New therapy options for amyotrophic lateral sclerosis

C9orf72 repeat expansions are a rare genetic cause of parkinsonism

(2013) Suzanne Lesage et al.   BRAIN

Hypolipidemia in Patients with Amyotrophic Lateral Sclerosis: A Possible Gender Difference?

(2013) Ji Won Yang et al.   Journal of Clinical Neurology

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

(2013) Timothy M Miller et al.   LANCET NEUROLOGY

Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis

(2012) Jeremy Shefner et al.   Amyotrophic Lateral Sclerosis

Visual Observations of an American Patient With Leber Hereditary Optic Neuropathy After Purported Injections of Stem Cells in China

(2012) Byron L. Lam   ARCHIVES OF OPHTHALMOLOGY

The role of Nogo-A in neuroregeneration: A review

(2012) Tao Wang et al.   BRAIN RESEARCH BULLETIN

Corticobasal and ataxia syndromes widen the spectrum ofC9ORF72hexanucleotide expansion disease

(2012) SG Lindquist et al.   CLINICAL GENETICS

Physical fitness and amyotrophic lateral sclerosis: dangerous liaisons or common genetic pathways?

(2012) Adriano Chiò et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study

(2012) Susan Byrne et al.   LANCET NEUROLOGY

Mutations in the profilin 1 gene cause familial amyotrophic lateral sclerosis

(2012) Chi-Hong Wu et al.   NATURE

Is hyperlipidemia correlated with longer survival in patients with amyotrophic lateral sclerosis?

(2012) Svetlana I Kostic Dedic et al.   NEUROLOGICAL RESEARCH

Phenotype and genotype analysis in amyotrophic lateral sclerosis with TARDBP gene mutations

(2012) P. Corcia et al.   NEUROLOGY

Neurotrophic Bone Marrow Cellular Nests Prevent Spinal Motoneuron Degeneration in Amyotrophic Lateral Sclerosis Patients: A Pilot Safety Study

(2012) Miguel Blanquer et al.   STEM CELLS

Lumbar Intraspinal Injection of Neural Stem Cells in Patients with Amyotrophic Lateral Sclerosis: Results of a Phase I Trial in 12 Patients

(2012) Jonathan D. Glass et al.   STEM CELLS

Antisense oligonucleotide therapeutics for inherited neurodegenerative diseases

(2012) Amber L. Southwell et al.   TRENDS IN MOLECULAR MEDICINE

SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy

(2012) Leah Winer et al.   JAMA Neurology

Downregulation of VAPB expression in motor neurons derived from induced pluripotent stem cells of ALS8 patients

(2011) Miguel Mitne-Neto et al.   HUMAN MOLECULAR GENETICS

Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis

(2011) N. A. Sutedja et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cardiovascular fitness as a risk factor for amyotrophic lateral sclerosis: indirect evidence from record linkage study: Table 1

(2011) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Induced pluripotent stem cells: a new revolution for clinical neurology?

(2011) Virginia B Mattis et al.   LANCET NEUROLOGY

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

(2011) Sabrina Paganoni et al.   MUSCLE & NERVE

How can we improve clinical trials in amyotrophic lateral sclerosis?

(2011) Paul H. Gordon et al.   Nature Reviews Neurology

Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

(2011) Peter M. Andersen et al.   Nature Reviews Neurology

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Comparative Effects between Bone Marrow and Mesenchymal Stem Cell Transplantation in GDNF Expression and Motor Function Recovery in a Motorneuron Degenerative Mouse Model

(2011) Diego Pastor et al.   Stem Cell Reviews and Reports

Human Motor Neuron Progenitor Transplantation Leads to Endogenous Neuronal Sparing in 3 Models of Motor Neuron Loss

(2011) Tanya J. Wyatt et al.   Stem Cells International

Stem cells and the ALS neurologist

(2010) Nicholas J. Maragakis   Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

(2010) Ettore Beghi et al.   Amyotrophic Lateral Sclerosis

Guidelines for preclinical animal research in ALS/MND: A consensus meeting

(2010) Albert C. Ludolph et al.   Amyotrophic Lateral Sclerosis

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Cellular transplants in amyotrophic lateral sclerosis patients: an observational study

(2010) Josep Gamez et al.   CYTOTHERAPY

SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations

(2010) S. Millecamps et al.   JOURNAL OF MEDICAL GENETICS

Physical fitness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age

(2010) Peter Mattsson et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Energy metabolism in amyotrophic lateral sclerosis

(2010) Luc Dupuis et al.   LANCET NEUROLOGY

Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis

(2009) Shizuo Ohnishi et al.   BRAIN RESEARCH

Adult neural stem cells in the mammalian central nervous system

(2009) Dengke K Ma et al.   CELL RESEARCH

Recent advances in the genetics of amyotrophic lateral sclerosis

(2009) Paul N. Valdmanis et al.   Current Neurology and Neuroscience Reports

Neuromuscular junction destruction during amyotrophic lateral sclerosis: insights from transgenic models

(2009) Luc Dupuis et al.   CURRENT OPINION IN PHARMACOLOGY

Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial

(2009) L. Mazzini et al.   EXPERIMENTAL NEUROLOGY

Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitry

(2009) Leyan Xu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Chimerization of astroglial population in the lumbar spinal cord after mesenchymal stem cell transplantation prolongs survival in a rat model of amyotrophic lateral sclerosis

(2009) Cédric Boucherie et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Lower serum lipid levels are related to respiratory impairment in patients with ALS

(2009) A. Chio et al.   NEUROLOGY

ALS motor phenotype heterogeneity, focality, and spread: Deconstructing motor neuron degeneration

(2009) J. M. Ravits et al.   NEUROLOGY

Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice

(2009) Heejaung Kim et al.   NEUROSCIENCE LETTERS

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

(2009) A. H. Williams et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Directed Differentiation of Human-Induced Pluripotent Stem Cells Generates Active Motor Neurons

(2009) Saravanan Karumbayaram et al.   STEM CELLS

High metabolic level in patients with familial amyotrophic lateral sclerosis

(2008) Benoit Funalot et al.   Amyotrophic Lateral Sclerosis

Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up

(2008) H. Deda et al.   CYTOTHERAPY

Dyslipidemia is a protective factor in amyotrophic lateral sclerosis

(2008) L. Dupuis et al.   NEUROLOGY

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE