Repeated intramuscular transplantations of hUCB-MSCs improves motor function and survival in the SOD1 G93A mice through activation of AMPK

Mesenchymal Stem Cells: A Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis?

(2019) Agnese Gugliandolo et al.   Stem Cells International

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1G93A Rats

(2019) Monika Řehořová et al.   Stem Cells Translational Medicine

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

(2018) Derek T Hall et al.   EMBO Molecular Medicine

Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia

(2018) Johanna Ábrigo et al.   Oxidative Medicine and Cellular Longevity

The Role of AMPK in Neuromuscular Biology and Disease

(2018) Athan G. Dial et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

(2018) Zvi Cramer et al.   Scientific Reports

Repeated Intrathecal Mesenchymal Stem Cells for Amyotrophic Lateral Sclerosis

(2018) Ki-Wook Oh et al.   ANNALS OF NEUROLOGY

Antioxidant effect of human placenta hydrolysate against oxidative stress on muscle atrophy

(2018) Dong-ho Bak et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression

(2018) Yajuan Xiao et al.   PHARMACOLOGICAL RESEARCH

KCHO-1, a novel herbal anti-inflammatory compound, attenuates oxidative stress in an animal model of amyotrophic lateral sclerosis

(2017) Myung Geun Kook et al.   Journal of Veterinary Science

The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

(2017) Sebastian Peters et al.   Frontiers in Neurology

ALS skeletal muscle shows enhanced TGF-β signaling, fibrosis and induction of fibro/adipogenic progenitor markers

(2017) David Gonzalez et al.   PLoS One

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation

(2016) Johanna Ábrigo et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

(2016) Johanna Abrigo et al.   CELLULAR SIGNALLING

Recent advances in amyotrophic lateral sclerosis

(2016) Nilo Riva et al.   JOURNAL OF NEUROLOGY

Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis

(2016) Tae-Hoon Shin et al.   Cell Death & Disease

Safety and Clinical Effects of Mesenchymal Stem Cells Secreting Neurotrophic Factor Transplantation in Patients With Amyotrophic Lateral Sclerosis

(2016) Panayiota Petrou et al.   JAMA Neurology

Aberrant activation of AMP-activated protein kinase contributes to the abnormal distribution of HuR in amyotrophic lateral sclerosis

(2015) Yu-Ju Liu et al.   FEBS LETTERS

Umbilical cord mesenchymal stem cell-conditioned media prevent muscle atrophy by suppressing muscle atrophy-related proteins and ROS generation

(2015) Chan-Mi Park et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

“Preconditioning” with latrepirdine, an adenosine 5′-monophosphate-activated protein kinase activator, delays amyotrophic lateral sclerosis progression in SOD1G93A mice

(2015) Karen S. Coughlan et al.   NEUROBIOLOGY OF AGING

Transforming Growth Factor Beta (TGF-β) Is a Muscle Biomarker of Disease Progression in ALS and Correlates with Smad Expression

(2015) Ying Si et al.   PLoS One

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Activation of AMP-activated protein kinase α1 mediates mislocalization of TDP-43 in amyotrophic lateral sclerosis

(2014) Yu-Ju Liu et al.   HUMAN MOLECULAR GENETICS

LKB1 and AMPK regulate synaptic remodeling in old age

(2014) Melanie A Samuel et al.   NATURE NEUROSCIENCE

Resveratrol Improves Motoneuron Function and Extends Survival in SOD1G93A ALS Mice

(2014) Renzo Mancuso et al.   Neurotherapeutics

Mutant TDP-43 Deregulates AMPK Activation by PP2A in ALS Models

(2014) Nirma D. Perera et al.   PLoS One

Intrathecal Delivery of Mesenchymal Stromal Cells Protects the Structure of Altered Perineuronal Nets in SOD1 Rats and Amends the Course of ALS

(2014) Serhiy Forostyak et al.   STEM CELLS

Concise Review: Stem Cell Therapies for Amyotrophic Lateral Sclerosis: Recent Advances and Prospects for the Future

(2014) J. Simon Lunn et al.   STEM CELLS

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

Reduced Activity of AMP-Activated Protein Kinase Protects against Genetic Models of Motor Neuron Disease

(2012) M. A. Lim et al.   JOURNAL OF NEUROSCIENCE

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Protect against Neuronal Cell Death and Ameliorate Motor Deficits in Niemann Pick Type C1 Mice

(2011) Yoojin Seo et al.   CELL TRANSPLANTATION

Metformin Treatment Has No Beneficial Effect in a Dose-Response Survival Study in the SOD1G93A Mouse Model of ALS and Is Harmful in Female Mice

(2011) Hannah M. Kaneb et al.   PLoS One

Mesenchymal stem cells as anti-inflammatories: Implications for treatment of Duchenne muscular dystrophy

(2009) Thomas E. Ichim et al.   CELLULAR IMMUNOLOGY

Direct Muscle Delivery of GDNF With Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS

(2008) Masatoshi Suzuki et al.   MOLECULAR THERAPY