Model Complexity as Determining Factor for In Vitro Nanosafety Studies: Effects of Silver and Titanium Dioxide Nanomaterials in Intestinal Models

Agglomeration of titanium dioxide nanoparticles increases toxicological responses in vitro and in vivo

(2020) Sivakumar Murugadoss et al.   Particle and Fibre Toxicology

Nanotechnologies in Food Science: Applications, Recent Trends, and Future Perspectives

(2020) Shivraj Hariram Nile et al.   Nano-Micro Letters

A novel 3D intestine barrier model to study the immune response upon exposure to microplastics

(2020) Roman Lehner et al.   ARCHIVES OF TOXICOLOGY

Nanomaterials and Innate Immunity: A Perspective of the Current Status in Nanosafety

(2020) James G. Cronin et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research

(2020) Angela A. M. Kämpfer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Transformation of Nanomaterials and Its Implications in Gut Nanotoxicology

(2020) Magdiel Inggrid Setyawati et al.   Small

Cell–cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro

(2019) Christine Wenz et al.   ARCHIVES OF TOXICOLOGY

Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression

(2019) Amira M. Abdelmegid et al.   Scientific Reports

Advances and Current Challenges in Intestinal in vitro Model Engineering: A Digest

(2019) Joana Costa et al.   Frontiers in Bioengineering and Biotechnology

Ongoing inflammation enhances the toxicity of engineered nanomaterials: Application of an in vitro co-culture model of the healthy and inflamed intestine

(2019) Angela A.M. Kämpfer et al.   TOXICOLOGY IN VITRO

Assessing the effects of silver nanoparticles on monolayers of differentiated Caco-2 cells, as a model of intestinal barrier

(2018) Laura Vila et al.   FOOD AND CHEMICAL TOXICOLOGY

Overt Increase of Oxidative Stress and DNA Damage in Murine and Human Colitis and Colitis-Associated Neoplasia

(2018) Adrian Frick et al.   MOLECULAR CANCER RESEARCH

Effects of differently shaped TiO2NPs (nanospheres, nanorods and nanowires) on the in vitro model (Caco-2/HT29) of the intestinal barrier

(2018) Alba García-Rodríguez et al.   Particle and Fibre Toxicology

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture

(2017) Isabel Lozoya-Agullo et al.   MOLECULAR PHARMACEUTICS

Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice

(2017) Sameera Nallanthighal et al.   Nanotoxicology

Impact of copper oxide nanomaterials on differentiated and undifferentiated Caco-2 intestinal epithelial cells; assessment of cytotoxicity, barrier integrity, cytokine production and nanomaterial penetration

(2017) Victor C. Ude et al.   Particle and Fibre Toxicology

The unrecognized occupational relevance of the interaction between engineered nanomaterials and the gastro-intestinal tract: a consensus paper from a multidisciplinary working group

(2017) Antonio Pietroiusti et al.   Particle and Fibre Toxicology

Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state

(2017) Angela A.M. Kämpfer et al.   TOXICOLOGY IN VITRO

Effects of food-borne nanomaterials on gastrointestinal tissues and microbiota

(2017) Hans Bouwmeester et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Food-grade TiO2 impairs intestinal and systemic immune homeostasis, initiates preneoplastic lesions and promotes aberrant crypt development in the rat colon

(2017) Sarah Bettini et al.   Scientific Reports

Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues

(2016) P. Lundquist et al.   ADVANCED DRUG DELIVERY REVIEWS

Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model

(2016) Ismael M. Urrutia-Ortega et al.   FOOD AND CHEMICAL TOXICOLOGY

Titanium dioxide nanoparticles exacerbate DSS-induced colitis: role of the NLRP3 inflammasome

(2016) Pedro A Ruiz et al.   GUT

DNA Damage and Oxidative DNA Damage in Inflammatory Bowel Disease

(2016) Cristiana Pereira et al.   Journal of Crohns & Colitis

Biological effect of food additive titanium dioxide nanoparticles on intestine: anin vitrostudy

(2015) Zheng-Mei Song et al.   JOURNAL OF APPLIED TOXICOLOGY

Mucosal Barrier Depletion and Loss of Bacterial Diversity are Primary Abnormalities in Paediatric Ulcerative Colitis

(2015) Misagh Alipour et al.   Journal of Crohns & Colitis

A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents

(2015) Ilka Maschmeyer et al.   LAB ON A CHIP

New developments in goblet cell mucus secretion and function

(2015) G M H Birchenough et al.   Mucosal Immunology

Effects of silver nanoparticles and ions on a co-culture model for the gastrointestinal epithelium

(2015) Anastasia Georgantzopoulou et al.   Particle and Fibre Toxicology

Dietary silver nanoparticles can disturb the gut microbiota in mice

(2015) Sybille van den Brule et al.   Particle and Fibre Toxicology

Cyto- and genotoxic effects of metallic nanoparticles in untransformed human fibroblast

(2015) Leonardo P. Franchi et al.   TOXICOLOGY IN VITRO

Oxidative stress-mediated inhibition of intestinal epithelial cell proliferation by silver nanoparticles

(2015) Christie McCracken et al.   TOXICOLOGY IN VITRO

Can the comet assay be used reliably to detect nanoparticle-induced genotoxicity?

(2014) Hanna L. Karlsson et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Silver nanoparticle-induced oxidative stress-dependent toxicity in Sprague-Dawley rats

(2014) Anita K. Patlolla et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Translocation of differently sized and charged polystyrene nanoparticles in in vitro intestinal cell models of increasing complexity

(2014) Agata P. Walczak et al.   Nanotoxicology

Oral ingestion of silver nanoparticles induces genomic instability and DNA damage in multiple tissues

(2014) Prasad Kovvuru et al.   Nanotoxicology

Cell uptake and oral absorption of titanium dioxide nanoparticles

(2014) G. Janer et al.   TOXICOLOGY LETTERS

Biopersistence of silver nanoparticles in tissues from Sprague–Dawley rats

(2013) Ji Lee et al.   Particle and Fibre Toxicology

Titanium dioxide nanoparticles: a review of current toxicological data

(2013) Hongbo Shi et al.   Particle and Fibre Toxicology

Distribution, Elimination, and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-Day Oral Exposure

(2012) Meike van der Zande et al.   ACS Nano

Cytotoxicity of peptide-coated silver nanoparticles on the human intestinal cell line Caco-2

(2012) Linda Böhmert et al.   ARCHIVES OF TOXICOLOGY

Distinctive Toxicity of TiO2 Rutile/Anatase Mixed Phase Nanoparticles on Caco-2 Cells

(2012) Kirsten Gerloff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nano- and microscaled particles for drug targeting to inflamed intestinal mucosa—A first in vivo study in human patients

(2012) Carsten Schmidt et al.   JOURNAL OF CONTROLLED RELEASE

Influence of simulated gastrointestinal conditions on particle-induced cytotoxicity and interleukin-8 regulation in differentiated and undifferentiated Caco-2 cells

(2012) Kirsten Gerloff et al.   Nanotoxicology

Oral exposure to polystyrene nanoparticles affects iron absorption

(2012) Gretchen J. Mahler et al.   Nature Nanotechnology

Titanium dioxide induced inflammation in the small intestine

(2012) Carolina Maciel Nogueira   WORLD JOURNAL OF GASTROENTEROLOGY

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

Induction of Glutathione Peroxidase 4 Expression during Enterocytic Cell Differentiation

(2011) Bodo Speckmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Size and surface charge of gold nanoparticles determine absorption across intestinal barriers and accumulation in secondary target organs after oral administration

(2011) Carsten Schleh et al.   Nanotoxicology

Barrier Properties of Gastrointestinal Mucus to Nanoparticle Transport

(2010) Jason S. Crater et al.   MACROMOLECULAR BIOSCIENCE

Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

(2009) B. Trouiller et al.   CANCER RESEARCH

Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells

(2009) Kirsten Gerloff et al.   Nanotoxicology

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Aberrant Expression of MUC1 Mucin in Pediatric Inflammatory Bowel Disease

(2008) Anna E. Furr et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY