Article
Plant Sciences
Aonnicha Sombatsri, Thurdpong Sribuhom, Suphanthip Phusrisom, Veerapol Kukongviriyapan, Chavi Yenjai
Summary: Two new compounds, a rearranged limonoid (harriforanoid) and a benzopyran (harriforanone), were isolated from the leaves and stems of Harrisonia perforata, along with three known limonoids and fourteen known chromones. The structures of the compounds were determined using spectroscopic analysis, and the absolute configuration of harriforanone was characterized using experimental and calculated ECD spectra. However, none of the compounds showed cytotoxic activity against cholangiocarcinoma and human liver cancer cell lines.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Min Cai, Xiao-Lin Bai, Hao-Jing Zang, Xiao-Han Tang, Ying Yan, Jia-Jia Wan, Min-You Peng, Hong Liang, Lin Liu, Feng Guo, Pei-Ji Zhao, Xun Liao, Ying-Tong Di, Xiao-Jiang Hao
Summary: In this study, six new C-20 and one new C-19 quassinoids were isolated and identified from the twigs of Harrisonia perforata. Two of these compounds showed significant anti-Parkinson's disease potential in both cell and Drosophila models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Sarot Cheenpracha, Ratchanaporn Chokchaisiri, Lucksagoon Ganranoo, Tharakorn Maneerat, Narawadee Rujanapun, Rawiwan Charoensup, Surat Laphookhieo, Natcha Injan, Somkiat Nokbin
Summary: In this study, three new isoprenylated chromones were isolated from the stems of Harrisonia perforata, and two of them showed anti-inflammatory effects.
PHYTOCHEMISTRY LETTERS
(2022)
Article
Chemistry, Organic
Shen Zhangyang, Li Yujie, Zhao Yimeng, Deng Yayuan, Guo Yawen, Wang Yu, Liu Yanping, Fu Yanhui
Summary: A new prenylated isoflavone, harriperforine (1), and seven known analogues were isolated and characterized from the stems of Harrisonia perforata. Their chemical structures were determined by spectroscopic analysis. Compounds 1 to 8 displayed remarkable inhibitory activities against five cancer cell lines, with IC50 values comparable to cisplatin.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Erina Hilmayanti, Nurlelasari, Unang Supratman, Kazuya Kabayama, Atsushi Shimoyama, Koichi Fukase
Summary: Limonoids, compounds found mainly in certain plant families, have been shown to have a wide range of biological activities including anti-inflammatory, antioxidant, and anticancer effects. However, there is still limited research on the anti-inflammatory effects of limonoids isolated from plants.
Article
Chemistry, Organic
Xiao-Han Tang, Rong-Can Luo, Mao-Sen Ye, Hong-Yu Tang, Yuan-Liang Ma, Yan-Ni Chen, Xin-Meng Wang, Qing-Yun Lu, Shuai Liu, Xiao-Nian Li, Ying Yan, Jing Yang, Xiao-Qian Ran, Xin Fang, Yan Zhou, Yong-Gang Yao, Ying-Tong Di, Xiao-Jiang Hao
Summary: Harpertrioate A, isolated from the twigs of Harrisonia perforata, showed biological activities against Alzheimer's disease by reducing the production of Aβ42 and Aβ40 and shifting the APP processing towards a nonamyloidogenic pathway. Its effect on Aβ production was comparable to that of gemfibrozil.
Article
Biochemistry & Molecular Biology
Isoo Youn, Kyu-Yeon Han, Aleksandra Gurgul, Zhenlong Wu, Hyun Lee, Chun-Tao Che
Summary: Six undescribed compounds were isolated from the stem bark of Entandrophragma angolense, and their structures were determined. Some of these compounds showed anti-inflammatory effects in in vitro experiments.
Article
Chemistry, Medicinal
Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Ming-Jen Cheng, Ming-Der Wu, Shu-Ling Fu, Jih-Jung Chen
Summary: New and rare chromone derivatives isolated from marine-derived Penicillium citrinum showed significant inhibition of superoxide anion generation in human neutrophils. Compounds 3 and 4 exhibited cytotoxic activities against non-small lung cancer cells and induced apoptosis through Bcl-2, Bax, and caspase 3 signaling cascades.
Article
Biochemistry & Molecular Biology
Yan Sun, Peng Jiang, Yi-Kai Jiang, Juan Pan, Jia-Tong Wu, Xiao-Mao Li, Wei Guan, Xin-Yu Min, Yu-Xuan Wang, Hai-Xue Kuang, Yan Liu, Bing-You Yang
Summary: Fifteen new chromones and fifteen known chromones were isolated from the roots of Saposhnikovia divaricata. Their structures were determined using NMR data and ECD calculations. The anti-inflammatory activity of these compounds was evaluated using an in vitro inflammatory cell model, and compounds 2, 8, 12-13, 18, 20-22, 24, and 27 showed significant inhibition of LPS-induced NO production. Mechanistic studies revealed that compounds 12 and 13 inhibited the phosphorylation of ERK and the activation of ERK and JNK signaling in RAW264.7 cells via MAPK signaling pathways. These findings suggest that compounds 12 and 13 may be potential candidates for the treatment of inflammatory diseases.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yi-Cheng Chu, Chun-Hao Chang, Hsiang-Ruei Liao, Shu-Ling Fu, Jih-Jung Chen
Summary: In this study, three new and uncommon chromone analogs were isolated from marine-origin Penicillium citrinum, among which compounds 2-3 exhibited remarkable suppression of superoxide anion generation by human neutrophils and cytotoxic activities against human cancer cells. Compound 3 was found to induce apoptosis of HT-29 cells via Bcl-2, Bax, and caspase 3 signaling cascades.
Article
Biochemistry & Molecular Biology
Mustapha Ait El Had, Houda Zentar, Blanca Ruiz-Munoz, Juan Sainz, Juan J. Guardia, Antonio Fernandez, Jose Justicia, Enrique Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Rachid Chahboun
Summary: The synthesis of rearranged abietane diterpenes and evaluation of their anticancer and anti-inflammatory activities have been successfully achieved. In vitro studies showed that compounds 5 and 13 exhibited the highest cytotoxicity against HT29 colon cancer cells, with potential apoptosis induction. Furthermore, compound 5 demonstrated the highest anti-inflammatory potential by inhibiting nitric oxide production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Shuai Liu, Cui-Shan Zhang, Xiao-Qian Ran, Xiao-Han Tang, Ya-Rong Guo, Ying Yan, Yong-Gang Yao, Xiao-Jiang Hao, Rong-Can Luo, Ying-Tong Di
Summary: Two new quassinoids (1 and 2) isolated from the twigs of Harrisonia perforata possess unique structures and can induce lysosomal biogenesis through transcriptional activation of lysosomal genes.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Yucheng Zhang, Jiahao Liu, Qian Yao, Hong Deng, Caimei Yao, Tairan Kang, Xiaoqiang Guo
Summary: In this study, a series of eucryphin analogs were synthesized and compared with eucryphin and its 7-O-glycosyl derivatives for their anti-inflammatory activity, revealing the importance of glycosyl substitution at the C-3 position and the negative effect of methyl substitution at C-2 and glycosylation at C-7 on the anti-inflammatory activity of eucryphin.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Yali Zhang, Zhengwei Xu, Lingling Zhan, Yi Gao, Bin Zheng, Yan Zhou, Yaoguang Sheng, Guang Liang, Zengqiang Song
Summary: This study synthesized a series of new chromone-maleimide hybrids and tested their anti-inflammatory activity. Majority of the hybrids showed high inhibitory potency against pro-inflammatory cytokines released by macrophages, with five of them exhibiting strong inhibition. In addition, the in vivo administration of two hybrids resulted in significantly attenuated LPS-induced ALI. Therefore, these novel hybrids have promising therapeutic potential for ALI.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chenxu Zhao, Ha Gao, Jingrong Li, Meng Yu, Jiangping Wu, Haixin Zhang, Tao Zhang, Zhongmei Zou
Summary: This study identified several previously undescribed compounds from the extract of Gerbera piloselloides, including some that showed inhibitory effects on nitric oxide production and cancer cell proliferation.
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)