CaMKII: a central molecular organizer of synaptic plasticity, learning and memory

Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific

(2022) Martin Hruska et al.   Nature Communications

CaMKII binds both substrates and activators at the active site

(2022) Can Özden et al.   Cell Reports

Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons

(2021) Xingzhi He et al.   NEURON

Photoactivatable CaMKII induces synaptic plasticity in single synapses

(2021) Akihiro C. E. Shibata et al.   Nature Communications

CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3

(2021) Jaehoon Jeong et al.   eNeuro

CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation

(2021) Tomohisa Hosokawa et al.   NATURE NEUROSCIENCE

CaMKII holoenzyme mechanisms that govern the LTP versus LTD decision

(2021) Sarah G. Cook et al.   Science Advances

Regulation of NMDA receptor trafficking and gating by activity-dependent CaMKIIα phosphorylation of the GluN2A subunit

(2021) Xuan Ling Hilary Yong et al.   Cell Reports

Synaptic memory requires CaMKII

(2021) Wucheng Tao et al.   eLife

GluN2B S1303 phosphorylation by CaMKII or DAPK1: No indication for involvement in ischemia or LTP

(2021) Jonathan E. Tullis et al.   iScience

Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction

(2020) Tyler L. Perfitt et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent redistribution of CaMKII in the postsynaptic compartment of hippocampal neurons

(2020) Jung-Hwa Tao-Cheng   Molecular Brain

Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly

(2020) Cosima Rhein et al.   BRAIN RESEARCH BULLETIN

Nanoscale co-organization and coactivation of AMPAR, NMDAR, and mGluR at excitatory synapses

(2020) Julia Goncalves et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Epilepsy-Associated GRIN2A Rare Variant Disrupts CaMKIIα Phosphorylation of GluN2A and NMDA Receptor Trafficking

(2020) Marta Mota Vieira et al.   Cell Reports

CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation

(2020) Qixu Cai et al.   CELL RESEARCH

Somatostatin-Expressing Interneurons Enable and Maintain Learning-Dependent Sequential Activation of Pyramidal Neurons

(2019) Avital Adler et al.   NEURON

CAMK2-dependent signaling in neurons is essential for survival

(2019) Martijn J. Kool et al.   JOURNAL OF NEUROSCIENCE

Reciprocal Activation within a Kinase-Effector Complex Underlying Persistence of Structural LTP

(2019) Takeo Saneyoshi et al.   NEURON

Simultaneous Live Imaging of Multiple Endogenous Proteins Reveals a Mechanism for Alzheimer’s-Related Plasticity Impairment

(2019) Sarah G. Cook et al.   Cell Reports

FRET-based sensor for CaMKII activity (FRESCA): A useful tool for assessing CaMKII activity in response to Ca2+ oscillations in live cells

(2019) Goli Ardestani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of Ca2+/calmodulin-dependent kinase II activation in single dendritic spines

(2019) Jui-Yun Chang et al.   Nature Communications

The role of CaMKII-Tiam1 complex on learning and memory

(2019) Hiroto Kojima et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic Transmission

(2019) Menglong Zeng et al.   NEURON

CaM Kinase: Still Inspiring at 40

(2019) K. Ulrich Bayer et al.   NEURON

Assemblies of calcium/calmodulin-dependent kinase II with actin and their dynamic regulation by calmodulin in dendritic spines

(2019) Qian Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State

(2019) Stephen C. Thornquist et al.   NEURON

A multi-state model of the CaMKII dodecamer suggests a role for calmodulin in maintenance of autophosphorylation

(2019) Matthew C. Pharris et al.   PLoS Computational Biology

The Neuronal Gene Arc Encodes a Repurposed Retrotransposon Gag Protein that Mediates Intercellular RNA Transfer

(2018) Elissa D. Pastuzyn et al.   CELL

Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

(2018) James Ashley et al.   CELL

Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains

(2018) Lei Zhang et al.   NEURON

α-Actinin Anchors PSD-95 at Postsynaptic Sites

(2018) Lucas Matt et al.   NEURON

LTP requires postsynaptic PDZ-domain interactions with glutamate receptor/auxiliary protein complexes

(2018) Nengyin Sheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Locally coordinated synaptic plasticity of visual cortex neurons in vivo

(2018) Sami El-Boustani et al.   SCIENCE

The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms

(2018) Salvatore Incontro et al.   Nature Communications

Analysis of the CaMKIIα and β splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation

(2018) Sarah G. Cook et al.   Scientific Reports

A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability

(2018) Poh Hui Chia et al.   eLife

De novo variants in CAMK2A and CAMK2B cause neurodevelopmental disorders

(2018) Tenpei Akita et al.   Annals of Clinical and Translational Neurology

Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling

(2018) Tommaso Patriarchi et al.   EMBO JOURNAL

The Ras-like GTPase Rem2 is a potent inhibitor of calcium/calmodulin-dependent kinase II activity

(2018) Leandro Royer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase

(2018) Artur F. Castro-Rodrigues et al.   JOURNAL OF MOLECULAR BIOLOGY

A novel mechanism for Ca2+/calmodulin-dependent protein kinase II targeting to L-type Ca2+channels that initiates long-range signaling to the nucleus

(2017) Xiaohan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth

(2017) A.M. Hamilton et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor

(2017) Hideji Murakoshi et al.   NEURON

CaMKII Autophosphorylation Is Necessary for Optimal Integration of Ca 2+ Signals during LTP Induction, but Not Maintenance

(2017) Jui-Yun Chang et al.   NEURON

Memory Erasure Experiments Indicate a Critical Role of CaMKII in Memory Storage

(2017) Tom Rossetti et al.   NEURON

Imaging ERK and PKA Activation in Single Dendritic Spines during Structural Plasticity

(2017) Shen Tang et al.   NEURON

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

The CaMKII holoenzyme structure in activation-competent conformations

(2017) Janette B. Myers et al.   Nature Communications

DAPK1 Mediates LTD by Making CaMKII/GluN2B Binding LTP Specific

(2017) Dayton J. Goodell et al.   Cell Reports

Phosphorylation of Ser1928mediates the enhanced activity of the L-type Ca2+channel Cav1.2 by the β2-adrenergic receptor in neurons

(2017) Hai Qian et al.   Science Signaling

High-Throughput, High-Resolution Mapping of Protein Localization in Mammalian Brain by In Vivo Genome Editing

(2016) Takayasu Mikuni et al.   CELL

Interplay of enzymatic and structural functions of CaMKII in long-term potentiation

(2016) Karam Kim et al.   JOURNAL OF NEUROCHEMISTRY

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

(2016) Nathan G. Hedrick et al.   NATURE

CaMKII Phosphorylation of TARPγ-8 Is a Mediator of LTP and Learning and Memory

(2016) Joongkyu Park et al.   NEURON

NMDA Receptor-Dependent LTD Requires Transient Synaptic Incorporation of Ca 2+ -Permeable AMPARs Mediated by AKAP150-Anchored PKA and Calcineurin

(2016) Jennifer L. Sanderson et al.   NEURON

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP

(2016) Bruce E. Herring et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extensive phosphorylation of AMPA receptors in neurons

(2016) Graham H. Diering et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impermanence of dendritic spines in live adult CA1 hippocampus

(2015) Alessio Attardo et al.   NATURE

A Temporary Gating of Actin Remodeling during Synaptic Plasticity Consists of the Interplay between the Kinase and Structural Functions of CaMKII

(2015) Karam Kim et al.   NEURON

Stoichiometry and Phosphoisotypes of Hippocampal AMPA-Type Glutamate Receptor Phosphorylation

(2015) Tomohisa Hosokawa et al.   NEURON

Lengthening of the Stargazin Cytoplasmic Tail Increases Synaptic Transmission by Promoting Interaction to Deeper Domains of PSD-95

(2015) Anne-Sophie Hafner et al.   NEURON

Differential Distribution of Shank and GKAP at the Postsynaptic Density

(2015) Jung-Hwa Tao-Cheng et al.   PLoS One

Liquid-Liquid Phase Separation in Biology

(2014) Anthony A. Hyman et al.   Annual Review of Cell and Developmental Biology

In Vitro Reconstitution of a CaMKII Memory Switch by an NMDA Receptor-Derived Peptide

(2014) Hidetoshi Urakubo et al.   BIOPHYSICAL JOURNAL

γCaMKII Shuttles Ca2+/CaM to the Nucleus to Trigger CREB Phosphorylation and Gene Expression

(2014) Huan Ma et al.   CELL

Autonomous CaMKII requires further stimulation by Ca2+/calmodulin for enhancing synaptic strength

(2014) Kelsey Barcomb et al.   FASEB JOURNAL

Multiple Spatial and Kinetic Subpopulations of CaMKII in Spines and Dendrites as Resolved by Single-Molecule Tracking PALM

(2014) H. E. Lu et al.   JOURNAL OF NEUROSCIENCE

Kinases and Pseudokinases: Lessons from RAF

(2014) A. S. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

CaMKII: Claiming Center Stage in Postsynaptic Function and Organization

(2014) Johannes W. Hell   NEURON

Structural and Molecular Remodeling of Dendritic Spine Substructures during Long-Term Potentiation

(2014) Miquel Bosch et al.   NEURON

Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection

(2014) Steven J. Coultrap et al.   Cell Reports

Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

(2014) Il Hwan Kim et al.   eLife

Calcium-Calmodulin-Dependent Protein Kinase II Isoforms Differentially Impact the Dynamics and Structure of the Actin Cytoskeleton

(2013) Laurel Hoffman et al.   BIOCHEMISTRY

Subcellular organization of camkii in rat hippocampal pyramidal neurons

(2013) Jin-Dong Ding et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Long-Distance Integration of Nuclear ERK Signaling Triggered by Activation of a Few Dendritic Spines

(2013) S. Zhai et al.   SCIENCE

Nonlinear Decoding and Asymmetric Representation of Neuronal Input Information by CaMKIIα and Calcineurin

(2013) Hajime Fujii et al.   Cell Reports

Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors

(2013) Antonio Sanz-Clemente et al.   Cell Reports

Inverse Synaptic Tagging of Inactive Synapses via Dynamic Interaction of Arc/Arg3.1 with CaMKIIβ

(2012) Hiroyuki Okuno et al.   CELL

The Ca2+ and Rho GTPase signaling pathways underlying activity-dependent actin remodeling at dendritic spines

(2012) Takeo Saneyoshi et al.   Cytoskeleton

CaMKII binding to GluN2B is critical during memory consolidation

(2012) Amy R Halt et al.   EMBO JOURNAL

Substrate-selective and Calcium-independent Activation of CaMKII by α-Actinin

(2012) Nidhi Jalan-Sakrikar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of CaMKII to dendritic microtubules supports the plasticity of local synapses

(2012) Mado Lemieux et al.   JOURNAL OF CELL BIOLOGY

Mechanisms of CaMKII action in long-term potentiation

(2012) John Lisman et al.   NATURE REVIEWS NEUROSCIENCE

Activity-Dependent Growth of New Dendritic Spines Is Regulated by the Proteasome

(2012) Andrew M. Hamilton et al.   NEURON

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

(2011) Luke H. Chao et al.   CELL

Ca2+induces clustering of membrane proteins in the plasma membrane via electrostatic interactions

(2011) Felipe E Zilly et al.   EMBO JOURNAL

Nucleotides and Phosphorylation Bi-directionally Modulate Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Binding to theN-Methyl-d-aspartate (NMDA) Receptor Subunit GluN2B

(2011) Heather O'Leary et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength

(2011) M. Sanhueza et al.   JOURNAL OF NEUROSCIENCE

 CaMKII Plays a Nonenzymatic Role in Hippocampal Synaptic Plasticity and Learning by Targeting  CaMKII to Synapses

(2011) N. Z. Borgesius et al.   JOURNAL OF NEUROSCIENCE

Trafficking of AMPA Receptors at Plasma Membranes of Hippocampal Neurons

(2011) J.-H. Tao-Cheng et al.   JOURNAL OF NEUROSCIENCE

Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice

(2011) Richard M. Gustin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Local, persistent activation of Rho GTPases during plasticity of single dendritic spines

(2011) Hideji Murakoshi et al.   NATURE

PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity

(2011) Akio Sumioka et al.   NATURE NEUROSCIENCE

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating

(2011) Anders S Kristensen et al.   NATURE NEUROSCIENCE

Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines

(2010) Baris Bingol et al.   CELL

CaMKII Autonomy Is Substrate-dependent and Further Stimulated by Ca2+/Calmodulin

(2010) Steven J. Coultrap et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CaMKII "Autonomy" Is Required for Initiating But Not for Maintaining Neuronal Long-Term Information Storage

(2010) I. Buard et al.   JOURNAL OF NEUROSCIENCE

Autonomous CaMKII Can Promote either Long-Term Potentiation or Long-Term Depression, Depending on the State of T305/T306 Phosphorylation

(2010) H. J. Pi et al.   JOURNAL OF NEUROSCIENCE

Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation

(2010) Luke H Chao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin

(2010) Patricio Opazo et al.   NEURON

TARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers

(2010) Akio Sumioka et al.   NEURON

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Synaptic targeting of AMPA receptors is regulated by a CaMKII site in the first intracellular loop of GluA1

(2010) W. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

  Ca2+/CaM-dependent kinase type II triggers upregulation of GluA1 to coordinate adaptation to synaptic inactivity in hippocampal neurons

(2010) R. D. Groth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII control of spine size and synaptic strength: Role of phosphorylation states and nonenzymatic action

(2010) H. J. Pi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus

(2009) Hey-Kyoung Lee et al.   JOURNAL OF NEUROPHYSIOLOGY

Kinase-Dead Knock-In Mouse Reveals an Essential Role of Kinase Activity of Ca2+/Calmodulin-Dependent Protein Kinase II  in Dendritic Spine Enlargement, Long-Term Potentiation, and Learning

(2009) Y. Yamagata et al.   JOURNAL OF NEUROSCIENCE

A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory

(2009) Ursula Haditsch et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Activation of CaMKII in single dendritic spines during long-term potentiation

(2009) Seok-Jin R. Lee et al.   NATURE

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

(2009) Kevin M Woolfrey et al.   NATURE NEUROSCIENCE

Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity

(2008) Pascal Steiner et al.   NEURON

Critical Role of CDK5 and Polo-like Kinase 2 in Homeostatic Synaptic Plasticity during Elevated Activity

(2008) Daniel P. Seeburg et al.   NEURON

Optical induction of plasticity at single synapses reveals input-specific accumulation of  CaMKII

(2008) Y.-P. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CaMKII  binding to stable F-actin in vivo regulates F-actin filament stability

(2008) Y.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine

(2008) C. D. Harvey et al.   SCIENCE