CuII(atsm) improves the neurological phenotype and survival of SOD1G93A mice and selectively increases enzymatically active SOD1 in the spinal cord

Endogenous Cu in the central nervous system fails to satiate the elevated requirement for Cu in a mutant SOD1 mouse model of ALS

(2016) J. B. Hilton et al.   Metallomics

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SODG93A mice co-expressing the Copper-Chaperone-for-SOD

(2016) Jared R. Williams et al.   NEUROBIOLOGY OF DISEASE

Polyamines Stimulate the Level of the σ38Subunit (RpoS) ofEscherichia coliRNA Polymerase, Resulting in the Induction of the Glutamate Decarboxylase-dependent Acid Response System via thegadERegulon

(2015) Manas K. Chattopadhyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metal-deficient SOD1 in amyotrophic lateral sclerosis

(2015) James B. Hilton et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study

(2015) M. Ikawa et al.   NEUROLOGY

Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis

(2014) Wenzhi Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oral Treatment with CuII(atsm) Increases Mutant SOD1 In Vivo but Protects Motor Neurons and Improves the Phenotype of a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis

(2014) B. R. Roberts et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis

(2014) Piia Vehviläinen et al.   Frontiers in Cellular Neuroscience

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

Dysregulation of intracellular copper homeostasis is common to transgenic mice expressing human mutant superoxide dismutase-1s regardless of their copper-binding abilities

(2013) Eiichi Tokuda et al.   NEUROBIOLOGY OF DISEASE

Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis

(2013) Vikram Khipple Mulligan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis

(2013) Erin J. McAllum et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis

(2012) K. S. Graffmo et al.   HUMAN MOLECULAR GENETICS

The hypoxia imaging agent Cu II (atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease

(2012) Lin W. Hung et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Measuring copper and zinc superoxide dismutase from spinal cord tissue using electrospray mass spectrometry

(2011) Timothy W. Rhoads et al.   ANALYTICAL BIOCHEMISTRY

Diacetylbis(N(4)-methylthiosemicarbazonato) Copper(II) (CuII(atsm)) Protects against Peroxynitrite-induced Nitrosative Damage and Prolongs Survival in Amyotrophic Lateral Sclerosis Mouse Model

(2011) Cynthia P. W. Soon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ALS-Causing SOD1 Mutations Promote Production of Copper-Deficient Misfolded Species

(2011) Philbert Ip et al.   JOURNAL OF MOLECULAR BIOLOGY

Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET

(2011) Masamichi Ikawa et al.   NUCLEAR MEDICINE AND BIOLOGY

Radiolabeled Cu-ATSM as a novel indicator of overreduced intracellular state due to mitochondrial dysfunction: studies with mitochondrial DNA-less ρ0 cells and cybrids carrying MELAS mitochondrial DNA mutation

(2011) Yukie Yoshii et al.   NUCLEAR MEDICINE AND BIOLOGY

An impaired mitochondrial electron transport chain increases retention of the hypoxia imaging agent diacetylbis(4-methylthiosemicarbazonato)copperII

(2011) P. S. Donnelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS

(2010) Daryl A Bosco et al.   NATURE NEUROSCIENCE

Dysregulation of intracellular copper trafficking pathway in a mouse model of mutant copper/zinc superoxide dismutase-linked familial amyotrophic lateral sclerosis

(2009) Eiichi Tokuda et al.   JOURNAL OF NEUROCHEMISTRY

PET imaging of redox and energy states in stroke-like episodes of MELAS

(2009) Masamichi Ikawa et al.   MITOCHONDRION

Ammonium tetrathiomolybdate delays onset, prolongs survival, and slows progression of disease in a mouse model for amyotrophic lateral sclerosis

(2008) Eiichi Tokuda et al.   EXPERIMENTAL NEUROLOGY

Unfolding and Folding Kinetics of Amyotrophic Lateral Sclerosis-Associated Mutant Cu,Zn Superoxide Dismutases

(2008) Jessica A.O. Rumfeldt et al.   JOURNAL OF MOLECULAR BIOLOGY