Memantine: Updating a rare success story in pro-cognitive therapeutics

Lecanemab: First Approval

(2023) Sheridan M. Hoy   DRUGS

Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease

(2023) Gil D. Rabinovici et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Ushering in a New Era of Alzheimer Disease Therapy

(2023) Eric W. Widera et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Donanemab in Early Symptomatic Alzheimer Disease

(2023) John R. Sims et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Lecanemab

(2023) James F. Burke et al.   NEUROLOGY

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019

(2022) Emma Nichols et al.   Lancet Public Health

Safety and Efficacy of Monoclonal Antibodies for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Published and Unpublished Clinical Trials

(2022) Eleonora Lacorte et al.   JOURNAL OF ALZHEIMERS DISEASE

Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice

(2022) Shigeki Moriguchi et al.   MOLECULAR NEUROBIOLOGY

Chondroitin sulfate proteoglycan is a potential target of memantine to improve cognitive function via the promotion of adult neurogenesis

(2022) Shoichiro Maeda et al.   BRITISH JOURNAL OF PHARMACOLOGY

NMDA receptor antagonists reduce amyloid-β deposition by modulating calpain-1 signaling and autophagy, rescuing cognitive impairment in 5XFAD mice

(2022) Júlia Companys-Alemany et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Pharmacotherapy of Alzheimer’s disease: an overview of systematic reviews

(2022) Reza Majidazar et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult

(2022) Yancy Ferrer-Acosta et al.   TOXICOLOGY IN VITRO

Inhibition of NMDA receptors through a membrane-to-channel path

(2022) Madeleine R. Wilcox et al.   Nature Communications

The pathogenic N650K variant in the GluN1 subunit regulates the trafficking, conductance, and pharmacological properties of NMDA receptors

(2022) Marharyta Kolcheva et al.   NEUROPHARMACOLOGY

Early onset severe ATP1A2 epileptic encephalopathy: Clinical characteristics and underlying mutations

(2021) Mary E. Moya-Mendez et al.   EPILEPSY & BEHAVIOR

The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer’s Dementia: A Double-Blind Randomized Placebo-Controlled Trial

(2021) HyunChul Youn et al.   Psychiatry Investigation

Effect of memantine, an anti-Alzheimer’s drug, on rodent microglial cells in vitro

(2021) Toru Murakawa-Hirachi et al.   Scientific Reports

Pathogenesis of sporadic Alzheimer's disease by deficiency of NMDA receptor subunit GluN3A

(2021) Weiwei Zhong et al.   Alzheimers & Dementia

Memantine ameliorates cognitive deficit in AD mice via enhancement of entorhinal–CA1 projection

(2021) Peng Li et al.   BMC NEUROSCIENCE

A tribute to Chris Parsons

(2021) Bruno Frenguelli et al.   NEUROPHARMACOLOGY

Spatial and latent memory data in PS2Tg2576 alzheimer's disease mouse model after memantine treatment

(2021) Masahisa Matsumura et al.   Data in Brief

Safety, efficacy, and tolerability of memantine for cognitive and adaptive outcome measures in adolescents and young adults with Down syndrome: a randomised, double-blind, placebo-controlled phase 2 trial

(2021) Alberto C S Costa et al.   LANCET NEUROLOGY

Memantine improves cognitive deficits via KATP channel inhibition in olfactory bulbectomized mice

(2021) Shigeki Moriguchi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astrocytic Kir4.1 regulates NMDAR/calpain signaling axis in lipopolysaccharide-induced depression-like behaviors in mice

(2021) Zhujin Song et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Aducanumab: European agency rejects Alzheimer’s drug over efficacy and safety concerns

(2021) Elisabeth Mahase   BMJ-British Medical Journal

Amantadine and memantine: a comprehensive review for acquired brain injury

(2020) Heather M. Ma et al.   BRAIN INJURY

Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients With Brain Metastases: Phase III Trial NRG Oncology CC001

(2020) Paul D. Brown et al.   JOURNAL OF CLINICAL ONCOLOGY

Dysregulation of BDNF/TrkB signaling mediated by NMDAR/Ca2+/calpain might contribute to postoperative cognitive dysfunction in aging mice

(2020) Li-Li Qiu et al.   Journal of Neuroinflammation

Withdrawal from Extended, Intermittent Access to A Highly Palatable Diet Impairs Hippocampal Memory Function and Neurogenesis: Effects of Memantine

(2020) Antonio Ferragud et al.   Nutrients

Dementia prevention, intervention, and care: 2020 report of the Lancet Commission

(2020) Gill Livingston et al.   LANCET

Effects of GluN2A and GluN2B gain-of-function epilepsy mutations on synaptic currents mediated by diheteromeric and triheteromeric NMDA receptors

(2020) Xiumin Chen et al.   NEUROBIOLOGY OF DISEASE

Maturation of newborn neurons predicts social memory persistence in mice

(2020) Laura F. Jaimes et al.   NEUROPHARMACOLOGY

Memantine ameliorates tau protein deposition and secondary damage in the ipsilateral thalamus and sensory decline following focal cortical infarction in rats

(2020) Yu-Bin Liang et al.   NEUROSCIENCE LETTERS

Patient Case Report

(2020) William J. Hayes et al.   CLINICAL NEUROPHARMACOLOGY

Chronic Memantine Treatment Ameliorates Behavioral Deficits, Neuron Loss, and Impaired Neurogenesis in a Model of Alzheimer’s Disease

(2020) Martina Stazi et al.   MOLECULAR NEUROBIOLOGY

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease

(2020) Giambattista Marotta et al.   MOLECULES

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

(2020) Gabriella Marucci et al.   NEUROPHARMACOLOGY

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of Kv1.3 potassium channels, AKT and ERK1/2 signaling

(2019) Theresa Lowinus et al.   Cell Communication and Signaling

Memantine and Acetylcholinesterase Inhibitor Use in Alzheimer’s Disease Clinical Trials: Potential for Confounding by Indication

(2019) Branko N. Huisa et al.   JOURNAL OF ALZHEIMERS DISEASE

A therapeutic dose of memantine improves the performance of rats in an active place avoidance task under the continuous dissociation of distal room and proximal arena cues

(2019) Malgorzata Wesierska et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Lactoferrin Coupled Lower Generation PAMAM Dendrimers for Brain Targeted Delivery of Memantine in Aluminum-Chloride-Induced Alzheimer’s Disease in Mice

(2019) Avinash Gothwal et al.   BIOCONJUGATE CHEMISTRY

Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

(2019) Feng Yi et al.   JOURNAL OF PHYSIOLOGY-LONDON

Improvement of PTSD-like behavior by the forgetting effect of hippocampal neurogenesis enhancer memantine in a social defeat stress paradigm

(2019) Rie Ishikawa et al.   Molecular Brain

The Concentration of Memantine in the Cerebrospinal Fluid of Alzheimer’s Disease Patients and Its Consequence to Oxidative Stress Biomarkers

(2019) Martin Valis et al.   Frontiers in Pharmacology

A combination of running and memantine increases neurogenesis and reduces activation of developmentally-born dentate granule neurons in rats

(2019) Shaina P. Cahill et al.   BEHAVIOURAL BRAIN RESEARCH

Memantine ER Maintains Patient Response in Moderate to Severe Alzheimer’s Disease

(2018) George T. Grossberg et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Monotherapy Is Good Enough for Patients With Mild-to-Moderate Alzheimer's Disease: A Network Meta-Analysis of 76 Randomized Controlled Trials

(2018) Kelvin K.F. Tsoi et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of the Glutamate NMDA Receptor Antagonist Memantine as Adjunctive Treatment in Borderline Personality Disorder: An Exploratory, Randomised, Double-Blind, Placebo-Controlled Trial

(2018) Jayashri Kulkarni et al.   CNS DRUGS

Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice

(2018) Ai Tanaka et al.   Journal of Stroke & Cerebrovascular Diseases

Peripheral and Central Effects of Memantine in a Mixed Preclinical Mice Model of Obesity and Familial Alzheimer’s Disease

(2018) Miren Ettcheto et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effects of topiramate and memantine in combination with hypothermia in hypoxic-ischemic brain injury in vitro and in vivo

(2018) Elisa Landucci et al.   NEUROSCIENCE LETTERS

Effectiveness of memantine on depression-like behavior, memory deficits and brain mRNA levels of BDNF and TrkB in rats subjected to repeated unpredictable stress

(2018) Meysam Amidfar et al.   Pharmacological Reports

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization

(2018) Elena Sánchez-López et al.   JOURNAL OF NANOBIOTECHNOLOGY

Effects of Memantine on Nitric Oxide Production and Hydroxyl Radical Metabolism during Cerebral Ischemia and Reperfusion in Mice

(2018) Ai Tanaka et al.   Journal of Stroke & Cerebrovascular Diseases

Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β

(2018) Sara R. Tanqueiro et al.   Frontiers in Pharmacology

The efficacy and safety of memantine for the treatment of Alzheimer’s disease

(2018) Shinji Matsunaga et al.   Expert Opinion On Drug Safety

Synergistic Effects of Antidementia Drugs on Spatial Learning and Recall in the APP23 Transgenic Mouse Model of Alzheimer's Disease

(2018) Katharina L. Neumeister et al.   JOURNAL OF ALZHEIMERS DISEASE

A Meta-Analysis of the Efficacy of Donepezil, Rivastigmine, Galantamine, and Memantine in Relation to Severity of Alzheimer's Disease

(2018) Simona Gabriella Di Santo et al.   JOURNAL OF ALZHEIMERS DISEASE

Efficacy and Safety of Donepezil, Galantamine, Rivastigmine, and Memantine for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis

(2018) Chen-Chen Tan et al.   JOURNAL OF ALZHEIMERS DISEASE

Mechanism of NMDA receptor channel block by MK-801 and memantine

(2018) Xianqiang Song et al.   NATURE

The NMDA receptor antagonist Radiprodil reverses the synaptotoxic effects of different amyloid-beta (Aβ) species on long-term potentiation (LTP)

(2018) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Differential Effects of Extended Exercise and Memantine Treatment on Adult Neurogenesis in Male and Female Rats

(2018) Shaina P. Cahill et al.   NEUROSCIENCE

Predictors of discontinuation, efficacy, and safety of memantine treatment for Alzheimer’s disease: meta-analysis and meta-regression of 18 randomized clinical trials involving 5004 patients

(2018) Lídia Blanco-Silvente et al.   BMC Geriatrics

Preservation of cognitive function following whole brain radiotherapy in patients with brain metastases: Complications, treatments, and the emerging role of memantine

(2018) Meghan Lynch   JOURNAL OF ONCOLOGY PHARMACY PRACTICE

Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials

(2018) Kai-Xin Dou et al.   Alzheimers Research & Therapy

Memantine reduces the production of amyloid-β peptides through modulation of amyloid precursor protein trafficking

(2017) Kaori Ito et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

An update on the advancements in the treatment of agitation in Alzheimer’s disease

(2017) Anton P. Porsteinsson et al.   EXPERT OPINION ON PHARMACOTHERAPY

Effect of Memantine on Serum Levels of Neuron-Specific Enolase and on the Glasgow Coma Scale in Patients With Moderate Traumatic Brain Injury

(2017) Majid Mokhtari et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Memantine and Ketamine Differentially Alter NMDA Receptor Desensitization

(2017) Nathan G. Glasgow et al.   JOURNAL OF NEUROSCIENCE

Memantine prevents acute radiation-induced toxicities at hippocampal excitatory synapses

(2017) Joseph G Duman et al.   NEURO-ONCOLOGY

Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus

(2017) Grace France et al.   NEUROPHARMACOLOGY

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

(2017) Daniela Puzzo et al.   eLife

Positive Modulatory Interactions of NMDA Receptor GluN1/2B Ligand Binding Domains Attenuate Antagonists Activity

(2017) Douglas Bledsoe et al.   Frontiers in Pharmacology

Effect of memantine on post-operative cognitive dysfunction after cardiac surgeries: a randomized clinical trial

(2017) Saba Ghaffary et al.   DARU-Journal of Pharmaceutical Sciences

Disease modification and Neuroprotection in neurodegenerative disorders

(2017) Jeffrey Cummings   Translational Neurodegeneration

Memantine Treatment in Patients with Mild to Moderate Alzheimer's Disease: Results of a Randomised, Double-Blind, Placebo-Controlled 6-Month Study

(2017) S. Bakchine et al.   JOURNAL OF ALZHEIMERS DISEASE

Folic Acid Potentiates the Effect of Memantine on Spatial Learning and Neuronal Protection in an Alzheimer's Disease Transgenic Model

(2017) Ta-Fu Chen et al.   JOURNAL OF ALZHEIMERS DISEASE

The combination of memantine and galantamine improves cognition in rats: The synergistic role of the α7 nicotinic acetylcholine and NMDA receptors

(2016) Agnieszka Nikiforuk et al.   BEHAVIOURAL BRAIN RESEARCH

MK-801 and memantine act differently on short-term memory tested with different time-intervals in the Morris water maze test

(2016) Weronika Duda et al.   BEHAVIOURAL BRAIN RESEARCH

Effects on agitation with rivastigmine patch monotherapy and combination therapy with memantine in mild to moderate Alzheimer's disease: a multicenter 24-week prospective randomized open-label study (the Korean EXelon Patch and combination with mEmantine

(2016) Soo J Yoon et al.   Geriatrics & Gerontology International

Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial)

(2016) Martin Knapp et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Neurogenesis Inhibition Prevents Enriched Environment to Prolong and Strengthen Social Recognition Memory, But Not to Increase BDNF Expression

(2016) Ana Raquel Pereira-Caixeta et al.   MOLECULAR NEUROBIOLOGY

Blockade of the KATP channel Kir6.2 by memantine represents a novel mechanism relevant to Alzheimer’s disease therapy

(2016) S Moriguchi et al.   MOLECULAR PSYCHIATRY

Emerging roles of GluN3-containing NMDA receptors in the CNS

(2016) Isabel Pérez-Otaño et al.   NATURE REVIEWS NEUROSCIENCE

Effects of memantine on the excitation-inhibition balance in prefrontal cortex

(2016) Nadezhda V. Povysheva et al.   NEUROBIOLOGY OF DISEASE

Memantine alters striatal plasticity inducing a shift of synaptic responses toward long-term depression

(2016) Maria Mancini et al.   NEUROPHARMACOLOGY

Cognitive benefits of memantine in Alzheimer's 5XFAD model mice decline during advanced disease stages

(2016) Latha Devi et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer’s Disease

(2016) Angelo M. Reggiani et al.   Scientific Reports

Memantine and reduced time with dyskinesia in Parkinson′s Disease

(2015) K. Wictorin et al.   ACTA NEUROLOGICA SCANDINAVICA

EFNS-ENS/EAN Guideline on concomitant use of cholinesterase inhibitors and memantine in moderate to severe Alzheimer's disease

(2015) R. Schmidt et al.   EUROPEAN JOURNAL OF NEUROLOGY

Anti-autophagic and anti-apoptotic effects of memantine in a SH-SY5Y cell model of Alzheimer's disease via mammalian target of rapamycin-dependent and -independent pathways

(2015) GUIJUN SONG et al.   Molecular Medicine Reports

Potencies and unblocking kinetic properties of antagonists at recombinant human NMDA receptors in a Xenopus oocytes model

(2015) Peter Heusler et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease

(2015) Alessandro Tozzi et al.   NEUROBIOLOGY OF AGING

Modification of Hippocampal Markers of Synaptic Plasticity by Memantine in Animal Models of Acute and Repeated Restraint Stress: Implications for Memory and Behavior

(2015) Shaimaa Nasr Amin et al.   NEUROMOLECULAR MEDICINE

Memantine Monotherapy for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2015) Shinji Matsunaga et al.   PLoS One

Memantine Attenuates Alzheimer’s Disease-Like Pathology and Cognitive Impairment

(2015) Xiaochuan Wang et al.   PLoS One

Improvement of a Woman’s Alcohol-Related Dementia via Off-label Memantine Treatment

(2014) Udo Bonnet et al.   ANNALS OF PHARMACOTHERAPY

Novel benzopolycyclic amines with NMDA receptor antagonist activity

(2014) Elena Valverde et al.   BIOORGANIC & MEDICINAL CHEMISTRY

NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells

(2014) Narasimhulu Simma et al.   Cell Communication and Signaling

Time-dependent enhancement of hippocampus-dependent memory after treatment with memantine: Implications for enhanced hippocampal adult neurogenesis

(2014) Rie Ishikawa et al.   HIPPOCAMPUS

Effect of Vitamin E and Memantine on Functional Decline in Alzheimer Disease

(2014) Maurice W. Dysken et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Pharmacological treatment of neuropsychiatric symptoms in Alzheimer's disease: a systematic review and meta-analysis

(2014) Jun Wang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Memantine improves spatial learning and memory impairments by regulating NGF signaling in APP/PS1 transgenic mice

(2014) M.Y. Liu et al.   NEUROSCIENCE

The impairment in spatial learning and hippocampal LTD induced through the PKA pathway in juvenile-onset diabetes rats are rescued by modulating NMDA receptor function

(2014) Hiroaki Sacai et al.   NEUROSCIENCE RESEARCH

Off-label Use of Memantine as Adjunctive Treatment in Schizophrenia: A Retrospective Case Series Study

(2014) J. John et al.   PHARMACOPSYCHIATRY

Investigating Glutamatergic Mechanism in Attention and Impulse Control Using Rats in a Modified 5-Choice Serial Reaction Time Task

(2014) Abigail Benn et al.   PLoS One

A 10-Week Memantine Treatment in Bipolar Depression: A Case Report. Focus on Depressive Symptomatology, Cognitive Parameters and Quality of Life

(2014) Dominik Strzelecki et al.   Psychiatry Investigation

Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

(2014) K. G. Akers et al.   SCIENCE

The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer’s Disease Drug Memantine

(2014) Chris Ulens et al.   STRUCTURE

Memantine prevents memory consolidation failure induced by soluble beta amyloid in rats

(2014) Paolo Tucci et al.   Frontiers in Behavioral Neuroscience

GRIN2Amutation and early-onset epileptic encephalopathy: personalized therapy with memantine

(2014) Tyler Mark Pierson et al.   Annals of Clinical and Translational Neurology

Insulin as a Bridge between Type 2 Diabetes and Alzheimer Disease – How Anti-Diabetics Could be a Solution for Dementia

(2014) Inês Sebastião et al.   Frontiers in Endocrinology

The Inhibition of Inwardly Rectifying K+Channels by Memantine in Macrophages and Microglial Cells

(2013) Ke-Li Tsai et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Safety, Tolerability, and Efficacy of Once-Daily Memantine (28 mg): A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients with Moderate-to-Severe Alzheimer’s Disease Taking Cholinesterase Inhibitors

(2013) George T. Grossberg et al.   CNS DRUGS

Comparison of the ex vivo receptor occupancy profile of ketamine to several NMDA receptor antagonists in mouse hippocampus

(2013) Brian Lord et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice

(2013) Julie Vignisse et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A randomized, double-blind, placebo-controlled trial of memantine in a behaviorally enriched sample of patients with moderate-to-severe Alzheimer's disease

(2013) Nathan Herrmann et al.   INTERNATIONAL PSYCHOGERIATRICS

Effects of Memantine on Clinical Ratings, Fluorodeoxyglucose Positron Emission Tomography Measurements, and Cerebrospinal Fluid Assays in Patients With Moderate to Severe Alzheimer Dementia

(2013) Tao Wang et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Memantine in patients with frontotemporal lobar degeneration: a multicentre, randomised, double-blind, placebo-controlled trial

(2013) Adam L Boxer et al.   LANCET NEUROLOGY

Immunosuppression byN-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of Kv1.3 and KCa3.1 Channels in T Cells

(2013) Sascha Kahlfuß et al.   MOLECULAR AND CELLULAR BIOLOGY

Modeling Alzheimer’s disease in transgenic rats

(2013) Sonia Do Carmo et al.   Molecular Neurodegeneration

In vitro mitochondrial failure and oxidative stress mimic biochemical features of Alzheimer disease

(2013) Rita Selvatici et al.   NEUROCHEMISTRY INTERNATIONAL

Okadaic acid-induced Tau phosphorylation in rat brain: Role of NMDA receptor

(2013) P.K. Kamat et al.   NEUROSCIENCE

Memantine protects cholinergic and glutamatergic septal neurons from Aβ1–40-induced toxicity

(2013) L.V. Colom et al.   NEUROSCIENCE LETTERS

Memantine and Cholinesterase Inhibitors: Complementary Mechanisms in the Treatment of Alzheimer’s Disease

(2013) Chris G. Parsons et al.   NEUROTOXICITY RESEARCH

A  induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss

(2013) M. Talantova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The potent effects of ginseng root extract and memantine on cognitive dysfunction in male albino rats

(2013) Mansour A Al-Hazmi et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

NMDA receptor-mediated excitotoxicity depends on the coactivation of synaptic and extrasynaptic receptors

(2013) X Zhou et al.   Cell Death & Disease

Low-dose memantine-induced working memory improvement in the allothetic place avoidance alternation task (APAAT) in young adult male rats

(2013) Malgorzata J. Wesierska et al.   Frontiers in Behavioral Neuroscience

Selective Pharmacological Modulation of Pyramidal Neurons and Interneurons in the CA1 Region of the Rat Hippocampus

(2013) Marzia Martina et al.   Frontiers in Pharmacology

False recognition in a mouse model of Alzheimer's disease: rescue with sensory restriction and memantine

(2012) C. Romberg et al.   BRAIN

Alzheimer's disease, β-amyloid, glutamate, NMDA receptors and memantine - searching for the connections

(2012) Wojciech Danysz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1–40

(2012) José Javier Miguel-Hidalgo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats

(2012) Pradeep Kumar Kamat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors

(2012) David W. McClymont et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine

(2012) Akira Nagakura et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer’s Disease

(2012) Elena Simoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

A study on neuroinflammation and NMDA receptor function in STZ (ICV) induced memory impaired rats

(2012) Shivika Rai et al.   JOURNAL OF NEUROIMMUNOLOGY

Memantine for axial signs in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot study

(2012) C. Moreau et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Synaptic NMDA Receptors Mediate Hypoxic Excitotoxic Death

(2012) C. M. Wroge et al.   JOURNAL OF NEUROSCIENCE

Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-Induced Amnesia in Mice

(2012) Perrine Busquet et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampusin vitro

(2012) Arturas Volianskis et al.   JOURNAL OF PHYSIOLOGY-LONDON

A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats

(2012) Pradeep Kumar Kamat et al.   LIFE SCIENCES

Targeting Synaptic Dysfunction in Alzheimer’s Disease Therapy

(2012) Robert Nisticò et al.   MOLECULAR NEUROBIOLOGY

Effects of memantine and galantamine on cognitive performance in aged rhesus macaques

(2012) Jay S. Schneider et al.   NEUROBIOLOGY OF AGING

A case of apathy due to frontotemporal dementia responsive to memantine

(2012) Kira A. Links et al.   NEUROCASE

Memantine potentiates hippocampal theta oscillations at a therapeutic dose in anesthetized mice: A mechanistic link to its cognitive-enhancing properties

(2012) Simone Guadagna et al.   NEUROPHARMACOLOGY

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

(2012) Andrew J. Thompson et al.   NEUROPHARMACOLOGY

Donepezil and Memantine for Moderate-to-Severe Alzheimer's Disease

(2012) Robert Howard et al.   NEW ENGLAND JOURNAL OF MEDICINE

Copper Chelator Induced Efficient Episodic Memory Recovery in a Non-Transgenic Alzheimer’s Mouse Model

(2012) Johnatan Ceccom et al.   PLoS One

Memantine and cholinesterase inhibitor combination therapy for Alzheimer's disease: a systematic review

(2012) Lucy E Farrimond et al.   BMJ Open

Lack of Evidence for the Efficacy of Memantine in Mild Alzheimer Disease

(2011) Lon S. Schneider   ARCHIVES OF NEUROLOGY

AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

(2011) Claire Thornton et al.   BIOCHEMICAL JOURNAL

Lithium, phenserine, memantine and pioglitazone reverse memory deficit and restore phospho-GSK3β decreased in hippocampus in intracerebroventricular streptozotocin induced memory deficit model

(2011) Teresa Ponce-Lopez et al.   BRAIN RESEARCH

Effects of memantine and donepezil on cortical and hippocampal acetylcholine levels and object recognition memory in rats

(2011) Jouni Ihalainen et al.   NEUROPHARMACOLOGY

Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices

(2011) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Subchronic memantine administration on spatial learning, exploratory activity, and nest-building in an APP/PS1 mouse model of Alzheimer’s disease

(2011) Mohammed Filali et al.   NEUROPHARMACOLOGY

Mitochondrial dysfunction: A crucial event in okadaic acid (ICV) induced memory impairment and apoptotic cell death in rat brain

(2011) Pradeep K. Kamat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

(2011) David Butler et al.   PLoS One

S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine

(2011) Matthias Vandesquille et al.   PSYCHOPHARMACOLOGY

Pharmacological modulation of contextual “episodic-like” memory in aged mice

(2010) C. Tronche et al.   BEHAVIOURAL BRAIN RESEARCH

In vivo evidence for functional NMDA receptor blockade by memantine in rat hippocampal neurons

(2010) Viktor Szegedi et al.   JOURNAL OF NEURAL TRANSMISSION

Memantine Preferentially Blocks Extrasynaptic over Synaptic NMDA Receptor Currents in Hippocampal Autapses

(2010) P. Xia et al.   JOURNAL OF NEUROSCIENCE

Cognition-Enhancing Properties of Dimebon in a Rat Novel Object Recognition Task Are Unlikely to Be Associated with Acetylcholinesterase Inhibition or N-Methyl-D-aspartate Receptor Antagonism

(2010) M. Giorgetti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Activation of Brain Histaminergic Neurotransmission: A Mechanism for Cognitive Effects of Memantine in Alzheimer's Disease

(2010) M. Motawaj et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transgenic Mouse Models of Alzheimer's Disease

(2010) Gregory A. Elder et al.   MOUNT SINAI JOURNAL OF MEDICINE

Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning

(2010) Teresa A. Barber et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Memantine depresses glutamate release through inhibition of voltage-dependent Ca2+ entry and protein kinase C in rat cerebral cortex nerve terminals: An NMDA receptor-independent mechanism

(2010) Cheng-Wei Lu et al.   NEUROCHEMISTRY INTERNATIONAL

Quantification of the Mg2+-induced potency shift of amantadine and memantine voltage-dependent block in human recombinant GluN1/GluN2A NMDARs

(2010) H.J. Otton et al.   NEUROPHARMACOLOGY

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

A within-subject cognitive battery in the rat: differential effects of NMDA receptor antagonists

(2010) Sophie Dix et al.   PSYCHOPHARMACOLOGY

E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat

(2010) Ian Kendall et al.   PSYCHOPHARMACOLOGY

Memantine Improves Cognition and Reduces Alzheimer’s-Like Neuropathology in Transgenic Mice

(2009) Hilda Martinez-Coria et al.   AMERICAN JOURNAL OF PATHOLOGY

Okadaic acid (ICV) induced memory impairment in rats: A suitable experimental model to test anti-dementia activity

(2009) Pradeep K. Kamat et al.   BRAIN RESEARCH

Pharmacological characterization of recombinant NR1/NR2A NMDA receptors with truncated and deleted carboxy termini expressed inXenopus laevisoocytes

(2009) CA Puddifoot et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of rat recombinant GluN1/GluN2A and GluN1/GluN2B NMDA receptors by ethanol at concentrations based on the US/UK drink-drive limit

(2009) Hannah J. Otton et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Memantine lowers amyloid-β peptide levels in neuronal cultures and in APP/PS1 transgenic mice

(2009) George M. Alley et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Memantine binding to a superficial site on NMDA receptors contributes to partial trapping

(2009) Shawn E. Kotermanski et al.   JOURNAL OF PHYSIOLOGY-LONDON

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Long-term treatment of l-3-n-butylphthalide attenuated neurodegenerative changes in aged rats

(2009) Shiping Ma et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Protection against Aβ-mediated rapid disruption of synaptic plasticity and memory by memantine

(2009) Igor Klyubin et al.   NEUROBIOLOGY OF AGING

Potency, voltage-dependency, agonist concentration-dependency, blocking kinetics and partial untrapping of the uncompetitive N-methyl-d-aspartate (NMDA) channel blocker memantine at human NMDA (GluN1/GluN2A) receptors

(2009) Kate E. Gilling et al.   NEUROPHARMACOLOGY

Effects of memantine on soluble Αβ25-35-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions

(2009) M. Arif et al.   NEUROSCIENCE

NMDA receptor antagonist memantine promotes cell proliferation and production of mature granule neurons in the adult hippocampus

(2009) Motoko Maekawa et al.   NEUROSCIENCE RESEARCH

The Excitotoxin Quinolinic Acid Induces Tau Phosphorylation in Human Neurons

(2009) Abdur Rahman et al.   PLoS One

Dual Action of Memantine in Alzheimer Disease: A Hypothesis

(2009) Tzong-Yuan Wu et al.   Taiwanese Journal of Obstetrics & Gynecology

Glutamate receptor-mediated restoration of experience-dependent place field expansion plasticity in aged rats.

(2008) Sara N. Burke et al.   BEHAVIORAL NEUROSCIENCE

Therapeutically relevant plasma concentrations of memantine produce significant L-N-methyl-D-aspartate receptor occupation and do not impair learning in rats

(2008) Lorenzo Morè et al.   BEHAVIOURAL PHARMACOLOGY

Bis(7)-tacrine prevents glutamate-induced excitotoxicity more potently than memantine by selectively inhibiting NMDA receptors

(2008) Yu-Wei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Memantine Potentiates Agonist-Induced Ca2+ Responses in HEK 293 Cells

(2008) Alexandre Blanchard et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pharmacodynamics of Memantine: An Update

(2008) C. Parsons et al.   Current Neuropharmacology

Memantine does not show intracellular block of the NMDA receptor channel

(2008) Chris G. Parsons et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Blocking kinetics of memantine on NR1a/2A receptors recorded in inside-out and outside-out patches from Xenopus oocytes

(2008) Chris G. Parsons et al.   JOURNAL OF NEURAL TRANSMISSION

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Cognition-enhancing and anxiolytic effects of memantine

(2008) Rimante Minkeviciene et al.   NEUROPHARMACOLOGY

A systematic review of off-label uses of memantine for psychiatric disorders

(2008) Kristina Zdanys et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Improvement in behavioural symptoms in patients with moderate to severe Alzheimer's disease by memantine: a pooled data analysis

(2007) S. Gauthier et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Mg2+and memantine block of rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed inXenopus laevisoocytes

(2007) David C. Wrighton et al.   JOURNAL OF PHYSIOLOGY-LONDON