTERNATIONAL

Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior

(2018) Dong Sun et al.   Cell Death & Disease

Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice

(2017) Wei Liu et al.   JOURNAL OF ETHNOPHARMACOLOGY

A role for autophagy in long-term spatial memory formation in male rodents

(2017) Michael J. Hylin et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Rapamycin inhibits mTOR/p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory

(2017) D. Lana et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY

(2017) Simon D Harding et al.   NUCLEIC ACIDS RESEARCH

Rapamycin prevents cerebral stroke by modulating apoptosis and autophagy in penumbra in rats

(2017) Meiling Wu et al.   Annals of Clinical and Translational Neurology

Modafinil Prevents Inhibitory Avoidance Memory Deficit Induced by Sleep Deprivation in Rats

(2017) Karin Monteiro Moreira et al.   SLEEP

Protective Effect of Silibinin on Learning and Memory Impairment in LPS-Treated Rats via ROS–BDNF–TrkB Pathway

(2016) Xiaoyu Song et al.   NEUROCHEMICAL RESEARCH

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Impaired autophagy: a link between neurodegenerative and neuropsychiatric diseases

(2014) Mira Polajnar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model

(2014) T. Zhang et al.   NEUROSCIENCE

Gambogenic Acid Kills Lung Cancer Cells through Aberrant Autophagy

(2014) Wang Mei et al.   PLoS One

Sleep deprivation induces differential morphological changes in the hippocampus and prefrontal cortex in young and old rats

(2014) Eva Acosta-peña et al.   SYNAPSE

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sleep and synaptic changes

(2013) Chiara Cirelli   CURRENT OPINION IN NEUROBIOLOGY

Caffeine and modafinil promote adult neuronal cell proliferation during 48h of total sleep deprivation in rat dentate gyrus

(2013) Surajit Sahu et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective effect of brain-derived neurotrophic factor mediated by autophagy through the PI3K/Akt/mTOR pathway

(2013) AI CHEN et al.   Molecular Medicine Reports

Modafinil as a Catecholaminergic Agent: Empirical Evidence and Unanswered Questions

(2013) Jonathan Wisor   Frontiers in Neurology

Beclin1: A role in membrane dynamics and beyond

(2012) Ellen Wirawan et al.   Autophagy

R-Modafinil (Armodafinil): A Unique Dopamine Uptake Inhibitor and Potential Medication for Psychostimulant Abuse

(2012) Claus J. Loland et al.   BIOLOGICAL PSYCHIATRY

Modafinil improves event related potentials P300 and contingent negative variation after 24h sleep deprivation

(2012) Koushik Ray et al.   LIFE SCIENCES

Modafinil Abrogates Methamphetamine-Induced Neuroinflammation and Apoptotic Effects in the Mouse Striatum

(2012) Mariana Raineri et al.   PLoS One

Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression

(2011) Bin He et al.   BRAIN RESEARCH

The cognitive cost of sleep lost

(2011) John G. McCoy et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde

(2010) Heng Ma et al.   EUROPEAN HEART JOURNAL

Functions and regulation of the 70kDa ribosomal S6 kinases

(2010) Tim R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Modafinil on Impairments in Neurobehavioral Performance and Learning Associated with Extended Wakefulness and Circadian Misalignment

(2010) Scott Grady et al.   NEUROPSYCHOPHARMACOLOGY

Differential effects of total sleep deprivation on contextual and spatial memory: Modulatory effects of modafinil

(2010) Christophe Pierard et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway: Figure 1

(2009) Yu-Yun Chang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of Autophagy Induction Delays Neuronal Cell Loss Caused by Dysfunctional ESCRT-III in Frontotemporal Dementia

(2009) J.-A Lee et al.   JOURNAL OF NEUROSCIENCE

Autophagy: A lysosomal degradation pathway with a central role in health and disease

(2008) Eeva-Liisa Eskelinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy

(2008) X. Zeng et al.   CANCER RESEARCH

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Systemic inhibition of mammalian target of rapamycin inhibits fear memory reconsolidation

(2008) Jacqueline Blundell et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

New neurons in the adult brain: The role of sleep and consequences of sleep loss

(2008) Peter Meerlo et al.   SLEEP MEDICINE REVIEWS