Neuromuscular Junction Dismantling in Amyotrophic Lateral Sclerosis

Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia

(2017) Deepti Lall et al.   JOURNAL OF CLINICAL INVESTIGATION

Potential therapeutic targets for ALS: MIR206, MIR208b and MIR499 are modulated during disease progression in the skeletal muscle of patients

(2017) Lorena Di Pietro et al.   Scientific Reports

Genetics of Amyotrophic Lateral Sclerosis

(2017) Mehdi Ghasemi et al.   Cold Spring Harbor Perspectives in Medicine

Loss of adult skeletal muscle stem cells drives age-related neuromuscular junction degeneration

(2017) Wenxuan Liu et al.   eLife

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo

(2017) Kun Qian et al.   Stem Cell Reports

Augmented quantal release of acetylcholine at the vertebrate neuromuscular junction following tdp-43 depletion

(2017) Stefania Dzieciolowska et al.   PLoS One

The Role of Skeletal Muscle in Amyotrophic Lateral Sclerosis

(2016) Jean-Philippe Loeffler et al.   BRAIN PATHOLOGY

Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease

(2016) Dario I. Carrasco et al.   EXPERIMENTAL NEUROLOGY

Altered terminal Schwann cell morphology precedes denervation in SOD1 mice

(2016) Dario I. Carrasco et al.   EXPERIMENTAL NEUROLOGY

Axonal degeneration, distal collateral branching and neuromuscular junction architecture alterations occur prior to symptom onset in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2016) Jayden A. Clark et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Muscle Fibers Secrete FGFBP1 to Slow Degeneration of Neuromuscular Synapses during Aging and Progression of ALS

(2016) Thomas Taetzsch et al.   JOURNAL OF NEUROSCIENCE

Schwann Cells in Neuromuscular Junction Formation and Maintenance

(2016) A. Barik et al.   JOURNAL OF NEUROSCIENCE

New perspectives on amyotrophic lateral sclerosis: the role of glial cells at the neuromuscular junction

(2016) Danielle Arbour et al.   JOURNAL OF PHYSIOLOGY-LONDON

The ageing neuromuscular system and sarcopenia: a mitochondrial perspective

(2016) Karolina A. Rygiel et al.   JOURNAL OF PHYSIOLOGY-LONDON

Acetylcholine receptors from human muscle as pharmacological targets for ALS therapy

(2016) Eleonora Palma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

(2016) Maria-Letizia Campanari et al.   Frontiers in Molecular Neuroscience

Failed reinnervation in aging skeletal muscle

(2016) Sudhakar Aare et al.   Skeletal Muscle

VAChT overexpression increases acetylcholine at the synaptic cleft and accelerates aging of neuromuscular junctions

(2016) Satoshi Sugita et al.   Skeletal Muscle

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

(2016) Jurate Lasiene et al.   Acta Neuropathologica Communications

INaP selective inhibition reverts precocious inter- and motorneurons hyperexcitability in the Sod1-G93R zebrafish ALS model

(2016) Lorena Benedetti et al.   Scientific Reports

Human-derived neural progenitors functionally replace astrocytes in adult mice

(2015) Hong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Early and Persistent Abnormal Decoding by Glial Cells at the Neuromuscular Junction in an ALS Model

(2015) D. Arbour et al.   JOURNAL OF NEUROSCIENCE

Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment

(2015) Andrew G Engel et al.   LANCET NEUROLOGY

Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

(2015) Lionel A. Tintignac et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial alarmins released by degenerating motor axon terminals activate perisynaptic Schwann cells

(2015) Elisa Duregotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Perisynaptic Schwann Cells at the Neuromuscular Synapse: Adaptable, Multitasking Glial Cells

(2015) Chien-Ping Ko et al.   Cold Spring Harbor Perspectives in Biology

Inducible depletion of adult skeletal muscle stem cells impairs the regeneration of neuromuscular junctions

(2015) Wenxuan Liu et al.   eLife

Anti-Ganglioside Antibodies in Amyotrophic Lateral Sclerosis Revisited

(2015) Katja Kollewe et al.   PLoS One

The Glutamate Hypothesis in ALS: Pathophysiology and Drug Development

(2014) H. Blasco et al.   CURRENT MEDICINAL CHEMISTRY

Interaction Between Bone and Muscle in Older Persons with Mobility Limitations

(2014) L. Ferrucci et al.   CURRENT PHARMACEUTICAL DESIGN

Glial cells in amyotrophic lateral sclerosis

(2014) T. Philips et al.   EXPERIMENTAL NEUROLOGY

Abnormal Intracellular Calcium Signaling and SNARE-Dependent Exocytosis Contributes to SOD1G93A Astrocyte-Mediated Toxicity in Amyotrophic Lateral Sclerosis

(2014) H. Kawamata et al.   JOURNAL OF NEUROSCIENCE

Terminal Schwann Cells Participate in Neuromuscular Synapse Remodeling during Reinnervation following Nerve Injury

(2014) H. Kang et al.   JOURNAL OF NEUROSCIENCE

An explant muscle model to examine the refinement of the synaptic landscape

(2014) Martin Gartz Hanson et al.   JOURNAL OF NEUROSCIENCE METHODS

Neuromuscular synaptogenesis: coordinating partners with multiple functions

(2014) Houssam Darabid et al.   NATURE REVIEWS NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Zebrafish models of human motor neuron diseases: Advantages and limitations

(2014) Patrick J. Babin et al.   PROGRESS IN NEUROBIOLOGY

Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies

(2014) Steve Vucic et al.   TRENDS IN NEUROSCIENCES

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle

(2014) Marta Gonzalez-Freire et al.   Frontiers in Aging Neuroscience

ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

(2014) Elizabeth B. Moloney et al.   Frontiers in Neuroscience

ERBB4 Mutations that Disrupt the Neuregulin-ErbB4 Pathway Cause Amyotrophic Lateral Sclerosis Type 19

(2013) Yuji Takahashi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?

(2013) H Muyderman et al.   BRITISH JOURNAL OF PHARMACOLOGY

The multifaceted role of glial cells in amyotrophic lateral sclerosis

(2013) Chiara F. Valori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Motor Axon Regeneration and Muscle Reinnervation in Young Adult and Aged Animals

(2013) H. Kang et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, motor neurons and aging

(2013) M.L. García et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Amyotrophic Lateral Sclerosis and Skeletal Muscle: An Update

(2013) O. Pansarasa et al.   MOLECULAR NEUROBIOLOGY

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Amyotrophic lateral sclerosis—a model of corticofugal axonal spread

(2013) Heiko Braak et al.   Nature Reviews Neurology

The epidemiology of ALS: a conspiracy of genes, environment and time

(2013) Ammar Al-Chalabi et al.   Nature Reviews Neurology

Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction

(2013) Sepehr Bahadorani et al.   NEUROBIOLOGY OF AGING

Human superoxide dismutase 1 overexpression in motor neurons of Caenorhabditis elegans causes axon guidance defect and neurodegeneration

(2013) Jia Li et al.   NEUROBIOLOGY OF AGING

ALS and Oxidative Stress: The Neurovascular Scenario

(2013) Akshay Anand et al.   Oxidative Medicine and Cellular Longevity

Early Changes of Neuromuscular Transmission in the SOD1(G93A) Mice Model of ALS Start Long before Motor Symptoms Onset

(2013) Mariana C. Rocha et al.   PLoS One

Defective Mitochondrial Dynamics Is an Early Event in Skeletal Muscle of an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Guo Luo et al.   PLoS One

The Role of MuSK in Synapse Formation and Neuromuscular Disease

(2013) S. J. Burden et al.   Cold Spring Harbor Perspectives in Biology

Active zones of mammalian neuromuscular junctions: formation, density, and aging

(2012) Hiroshi Nishimune   Annals of the New York Academy of Sciences

Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS

(2012) Sandrine Da Cruz et al.   Cell Metabolism

Aging and muscle

(2012) Todd M. Manini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Aging and the Energetic Cost of Life

(2012) Luigi Ferrucci et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Genomic and Proteomic Profiling Reveals Reduced Mitochondrial Function and Disruption of the Neuromuscular Junction Driving Rat Sarcopenia

(2012) C. Ibebunjo et al.   MOLECULAR AND CELLULAR BIOLOGY

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

(2012) Valentina Cappello et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Motor neuron apoptosis and neuromuscular junction perturbation are prominent features in a Drosophila model of Fus-mediated ALS

(2012) Ruohan Xia et al.   Molecular Neurodegeneration

Denervation Causes Fiber Atrophy and Myosin Heavy Chain Co-Expression in Senescent Skeletal Muscle

(2012) Sharon L. Rowan et al.   PLoS One

Role of extracellular matrix proteins and their receptors in the development of the vertebrate neuromuscular junction

(2011) Neha Singhal et al.   Developmental Neurobiology

Hind limb muscle atrophy precedes cerebral neuronal degeneration in G93A-SOD1 mouse model of amyotrophic lateral sclerosis: A longitudinal MRI study

(2011) Stefania Marcuzzo et al.   EXPERIMENTAL NEUROLOGY

Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia

(2011) Lukas Bütikofer et al.   FASEB JOURNAL

Physiological characterization of human muscle acetylcholine receptors from ALS patients

(2011) E. Palma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

To build a synapse: signaling pathways in neuromuscular junction assembly

(2010) H. Wu et al.   DEVELOPMENT

Remodeling of the neuromuscular junction precedes sarcopenia related alterations in myofibers

(2010) Michael R. Deschenes et al.   EXPERIMENTAL GERONTOLOGY

Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice

(2010) Margaret Wong et al.   HUMAN MOLECULAR GENETICS

Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise

(2010) G. Valdez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells

(2009) A. Florence Keller et al.   GLIA

Dismutase-competent SOD1 mutant accumulation in myelinating Schwann cells is not detrimental to normal or transgenic ALS model mice

(2009) B. J. Turner et al.   HUMAN MOLECULAR GENETICS

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans

(2009) Jiou Wang et al.   PLoS Genetics

ADrosophilaModel for Amyotrophic Lateral Sclerosis Reveals Motor Neuron Damage by Human SOD1

(2008) Melanie R. Watson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

(2008) D. Jaarsma et al.   JOURNAL OF NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Local expression of mIgf-1 modulates ubiquitin, caspase and CDK5 expression in skeletal muscle of an ALS mouse model

(2008) Gabriella Dobrowolny et al.   NEUROLOGICAL RESEARCH

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY