Saharan dust induces NLRP3-dependent inflammatory cytokines in an alveolar air-liquid interface co-culture model

Inhalable Saharan dust induces oxidative stress, NLRP3 inflammasome activation, and inflammatory cytokine release

(2023) Gerrit Bredeck et al.   ENVIRONMENT INTERNATIONAL

Comparing α-Quartz-Induced Cytotoxicity and Interleukin-8 Release in Pulmonary Mono- and Co-Cultures Exposed under Submerged and Air-Liquid Interface Conditions

(2022) Alexandra Friesen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Investigating the Role of the NLRP3 Inflammasome Pathway in Acute Intestinal Inflammation: Use of THP-1 Knockout Cell Lines in an Advanced Triple Culture Model

(2022) Mathias Busch et al.   Frontiers in Immunology

The Microbiome of Size-Fractionated Airborne Particles from the Sahara Region

(2021) Rebecca A. Stern et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

(2021) Angela A. M. Kämpfer et al.   Small

Respiratory and Systemic Toxicity of Inhaled Artificial Asian Sand Dust in Pigs

(2021) Keon Kim et al.   Life-Basel

Fast but not furious: a streamlined selection method for genome-edited cells

(2021) Haribaskar Ramachandran et al.   Life Science Alliance

Pro-inflammatory effects of crystalline- and nano-sized non-crystalline silica particles in a 3D alveolar model

(2020) Tonje Skuland et al.   Particle and Fibre Toxicology

Single Intratracheal Quartz Instillation Induced Chronic Inflammation and Tumourigenesis in Rat Lungs

(2020) Yuko Nakano-Narusawa et al.   Scientific Reports

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

(2020) Hedwig M. Braakhuis et al.   Jove-Journal of Visualized Experiments

An In Vitro Lung System to Assess the Proinflammatory Hazard of Carbon Nanotube Aerosols

(2020) Hana Barosova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecularly Distinct NLRP3 Inducers Mediate Diverse Ratios of Interleukin-1β and Interleukin-18 from Human Monocytes

(2020) Kristine Midtbö et al.   MEDIATORS OF INFLAMMATION

Investigations of acute effects of polystyrene and polyvinyl chloride micro- and nanoplastics in an advanced in vitro triple culture model of the healthy and inflamed intestine

(2020) Mathias Busch et al.   ENVIRONMENTAL RESEARCH

The role of miR-431-5p in regulating pulmonary surfactant expression in vitro

(2019) Shujun Li et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

The health impact of Saharan dust exposure

(2019) Michail Kotsyfakis et al.   International Journal of Occupational Medicine and Environmental Health

Air-liquid interface culture changes surface properties of A549 cells

(2019) Kristin Öhlinger et al.   TOXICOLOGY IN VITRO

Desert dust outbreaks and respiratory morbidity in Athens, Greece

(2017) Stavroula-Myrto Trianti et al.   Environmental Health

Asian dust effect on cause-specific mortality in five cities across South Korea and Japan

(2016) Saori Kashima et al.   ATMOSPHERIC ENVIRONMENT

Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome

(2016) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

(2016) Thomas Loret et al.   Particle and Fibre Toxicology

Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure

(2016) Forrest Jessop et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

Desert Dust Outbreaks in Southern Europe: Contribution to Daily PM10 Concentrations and Short-Term Associations with Mortality and Hospital Admissions

(2015) Massimo Stafoggia et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Organic extracts from African dust storms stimulate oxidative stress and induce inflammatory responses in human lung cells through Nrf2 but not NF-κB

(2015) Rosa I. Rodríguez-Cotto et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Linking Endotoxins, African Dust PM10and Asthma in an Urban and Rural Environment of Puerto Rico

(2015) Mario G. Ortiz-Martínez et al.   MEDIATORS OF INFLAMMATION

Seasonal patterns of Saharan dust over Cape Verde – a combined approach using observations and modelling

(2015) Carla Gama et al.   TELLUS SERIES B-CHEMICAL AND PHYSICAL METEOROLOGY

Biological effects of desert dust in respiratory epithelial cells and a murine model

(2014) Andrew J. Ghio et al.   INHALATION TOXICOLOGY

Critical Role for the NLRP3 Inflammasome during Acute Lung Injury

(2014) J. J. Grailer et al.   JOURNAL OF IMMUNOLOGY

Why does the hemolytic activity of silica predict its pro-inflammatory activity?

(2014) Cristina Pavan et al.   Particle and Fibre Toxicology

An in vitro testing strategy towards mimicking the inhalation of high aspect ratio nanoparticles

(2014) Carola Endes et al.   Particle and Fibre Toxicology

Inhalable desert dust, urban emissions, and potentially biotoxic metals in urban Saharan–Sahelian air

(2014) V.H. Garrison et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Silica nanoparticles are less toxic to human lung cells when deposited at the air–liquid interface compared to conventional submerged exposure

(2014) Alicja Panas et al.   Beilstein Journal of Nanotechnology

Assessment of geographical variation in the respiratory toxicity of desert dust particles

(2013) Karen Taylor et al.   INHALATION TOXICOLOGY

The effect of Asian sand dust-activated respiratory epithelial cells on activation and migration of eosinophils

(2013) Seung-Heon Shin et al.   INHALATION TOXICOLOGY

Caspase-1: The inflammasome and beyond

(2013) Gabriel Sollberger et al.   Innate Immunity

Tek Hörgüçlü Develerde (Camelus dromedarius) Anrako-silikozisin Akciğerlerdeki Patolojik Bulguları ve Pömoni Oluşumundaki Rolü

(2013) Mehdi GOODARZI et al.   Kafkas Universitesi Veteriner Fakultesi Dergisi

Physico-chemical characterization of African urban aerosols (Bamako in Mali and Dakar in Senegal) and their toxic effects in human bronchial epithelial cells: description of a worrying situation

(2013) Stéphanie Val et al.   Particle and Fibre Toxicology

Effects of two Asian sand dusts transported from the dust source regions of Inner Mongolia and northeast China on murine lung eosinophilia

(2013) Miao He et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

(2012) Süheda Erener et al.   MOLECULAR CELL

Global-scale attribution of anthropogenic and natural dust sources and their emission rates based on MODIS Deep Blue aerosol products

(2012) Paul Ginoux et al.   REVIEWS OF GEOPHYSICS

Interleukin-18, interleukin-8, and CXCR2 and the risk of silicosis

(2012) Iraj Mohebbi et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Extreme air pollution events from bushfires and dust storms and their association with mortality in Sydney, Australia 1994–2007

(2011) Fay Johnston et al.   ENVIRONMENTAL RESEARCH

The Acute and Long-Term Effects of Middle East Sand Particles on the Rat Airway Following a Single Intratracheal Instillation

(2011) E. R. Wilfong et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Surface Iron Inhibits Quartz-Induced Cytotoxic and Inflammatory Responses in Alveolar Macrophages

(2010) Mara Ghiazza et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Airborne Asian sand dust enhances murine lung eosinophilia

(2010) Miao He et al.   INHALATION TOXICOLOGY

NF-κB dependent and independent mechanisms of quartz-induced proinflammatory activation of lung epithelial cells

(2010) Damien van Berlo et al.   Particle and Fibre Toxicology

Pathological Study of Acute Pulmonary Toxicity Induced by Intratracheally Instilled Asian Sand Dust (Kosa)

(2010) Misaki Naota et al.   TOXICOLOGIC PATHOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Co-cultures of multiple cell types mimic pulmonary cell communication in response to urban PM10

(2008) E. Alfaro-Moreno et al.   EUROPEAN RESPIRATORY JOURNAL

IL-1beta differently involved in IL-8 and FGF-2 release in crystalline silica-treated lung cell co-cultures

(2008) Jan I Herseth et al.   Particle and Fibre Toxicology

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

The ability of oxidative stress to mimic quartz-induced chemokine responses is lung cell line-dependent

(2008) J OVREVIK et al.   TOXICOLOGY LETTERS