Development and Applications of the Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC) as a Bioorthogonal Reaction

All-in-One azides: empowered click reaction for in vivo labeling and imaging of biomolecules

(2016) Yaning Su et al.   CHEMICAL COMMUNICATIONS

Chemical proteomics approaches for identifying the cellular targets of natural products

(2016) M. H. Wright et al.   NATURAL PRODUCT REPORTS

A DFT Study on the Binuclear CuAAC Reaction: Mechanism in Light of New Experiments

(2016) Yılmaz Özkılıç et al.   ORGANOMETALLICS

A genetically encoded multifunctional unnatural amino acid for versatile protein manipulations in living cells

(2016) Yun Ge et al.   Chemical Science

Bioconjugation of therapeutic proteins and enzymes using the expanded set of genetically encoded amino acids

(2015) Sung In Lim et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Subunit-directed click coupling via doubly cross-linked hemoglobin efficiently produces readily purified functional bis-tetrameric oxygen carriers

(2015) Serena Singh et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

(2015) Estela Haldón et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Bioorthogonal Reactions for Labeling Proteins

(2014) Kathrin Lang et al.   ACS Chemical Biology

Finding the Right (Bioorthogonal) Chemistry

(2014) David M. Patterson et al.   ACS Chemical Biology

Copper-Chelating Azides for Efficient Click Conjugation Reactions in Complex Media

(2014) Valentina Bevilacqua et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Developments in the Field of Bioorthogonal Bond Forming Reactions—Past and Present Trends

(2014) Mathias King et al.   BIOCONJUGATE CHEMISTRY

Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry

(2014) Hao Jiang et al.   BIOCONJUGATE CHEMISTRY

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Transition metal-mediated bioorthogonal protein chemistry in living cells

(2014) Maiyun Yang et al.   CHEMICAL SOCIETY REVIEWS

Redox-based probes as tools to monitor oxidized protein tyrosine phosphatases in living cells

(2014) Francisco J. Garcia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Glycan Imaging in Intact Rat Hearts and Glycoproteomic Analysis Reveal the Upregulation of Sialylation during Cardiac Hypertrophy

(2014) Jie Rong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Bifunctional Unnatural Sialic Acids for Dual Metabolic Labeling of Cell-Surface Sialylated Glycans

(2013) Lianshun Feng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cis-Membrane FRET-Based Method for Protein-Specific Imaging of Cell-Surface Glycans

(2013) Wei Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Bioorthogonal labelling of biomolecules: new functional handles and ligation methods

(2013) Marjoke F. Debets et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions

(2013) B. T. Worrell et al.   SCIENCE

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Strain-Promoted Azide–Alkyne Cycloadditions of Benzocyclononynes

(2012) Jumreang Tummatorn et al.   JOURNAL OF ORGANIC CHEMISTRY

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioorthogonal Chemistry for Site-Specific Labeling and Surface Immobilization of Proteins

(2011) Yong-Xiang Chen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Tracking N-Acetyllactosamine on Cell-Surface Glycans In Vivo

(2011) Tianqing Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Increasing the Efficacy of Bioorthogonal Click Reactions for Bioconjugation: A Comparative Study

(2011) Christen Besanceney-Webler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A readily synthesized cyclic pyrrolysine analogue for site-specific protein “click” labeling

(2011) Ziyang Hao et al.   CHEMICAL COMMUNICATIONS

Posttranscriptional chemical functionalization of azide-modified oligoribonucleotides by bioorthogonal click and Staudinger reactions

(2011) Harita Rao et al.   CHEMICAL COMMUNICATIONS

A Non-Fluorinated Monobenzocyclooctyne for Rapid Copper-Free Click Reactions

(2011) Balázs R. Varga et al.   CHEMISTRY-A EUROPEAN JOURNAL

Click to Join Peptides/Proteins Together

(2011) Xuechen Li   Chemistry-An Asian Journal

Sulfated Ligands for the Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2011) Wei Wang et al.   Chemistry-An Asian Journal

Cellular Consequences of Copper Complexes Used To Catalyze Bioorthogonal Click Reactions

(2011) David C. Kennedy et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental Investigation on the Mechanism of Chelation-Assisted, Copper(II) Acetate-Accelerated Azide–Alkyne Cycloaddition

(2011) Gui-Chao Kuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein Glycoengineering Enabled by the Versatile Synthesis of Aminooxy Glycans and the Genetically Encoded Aldehyde Tag

(2011) Jason E. Hudak et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Incorporation of Photo-Cross-Linker and Bioorthogonal Amino Acids into Enteric Bacterial Pathogens

(2011) Shixian Lin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides

(2011) A. B. Neef et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Covalently immobilized tris(triazolyl)methanol–Cu(i) complexes: highly active and recyclable catalysts for CuAAC reactions

(2011) Erhan Ozkal et al.   Catalysis Science & Technology

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells

(2010) Jan Dommerholt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Thiol-Ene Click Chemistry

(2010) Charles E. Hoyle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Incorporation ofp-Propargyloxyphenylalanine in a Cell-Free Environment for Direct Protein−Protein Click Conjugation

(2010) Bradley C. Bundy et al.   BIOCONJUGATE CHEMISTRY

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Surface Functionalization Using Catalyst-Free Azide−Alkyne Cycloaddition

(2010) Alexander Kuzmin et al.   BIOCONJUGATE CHEMISTRY

Chelation-Assisted, Copper(II)-Acetate-Accelerated Azide−Alkyne Cycloaddition

(2010) Gui-Chao Kuang et al.   JOURNAL OF ORGANIC CHEMISTRY

Rapid Visualization and Large-Scale Profiling of Bacterial Lipoproteins with Chemical Reporters

(2010) Kavita J. Rangan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tailored Ligand Acceleration of the Cu-Catalyzed Azide−Alkyne Cycloaddition Reaction: Practical and Mechanistic Implications

(2010) Stanislav I. Presolski et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biocompatible Copper(I) Catalysts for in Vivo Imaging of Glycans

(2010) David Soriano del Amo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Cu-Free Click Chemistry with Readily Synthesized Biarylazacyclooctynones

(2010) John C. Jewett et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars

(2009) Pamela V. Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Analysis and Optimization of Copper-Catalyzed Azide–Alkyne Cycloaddition for Bioconjugation

(2009) Vu Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality

(2009) Ellen M. Sletten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hemoglobin bis-tetramers via cooperative azide–alkyne coupling

(2009) Jonathan S. Foot et al.   CHEMICAL COMMUNICATIONS

Phosphoramidite accelerated copper(i)-catalyzed [3 + 2] cycloadditions of azides and alkynes

(2009) Lachlan S. Campbell-Verduyn et al.   CHEMICAL COMMUNICATIONS

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition

(2009) Marjoke F. Debets et al.   CHEMICAL COMMUNICATIONS

Risks of Copper and Iron Toxicity during Aging in Humans

(2009) George J. Brewer   CHEMICAL RESEARCH IN TOXICOLOGY

Highly active copper-catalysts for azide-alkynecycloaddition

(2009) Zsombor Gonda et al.   DALTON TRANSACTIONS

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Robust Fluorescent Detection of Protein Fatty-Acylation with Chemical Reporters

(2009) Guillaume Charron et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of N-Terminally Linked Protein Dimers and Trimers by a Combined Native Chemical Ligation-CuAAC Click Chemistry Strategy

(2009) Junpeng Xiao et al.   ORGANIC LETTERS

Apparent Copper(II)-Accelerated Azide−Alkyne Cycloaddition

(2009) Wendy S. Brotherton et al.   ORGANIC LETTERS

A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol−Cu(I) Structure

(2009) Salih Özçubukçu et al.   ORGANIC LETTERS

Metabolic labeling and direct imaging of choline phospholipids in vivo

(2009) C. Y. Jao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing Metabolically Labeled Glycoconjugates of Living Cells by Copper-Free and Fast Huisgen Cycloadditions

(2008) Xinghai Ning et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

‘Click’ cycloaddition catalysts: copper(i) and copper(ii) tris(triazolylmethyl)amine complexes

(2008) Paul S. Donnelly et al.   CHEMICAL COMMUNICATIONS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode Nɛ-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification

(2008) Tatsuo Yanagisawa et al.   CHEMISTRY & BIOLOGY

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry

(2008) Julian A. Codelli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrazine Ligation: Fast Bioconjugation Based on Inverse-Electron-Demand Diels−Alder Reactivity

(2008) Melissa L. Blackman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence

(2008) Isabell Staub et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

(2008) Ellen M. Sletten et al.   ORGANIC LETTERS

A chemical method for fast and sensitive detection of DNA synthesis in vivo

(2008) A. Salic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA