The Chemistry and Pharmacology of Citrus Limonoids

Identification of the chemical compositions of Ponkan peel by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

(2016) Ying Yang et al.   Analytical Methods

Recent Trends in the Discovery of Small Molecule Blockers of Sodium Channels

(2016) Roberta Gualdani et al.   CURRENT MEDICINAL CHEMISTRY

Antioxidant activity of Citrus fruits

(2016) Zhuo Zou et al.   FOOD CHEMISTRY

Spatio-temporal distribution and natural variation of metabolites in citrus fruits

(2016) Shouchuang Wang et al.   FOOD CHEMISTRY

Dietary supplementation with purified citrus limonin glucoside does not alter ex vivo functions of circulating T lymphocytes or monocytes in overweight/obese human adults

(2016) Susan J. Zunino et al.   NUTRITION RESEARCH

Bergamot ( Citrus bergamia Risso ) as a source of nutraceuticals: Limonoids and flavonoids

(2016) Marina Russo et al.   Journal of Functional Foods

Total Synthesis of Limonin

(2015) Shuji Yamashita et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dietary obacunone supplementation stimulates muscle hypertrophy, and suppresses hyperglycemia and obesity through the TGR5 and PPARγ pathway

(2015) Taro Horiba et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chemotaxonomic significance of limonoids and triterpenoids from Dictamnus angustifolius G. Don ex Sweet

(2015) Meng-ying Lv et al.   BIOCHEMICAL SYSTEMATICS AND ECOLOGY

Insight into reduction of obacunone, and their ester derivatives as insecticidal agents against Mythimna separata Walker

(2015) Xiang Yu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Non-targeted metabolite profiling of citrus juices as a tool for variety discrimination and metabolite flow analysis

(2015) Vicent Arbona et al.   BMC PLANT BIOLOGY

Chemical and biological comparison of the fruit extracts of Citrus wilsonii Tanaka and Citrus medica L.

(2015) Pan Zhao et al.   FOOD CHEMISTRY

Ethylene degreening modulates health promoting phytochemicals in Rio Red grapefruit

(2015) Priyanka R. Chaudhary et al.   FOOD CHEMISTRY

Suppression of intestinal carcinogenesis in Apc-mutant mice by limonin

(2015) Satomi Shimizu et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Medicinal uses, phytochemistry and pharmacology of the genus Dictamnus (Rutaceae)

(2015) Mengying Lv et al.   JOURNAL OF ETHNOPHARMACOLOGY

Characterization of lemon (Citrus limon) polar extract by liquid chromatography-tandem mass spectrometry in high resolution mode

(2015) C. A. Ledesma-Escobar et al.   JOURNAL OF MASS SPECTROMETRY

Development of delayed bitterness and effect of harvest date in stored juice from two complex citrus hybrids

(2015) Smita Raithore et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Triterpenoids

(2015) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Citrus limonoid nomilin inhibits osteoclastogenesis in vitro by suppression of NFATc1 and MAPK signaling pathways

(2015) Yoshifumi Kimira et al.   PHYTOMEDICINE

Comparative metabolism of four limonoids in human liver microsomes using ultra-high-performance liquid chromatography coupled with high-resolution LTQ-Orbitrap mass spectrometry

(2015) Wei Ren et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Cytotoxicity of obacunone and obacunone glucoside in human prostate cancer cells involves Akt-mediated programmed cell death

(2015) Kotamballi N. Chidambara Murthy et al.   TOXICOLOGY

A novel component from citrus, ginger, and mushroom family exhibits antitumor activity on human meningioma cells through suppressing the Wnt/β-catenin signaling pathway

(2015) Arabinda Das et al.   TUMOR BIOLOGY

An insight into the role of citrus bioactives in modulation of colon cancer

(2015) Jasleen Kaur et al.   Journal of Functional Foods

Citrus limonin glucoside supplementation decreased biomarkers of liver disease and inflammation in overweight human adults

(2015) Darshan S. Kelley et al.   Journal of Functional Foods

Synthesis and quantitative structure–activity relationship (QSAR) study of C7-oxime ester derivatives of obacunone as insecticidal agents

(2015) Xiang Yu et al.   RSC Advances

Limonoids from the root bark of Dictamnus angustifolius: potent neuroprotective agents with biometal chelation and halting copper redox cycling properties

(2015) Jian-Bo Sun et al.   RSC Advances

Plant metabolomics driven chemical and biological comparison of the root bark of Dictamnus dasycarpus and Dictamnus angustifolius

(2015) Mengying Lv et al.   RSC Advances

Obacunone exhibits anti-proliferative and anti-aromatase activity in vitro by inhibiting the p38 MAPK signaling pathway in MCF-7 human breast adenocarcinoma cells

(2014) Jinhee Kim et al.   BIOCHIMIE

Synthesis and pharmacological evaluation of novel limonin derivatives as anti-inflammatory and analgesic agents with high water solubility

(2014) Yun Yang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway

(2014) Mona F. Mahmoud et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Simultaneous Purification of Limonin, Nomilin and Isoobacunoic Acid from Pomelo Fruit (Citrus grandis) Segment Membrane

(2014) Yu Xiang et al.   JOURNAL OF FOOD SCIENCE

Features of citrus terpenoid production as revealed by carotenoid, limonoid and aroma profiles of two pummelos (Citrus maxima) with different flesh color

(2014) Cuihua Liu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

New depside fromCitrus reticulataBlanco

(2014) Uraiwan Phetkul et al.   NATURAL PRODUCT RESEARCH

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

A Novel Diterpene Skeleton: Identification of a Highly Aromatic, Cytotoxic and Antioxidant 5-Methyl-10-demethyl-abietane-type Diterpene fromPremna serratifolia

(2014) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Antiinflammatory Properties of the Stem-bark ofAnopyxis klaineanaand its Major Constituent, Methyl Angolensate

(2014) Evelyn A. Mireku et al.   PHYTOTHERAPY RESEARCH

Species-related difference between limonin and obacunone among five liver microsomes and zebrafish using ultra-high-performance liquid chromatography coupled with a LTQ-Orbitrap mass spectrometer

(2014) Wei Ren et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

(2013) Siwattra Choodej et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A convenient synthesis of lubeluzole and its enantiomer: Evaluation as chemosensitizing agents on human ovarian adenocarcinoma and lung carcinoma cells

(2013) Maria Maddalena Cavalluzzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters

(2013) Michael D. Shultz   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protective effect of compounds from the flowers of Citrus aurantium L. var. amara Engl against carbon tetrachloride-induced hepatocyte injury

(2013) Qun Lu et al.   FOOD AND CHEMICAL TOXICOLOGY

Content changes of bitter compounds in ‘Guoqing No.1’ Satsuma mandarin (Citrus unshiu Marc.) during fruit development of consecutive 3 seasons

(2013) Shaojie Li et al.   FOOD CHEMISTRY

Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: applicatio

(2013) Huarong Xu et al.   JOURNAL OF MASS SPECTROMETRY

Effect of extraction, pasteurization and cold storage on flavonoids and other secondary metabolites in fresh orange juice

(2013) Jinhe Bai et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Non-targeted metabolomic analysis of orange (Citrus sinensis [L.] Osbeck) wild type and bud mutant fruits by direct analysis in real-time and HPLC-electrospray mass spectrometry

(2013) Zhiyong Pan et al.   Metabolomics

Triterpenoids

(2013) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

New acridone from the wood ofCitrus reticulataBlanco

(2013) Uraiwan Phetkul et al.   NATURAL PRODUCT RESEARCH

Hepatoprotective effect of limonin, a natural limonoid from the seed of Citrus aurantium var. bigaradia, on D-galactosamine-induced liver injury in rats

(2013) Mona F. Mahmoud et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Benzene, coumarin and quinolinone derivatives from roots of Citrus hystrix

(2013) Kanda Panthong et al.   PHYTOCHEMISTRY

Citrus limonoids and curcumin additively inhibit human colon cancer cells

(2013) Kotamballi N. Chidambara Murthy et al.   Food & Function

The functional evaluation of waste yuzu (Citrus junos) seeds

(2013) Mayumi Minamisawa et al.   Food & Function

Obacunone Represses Salmonella Pathogenicity Islands 1 and 2 in anenvZ-Dependent Fashion

(2012) Amit Vikram et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Isolimonic acid interferes with Escherichia coli O157:H7 biofilm and TTSS in QseBC and QseA dependent fashion

(2012) Amit Vikram et al.   BMC MICROBIOLOGY

An Overview on Chemical Aspects and Potential Health Benefits of Limonoids and Their Derivatives

(2012) Rosa Tundis et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Bioactivity evaluations of ingredients extracted from the flowers of Citrus aurantium L. var. amara Engl

(2012) Hai-Yan Zhao et al.   FOOD CHEMISTRY

Degreening and postharvest storage influences ‘Star Ruby’ grapefruit (Citrus paradisi Macf.) bioactive compounds

(2012) Priyanka Chaudhary et al.   FOOD CHEMISTRY

Limonin 7-methoxime interferes with Escherichia coli biofilm formation and attachment in type 1 pili and antigen 43 dependent manner

(2012) Amit Vikram et al.   FOOD CONTROL

Simultaneous quantification of coumarins, flavonoids and limonoids in Fructus Citri Sarcodactylis by high performance liquid chromatography coupled with diode array detector

(2012) Jun Chu et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Triterpenoids

(2012) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Antioxidant and Anti-α-glucosidase Compounds from the Rhizome ofPeltiphyllum peltatum(Torr.) Engl

(2012) Solomon Habtemariam et al.   PHYTOTHERAPY RESEARCH

Methyl nomilinate from citrus can modulate cell cycle regulators to induce cytotoxicity in human colon cancer (SW480) cells in vitro

(2012) Jinhee Kim et al.   TOXICOLOGY IN VITRO

Secondary Metabolites of Ponderosa Lemon (Citrus pyriformis) and their Antioxidant, Anti-Infl ammatory, and Cytotoxic Activities

(2012) D. Hamdan et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES

Limonoids and their anti-proliferative and anti-aromatase properties in human breast cancer cells

(2012) Jinhee Kim et al.   Food & Function

Anti-obesity and anti-hyperglycemic effects of the dietary citrus limonoid nomilin in mice fed a high-fat diet

(2011) Eri Ono et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Antiviral activity of seed extract from Citrus bergamia towards human retroviruses

(2011) Emanuela Balestrieri et al.   BIOORGANIC & MEDICINAL CHEMISTRY

seco-Limonoids and Quinoline Alkaloids from Raputia heptaphylla and Their Antileishmanial Activity

(2011) Carlos Andres Coy Barrera et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The Advances in the Limonoid Chemistry of the Meliaceae Family

(2011) Fang X. et al.   CURRENT ORGANIC CHEMISTRY

Structure–function relationships of citrus limonoids on p38 MAP kinase activity in human aortic smooth muscle cells

(2011) Jinhee Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of chemopreventive and cytotoxic effect of lemon seed extracts on human breast cancer (MCF-7) cells

(2011) Jinhee Kim et al.   FOOD AND CHEMICAL TOXICOLOGY

Chemical composition and biological activity of Citrus jambhiri Lush

(2011) Dalia Hamdan et al.   FOOD CHEMISTRY

Methyl-3-O-Methyl Gallate and Gallic Acid from the Leaves of Peltiphyllum peltatum: Isolation and Comparative Antioxidant, Prooxidant, and Cytotoxic Effects in Neuronal Cells

(2011) Solomon Habtemariam   JOURNAL OF MEDICINAL FOOD

Limonoid content of sour orange varieties

(2011) Andrew P Breksa et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Liquid chromatography–mass spectrometry-based metabolomics for authenticity assessment of fruit juices

(2011) Lukas Vaclavik et al.   Metabolomics

Triterpenoids

(2011) Robert A. Hill et al.   NATURAL PRODUCT REPORTS

Mosquito larvicidal activity of citrus limonoids against Aedes albopictus

(2011) Faisal Hafeez et al.   PARASITOLOGY RESEARCH

Phytochemical, Antioxidant and Anti-α-glucosidase Activity Evaluations of Bergenia cordifolia

(2011) Mariagrazia Roselli et al.   PHYTOTHERAPY RESEARCH

Inhibitory effects of limonin on six human cytochrome P450 enzymes and P-glycoprotein in vitro

(2011) Yong-Long Han et al.   TOXICOLOGY IN VITRO

Molecular obesity, potency and other addictions in drug discovery

(2011) Michael M. Hann   MedChemComm

In vivo induction of phase II detoxifying enzymes, glutathione transferase and quinone reductase by citrus triterpenoids

(2010) Jose L Perez et al.   BMC Complementary and Alternative Medicine

Anti-inflammatory Principles from the Stem and Root Barks of Citrus medica

(2010) Yu-Yi Chan et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

(2010) Tao Feng et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The impact of aromatic ring count on compound developability: further insights by examining carbo- and hetero-aromatic and -aliphatic ring types

(2010) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Synthesis of Limonoid Natural Products

(2010) Brian Heasley   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Antioxidant compounds from a South Asian beverage and medicinal plant, Cassia auriculata

(2010) Malindra Juan-Badaturuge et al.   FOOD CHEMISTRY

Grapefruit bioactive limonoids modulate E. coli O157:H7 TTSS and biofilm

(2010) Amit Vikram et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Identification and characterization of cellular locus of limonin biotransforming enzyme inPseudomonas putida

(2010) Jay Prakash Verma et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY

Simultaneous separation and identification of limonoids from citrus using liquid chromatography-collision-induced dissociation mass spectra

(2010) Guddadarangavvanahally K. Jayaprakasha et al.   JOURNAL OF SEPARATION SCIENCE

Citrus limonoids interfere with Vibrio harveyi cell-cell signalling and biofilm formation by modulating the response regulator LuxO

(2010) A. Vikram et al.   MICROBIOLOGY-SGM

Limonoids and Quinoline Alkaloids fromDictamnus dasycarpus

(2010) Jun-Li Yang et al.   PLANTA MEDICA

Isolation of Acridone Alkaloids and N-[(4-Monoterpenyloxy)phenylethyl]-Substituted Sulfur-Containing Propanamide Derivatives from Glycosmis parva and Their Anti-herpes Simplex Virus Activity

(2009) Chaisak Chansriniyom et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?

(2009) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Inhibition of P-glycoprotein activity by limonin and other secondary metabolites from Citrus species in human colon and leukaemia cell lines

(2009) Mahmoud Zaki El-Readi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Liquid chromatography–electrospray ionisation mass spectrometry method for the rapid identification of citrus limonoid glucosides in citrus juices and extracts

(2009) Andrew P. Breksa III et al.   FOOD CHEMISTRY

Chemical Constituents and Cytotoxicity from the Stem Bark of Citrus medica

(2009) Tian-Shung Wu et al.   HETEROCYCLES

Limonin Methoxylation Influences the Induction of GlutathioneS-Transferase and Quinone Reductase

(2009) Jose Luis Perez et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioactive Compounds from Mexican Lime (Citrus aurantifolia) Juice Induce Apoptosis in Human Pancreatic Cells

(2009) Jaiprakash R. Patil et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioactive Compounds: Historical Perspectives, Opportunities, and Challenges

(2009) Bhimanagouda S. Patil et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Bioactive Compounds from Sour Orange Inhibit Colon Cancer Cell Proliferation and Induce Cell Cycle Arrest

(2009) G. K. Jayaprakasha et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effect of Liberibacter Infection (Huanglongbing Disease) of Citrus on Orange Fruit Physiology and Fruit/Fruit Juice Quality: Chemical and Physical Analyses

(2009) Elizabeth Baldwin et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of Citrus aurantifolia bioactive compounds and their inhibition of human pancreatic cancer cells through apoptosis

(2009) Jaiprakash R. Patil et al.   MICROCHEMICAL JOURNAL

Triterpenoids

(2009) Joseph D. Connolly et al.   NATURAL PRODUCT REPORTS

Exploring the third dimension

(2009) Katie Kingwell   NATURE REVIEWS DRUG DISCOVERY

Differential cytotoxic and prooxidnant activity of knipholone and knipholone anthrone

(2009) S Habtemariam et al.   PLANTA MEDICA

Comparative Antioxidant, Prooxidant and Cytotoxic Activity of Sigmoidin A and Eriodictyol

(2009) Solomon Habtemariam et al.   PLANTA MEDICA

Novel triterpenoid from Citrus aurantium L. possesses chemopreventive properties against human colon cancer cells

(2008) G.K. Jayaprakasha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

On the non-enzymatic liberation of limonin and C17-epilimonin from limonin-17-β-d-glucopyranoside in orange juice

(2008) Anneke Glabasnia et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Development and validation of a decigram-scale method for the separation of limonin from limonin glucoside by C-18 flash chromatography

(2008) Andrew P. Breksa et al.   FOOD CHEMISTRY

Chemical Characterization ofCitrus sinensisGrafted onC. limoniaand the Effect of Some Isolated Compounds on the Growth ofXylella fastidiosa

(2008) Alan Bezerra Ribeiro et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Isolation and Identification of the First C-17 Limonin Epimer, Epilimonin

(2008) Andrew P. Breksa et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective Limonoids of Root Bark ofDictamnus dasycarpus

(2008) Jeong Seon Yoon et al.   JOURNAL OF NATURAL PRODUCTS

Simple Enantioselective Approach to Synthetic Limonoids

(2008) Douglas C. Behenna et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stability of limonin glucoside in beverage matrices

(2008) Andrew P Breksa III et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Triterpenoids

(2008) Joseph D. Connolly et al.   NATURAL PRODUCT REPORTS

An overview of the genus Xylocarpus

(2008) Vijai Lakshmi et al.   NATURAL PRODUCT RESEARCH