Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS

Regulation of acetylcholinesterase during the lipopolysaccharide‐induced inflammatory responses in microglial cells

(2022) Yingjie Xia et al.   FASEB JOURNAL

Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis

(2022) Simon Witzel et al.   JAMA Neurology

Effects of PB‐TURSO on the transcriptional and metabolic landscape of sporadic ALS fibroblasts

(2022) Jasmine A. Fels et al.   Annals of Clinical and Translational Neurology

Riluzole does not ameliorate disease caused by cytoplasmic TDP‐43 in a mouse model of amyotrophic lateral sclerosis

(2021) Amanda L. Wright et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Donepezil Regulates LPS and Aβ-Stimulated Neuroinflammation through MAPK/NLRP3 Inflammasome/STAT3 Signaling

(2021) Jieun Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

(2020) Myung Geun Kook et al.   Scientific Reports

Protective Effect of Edaravone Against Oxidative Stress in C2C12 Myoblast and Impairment of Skeletal Muscle Regeneration Exposed to Ischemic Injury in Ob/ob Mice

(2020) Takuya Nakanishi et al.   Frontiers in Physiology

MicroRNA-153 improves the neurogenesis of neural stem cells and enhances the cognitive ability of aged mice through the notch signaling pathway

(2019) Jing Qiao et al.   CELL DEATH AND DIFFERENTIATION

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

(2018) Alex McCampbell et al.   JOURNAL OF CLINICAL INVESTIGATION

Factors that influence adult neurogenesis as potential therapy

(2018) Belal Shohayeb et al.   Translational Neurodegeneration

Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs

(2018) Manoj Kumar Jaiswal   MEDICINAL RESEARCH REVIEWS

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

(2018) Koki Fujimori et al.   NATURE MEDICINE

Enhanced oxidative stress and the treatment by edaravone in mice model of amyotrophic lateral sclerosis

(2018) Yasuyuki Ohta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis

(2017) Valentina Cappello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Drug therapy: On the treatment trail for ALS

(2017) Andrew Scott   NATURE

ALS Clinical Trials Review: 20 Years of Failure. Are We Any Closer to Registering a New Treatment?

(2017) Dmitry Petrov et al.   Frontiers in Aging Neuroscience

Role of Neuroinflammation in Amyotrophic Lateral Sclerosis: Cellular Mechanisms and Therapeutic Implications

(2017) Jia Liu et al.   Frontiers in Immunology

CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

(2017) James B. Hilton et al.   Scientific Reports

Increased peripheral blood inflammatory cytokine levels in amyotrophic lateral sclerosis: a meta-analysis study

(2017) Yang Hu et al.   Scientific Reports

Therapeutic progress in amyotrophic lateral sclerosis-beginning to learning

(2016) Vijay Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Increased oxidative stress in patients with amyotrophic lateral sclerosis and the effect of edaravone administration

(2016) Midori Nagase et al.   REDOX REPORT

C9orf72 Hexanucleotide Expansions Are Associated with Altered Endoplasmic Reticulum Calcium Homeostasis and Stress Granule Formation in Induced Pluripotent Stem Cell-Derived Neurons from Patients with Amyotrophic Lateral Sclerosis and Frontotemporal Demen

(2016) Ruxandra Dafinca et al.   STEM CELLS

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles

(2016) Marçal Vilar et al.   Frontiers in Neuroscience

C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis

(2015) Johnathan Cooper-Knock et al.   PLoS One

Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis

(2014) Min Yang et al.   CYTOKINE

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Loss of nuclear TDP-43 in amyotrophic lateral sclerosis (ALS) causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurones

(2014) J. Robin Highley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

New therapy options for amyotrophic lateral sclerosis

(2013) Paul Gordon et al.   EXPERT OPINION ON PHARMACOTHERAPY

Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

(2013) Bradley J. Turner et al.   NEUROBIOLOGY OF AGING

Stimulation of central β2-adrenoceptors suppresses NFκB activity in rat brain: A role for IκB

(2013) Katie J. Ryan et al.   NEUROCHEMISTRY INTERNATIONAL

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1G93Amouse model of amyotrophic lateral sclerosis

(2012) Bruce J. Lerman et al.   Brain and Behavior

Phosphatase and tensin homologue/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis

(2011) Janine Kirby et al.   BRAIN

Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways

(2011) Vivek Swarup et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells

(2010) Yun Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The β2-adrenoceptor agonist clenbuterol elicits neuroprotective, anti-inflammatory and neurotrophic actions in the kainic acid model of excitotoxicity

(2010) Lorna C. Gleeson et al.   BRAIN BEHAVIOR AND IMMUNITY

Role of nitric oxide produced by iNOS through NF-κB pathway in migration of cerebellar granule neurons induced by Lipopolysaccharide

(2010) Daniela Arias-Salvatierra et al.   CELLULAR SIGNALLING

Anabolic and catabolic pathways regulating skeletal muscle mass

(2010) John J McCarthy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand ?

(2010) Henriques   Frontiers in Neuroscience

Redox Modifier Genes and Pathways in Amyotrophic Lateral Sclerosis

(2009) Barrie J. Carter et al.   ANTIOXIDANTS & REDOX SIGNALING

Astrocyte function and role in motor neuron disease: A future therapeutic target?

(2009) Daniel Blackburn et al.   GLIA

Sporadic ALS has compartment-specific aberrant exon splicing and altered cell–matrix adhesion biology

(2009) Stuart J. Rabin et al.   HUMAN MOLECULAR GENETICS

ACh receptors link two signaling pathways to neuroprotection against glutamate-induced excitotoxicity in isolated RGCs

(2009) Chinwe O. Asomugha et al.   JOURNAL OF NEUROCHEMISTRY

Immune system alterations in sporadic amyotrophic lateral sclerosis patients suggest an ongoing neuroinflammatory process

(2009) Stefania Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

Nuclear Contour Irregularity and Abnormal Transporter Protein Distribution in Anterior Horn Cells in Amyotrophic Lateral Sclerosis

(2009) Yoshimi Kinoshita et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Calcium signaling in neurodegeneration

(2009) Philippe Marambaud et al.   Molecular Neurodegeneration

Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

(2009) Isabella Palazzolo et al.   NEURON

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Retrograde axonal transport and motor neuron disease

(2008) Anna-Lena Strm et al.   JOURNAL OF NEUROCHEMISTRY

Delivery of AAV-IGF-1 to the CNS Extends Survival in ALS Mice Through Modification of Aberrant Glial Cell Activity

(2008) James C Dodge et al.   MOLECULAR THERAPY

Subcutaneous IGF-1 is not beneficial in 2-year ALS trial

(2008) E. J. Sorenson et al.   NEUROLOGY