Hallmark discoveries in the biology of Wilms tumour

Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution

(2023) Bahar Rastegar et al.   CLINICAL CANCER RESEARCH

Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only − the SIOP 93–01 and 2001 protocols

(2022) Alissa Groenendijk et al.   EUROPEAN JOURNAL OF CANCER

Circulating Tumor DNA as a Biomarker in Patients With Stage III and IV Wilms Tumor: Analysis From a Children's Oncology Group Trial, AREN0533

(2022) Laura M. Madanat-Harjuoja et al.   JOURNAL OF CLINICAL ONCOLOGY

Progress by international collaboration for pediatric renal tumors by HARMONIzation and COllaboration: The HARMONICA initiative

(2022) M. M. van den Heuvel‐Eibrink et al.   PEDIATRIC BLOOD & CANCER

Fifty years of clinical and research studies for childhood renal tumors within the International Society of Pediatric Oncology (SIOP)

(2021) N. Graf et al.   ANNALS OF ONCOLOGY

Wilms tumour surveillance in at-risk children: Literature review and recommendations from the SIOP-Europe Host Genome Working Group and SIOP Renal Tumour Study Group

(2021) Janna A. Hol et al.   EUROPEAN JOURNAL OF CANCER

Prognostic Factors for Wilms Tumor Recurrence: A Review of the Literature

(2021) Alissa Groenendijk et al.   Cancers

Extensive clonal branching shapes the evolutionary history of high-risk pediatric cancers

(2020) Natalie Andersson et al.   CANCER RESEARCH

11p15.5 epimutations in children with Wilms tumor and hepatoblastoma detected in peripheral blood

(2020) Elise M. Fiala et al.   CANCER

Outcome analysis of stage I epithelial‐predominant favorable‐histology Wilms tumors: A report from Children's Oncology Group study AREN03B2

(2020) Lauren N. Parsons et al.   CANCER

An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

(2020) Camilla Calandrini et al.   Nature Communications

Assessment of somatic mutations in urine and plasma of Wilms tumor patients

(2020) Ana Carolina Kerekes Miguez et al.   Cancer Medicine

Characteristics and Outcome of Children with Renal Cell Carcinoma: A Narrative Review

(2020) Justine N. van der Beek et al.   Cancers

Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses

(2020) Jack Brzezinski et al.   BRITISH JOURNAL OF CANCER

Analysis of the mutational status of SIX1/2 and microRNA processing genes in paired primary and relapsed Wilms tumors and association with relapse

(2020) Sara Ciceri et al.   CANCER GENE THERAPY

New approaches to risk stratification for Wilms tumor

(2020) Marie V. Nelson et al.   CURRENT OPINION IN PEDIATRICS

Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations

(2020) Brigitte Royer-Pokora et al.   Cancers

Unmet needs for relapsed or refractory Wilms tumour: Mapping the molecular features, exploring organoids and designing early phase trials – A collaborative SIOP-RTSG, COG and ITCC session at the first SIOPE meeting

(2020) Jesper Brok et al.   EUROPEAN JOURNAL OF CANCER

Tubuloids derived from human adult kidney and urine for personalized disease modeling

(2019) Frans Schutgens et al.   NATURE BIOTECHNOLOGY

TRIM28 haploinsufficiency predisposes to Wilms tumor

(2019) Illja J. Diets et al.   INTERNATIONAL JOURNAL OF CANCER

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Characterization of the Beckwith‐Wiedemann spectrum: Diagnosis and management

(2019) Kelly A. Duffy et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Augmentation of Therapy for Combined Loss of Heterozygosity 1p and 16q in Favorable Histology Wilms Tumor: A Children’s Oncology Group AREN0532 and AREN0533 Study Report

(2019) David B. Dix et al.   JOURNAL OF CLINICAL ONCOLOGY

High-risk blastemal Wilms tumor can be modeled by 3D spheroid cultures in vitro

(2019) Jenny Wegert et al.   ONCOGENE

Genes Controlled by DNA Methylation Are Involved in Wilms Tumor Progression

(2019) João Victor da Silva Guerra et al.   Cells

A rectal cancer organoid platform to study individual responses to chemoradiation

(2019) Karuna Ganesh et al.   NATURE MEDICINE

Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients

(2019) Salo N. Ooft et al.   Science Translational Medicine

Impaired cell fate through gain-of-function mutations in a chromatin reader

(2019) Liling Wan et al.   NATURE

Embryonal precursors of Wilms tumor

(2019) Tim H. H. Coorens et al.   SCIENCE

Forty-five patient-derived xenografts capture the clinical and biological heterogeneity of Wilms tumor

(2019) Andrew J. Murphy et al.   Nature Communications

A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

(2018) Norman Sachs et al.   CELL

DICER1and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies

(2018) Kris Ann P. Schultz et al.   CLINICAL CANCER RESEARCH

Identification of a novel CTR9 germline mutation in a family with Wilms tumor

(2018) António G. Martins et al.   European Journal of Medical Genetics

Urine cell-free DNA is a biomarker for nephroblastomatosis or Wilms tumor in PIK3CA-related overgrowth spectrum (PROS)

(2018) Marta Biderman Waberski et al.   GENETICS IN MEDICINE

Outcome and Prognostic Factors in Stage III Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group Study AREN0532

(2018) Conrad V. Fernandez et al.   JOURNAL OF CLINICAL ONCOLOGY

Four evolutionary trajectories underlie genetic intratumoral variation in childhood cancer

(2018) Jenny Karlsson et al.   NATURE GENETICS

Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith–Wiedemann syndrome: an international consensus statement

(2018) Frédéric Brioude et al.   Nature Reviews Endocrinology

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

(2018) Georgios Vlachogiannis et al.   SCIENCE

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

(2018) Hervé Tiriac et al.   Cancer Discovery

Germline mutations and somatic inactivation of TRIM28 in Wilms tumour

(2018) Benjamin J. Halliday et al.   PLoS Genetics

Geometry of Gene Expression Space of Wilms' Tumors From Human Patients

(2018) Ariel Trink et al.   NEOPLASIA

Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors

(2018) Matthew D. Young et al.   SCIENCE

Somatic TP53 Mutations Are Detectable in Circulating Tumor DNA from Children with Anaplastic Wilms Tumors

(2018) Taryn D. Treger et al.   Translational Oncology

The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol

(2018) Gordan M. Vujanić et al.   Nature Reviews Urology

A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children’s Oncology Group study

(2018) Amy E. Armstrong et al.   PLoS One

Wilms tumour in Beckwith–Wiedemann Syndrome and loss of methylation at imprinting centre 2: revisiting tumour surveillance guidelines

(2017) Jack Brzezinski et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy

(2017) Xuetian Yue et al.   JOURNAL OF MOLECULAR BIOLOGY

Orthotopic patient-derived xenografts of paediatric solid tumours

(2017) Elizabeth Stewart et al.   NATURE

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation

(2017) Shawn Yost et al.   NATURE GENETICS

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor

(2017) Samantha Gadd et al.   NATURE GENETICS

Human primary liver cancer–derived organoid cultures for disease modeling and drug screening

(2017) Laura Broutier et al.   NATURE MEDICINE

Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol

(2017) Marry M. van den Heuvel-Eibrink et al.   Nature Reviews Urology

Sonographic screening for Wilms tumor in children with CLOVES syndrome

(2017) Caitlin M. Peterman et al.   PEDIATRIC BLOOD & CANCER

The MYCN Protein in Health and Disease

(2017) María Victoria Ruiz-Pérez et al.   Genes

Phenotype, cancer risk, and surveillance in Beckwith-Wiedemann syndrome depending on molecular genetic subgroups

(2016) Saskia M. Maas et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Wilms tumor and trisomy 18: Is there an association?

(2016) John C. Carey et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group

(2016) Ariadne H.A.G. Ooms et al.   CLINICAL CANCER RESEARCH

TP53Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data

(2016) Liacine Bouaoun et al.   HUMAN MUTATION

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study

(2016) Tasnim Chagtai et al.   JOURNAL OF CLINICAL ONCOLOGY

Association of Chromosome 1q Gain With Inferior Survival in Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group

(2016) Eric J. Gratias et al.   JOURNAL OF CLINICAL ONCOLOGY

Anaplastic histology Wilms’ tumors registered to the Japan Wilms’ Tumor Study Group are less aggressive than that in the National Wilms’ Tumor Study 5

(2016) Takaharu Oue et al.   PEDIATRIC SURGERY INTERNATIONAL

Chromosomal anomalies at 1q, 3, 16q, and mutations of SIX1 and DROSHA genes underlie Wilms tumor recurrences

(2016) Filippo Spreafico et al.   Oncotarget

Dissecting Stages of Human Kidney Development and Tumorigenesis with Surface Markers Affords Simple Prospective Purification of Nephron Stem Cells

(2016) Naomi Pode-Shakked et al.   Scientific Reports

Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation

(2016) Le Huang et al.   NEOPLASIA

Intra-Tumor Genetic Heterogeneity in Wilms Tumor: Clonal Evolution and Clinical Implications

(2016) George D. Cresswell et al.   EBioMedicine

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Clinical and Molecular Characterization of Patients with Heterozygous Mutations in Wilms Tumor Suppressor Gene 1

(2015) A. Lehnhardt et al.   Clinical Journal of the American Society of Nephrology

Outcome of localised blastemal-type Wilms tumour patients treated according to intensified treatment in the SIOP WT 2001 protocol, a report of the SIOP Renal Tumour Study Group (SIOP-RTSG)

(2015) M.M. van den Heuvel-Eibrink et al.   EUROPEAN JOURNAL OF CANCER

(Epi)genotype–phenotype correlations in Beckwith–Wiedemann syndrome

(2015) Alessandro Mussa et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration

(2015) Jeffrey S. Dome et al.   JOURNAL OF CLINICAL ONCOLOGY

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

Mutations in the transcriptional repressor REST predispose to Wilms tumor

(2015) Shazia S Mahamdallie et al.   NATURE GENETICS

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

(2015) Adam Shlien et al.   NATURE GENETICS

Circulating serum miRNAs as potential biomarkers for nephroblastoma

(2015) Nicole Ludwig et al.   PEDIATRIC BLOOD & CANCER

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours

(2015) Elizabeth J. Perlman et al.   Nature Communications

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

(2015) Linda Holmquist Mengelbier et al.   Nature Communications

Multiple mechanisms of MYCN dysregulation in Wilms tumour

(2015) Richard D. Williams et al.   Oncotarget

TCF21 hypermethylation in genetically quiescent clear cell sarcoma of the kidney

(2015) Saskia L. Gooskens et al.   Oncotarget

Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour

(2015) Jocelyn Charlton et al.   Genome Medicine

Stratification of Wilms tumor by genetic and epigenetic analysis

(2015) Richard H. Scott et al.   Oncotarget

Clinically Relevant Subsets Identified by Gene Expression Patterns Support a Revised Ontogenic Model of Wilms Tumor: A Children's Oncology Group Study

(2015) Samantha Gadd et al.   NEOPLASIA

Solid Tumors of Childhood Display Specific Serum microRNA Profiles

(2014) M. J. Murray et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Organoid cultures for the analysis of cancer phenotypes

(2014) Norman Sachs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Lin28 sustains early renal progenitors and induces Wilms tumor

(2014) A. Urbach et al.   GENES & DEVELOPMENT

Genotype–phenotype associations in WT1 glomerulopathy

(2014) Beata S. Lipska et al.   KIDNEY INTERNATIONAL

The role of genomic imprinting in biology and disease: an expanding view

(2014) Jo Peters   NATURE REVIEWS GENETICS

TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia

(2014) Mariana Maschietto et al.   PLoS One

SIX2 Effects on Wilms Tumor Biology

(2014) Janene Pierce et al.   Translational Oncology

Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour

(2014) Sandra Hanks et al.   Nature Communications

Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

(2014) Dinesh Rakheja et al.   Nature Communications

Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

(2014) Giovana T. Torrezan et al.   Nature Communications

Multiple tumor types including leiomyoma and Wilms tumor in a patient with Gorlin syndrome due to 9q22.3 microdeletion encompassing the PTCH1 and FANC-C loci

(2013) Livia Garavelli et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Narrowing of the responsible region for severe developmental delay and autistic behaviors in WAGR syndrome down to 1.6 Mb includingPAX6,WT1, andPRRG4

(2013) Toshiyuki Yamamoto et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

miRConnect 2.0: identification of oncogenic, antagonistic miRNA families in three human cancers

(2013) Youjia Hua et al.   BMC GENOMICS

Gain of 1q is associated with inferior event-free and overall survival in patients with favorable histology Wilms tumor: A report from the Children's Oncology Group

(2013) Eric J. Gratias et al.   CANCER

Gain of 1q is a marker of poor prognosis in Wilms' tumors

(2013) H. Segers et al.   GENES CHROMOSOMES & CANCER

Beckwith-Wiedemann Syndrome: Growth Pattern and Tumor Risk according to Molecular Mechanism, and Guidelines for Tumor Surveillance

(2013) F. Brioude et al.   Hormone Research in Paediatrics

BiallelicDICER1mutations occur in Wilms tumours

(2013) MK Wu et al.   JOURNAL OF PATHOLOGY

Is Wilms Tumor a Candidate Neoplasia for Treatment with WNT/ -Catenin Pathway Modulators?--A Report from the Renal Tumors Biology-Driven Drug Development Workshop

(2013) D. Perotti et al.   MOLECULAR CANCER THERAPEUTICS

Incidence and outcomes of patients with late recurrence of Wilms' tumor

(2013) M. Malogolowkin et al.   PEDIATRIC BLOOD & CANCER

Phase 2 trial of cixutumumab in children, adolescents, and young adults with refractory solid tumors: A report from the Children's Oncology Group

(2013) Brenda Weigel et al.   PEDIATRIC BLOOD & CANCER

miRNA Profiles as a Predictor of Chemoresponsiveness in Wilms’ Tumor Blastema

(2013) Jenny A. Watson et al.   PLoS One

Treatment-independent miRNA signature in blood of wilms tumor patients

(2012) Jana Schmitt et al.   BMC GENOMICS

Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children

(2012) Masayuki Haruta et al.   CANCER SCIENCE

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks

(2012) Joo-Seop Park et al.   DEVELOPMENTAL CELL

The isolation and characterization of renal cancer initiating cells from human Wilms' tumour xenografts unveils new therapeutic targets

(2012) Naomi Pode-Shakked et al.   EMBO Molecular Medicine

Genomic profiling by whole-genome single nucleotide polymorphism arrays in Wilms tumor and association with relapse

(2012) Daniela Perotti et al.   GENES CHROMOSOMES & CANCER

p53 Immunohistochemistry Expression in Wilms Tumor: A Prognostic Tool in the Detection of Tumor Aggressiveness

(2012) Jan Franken et al.   JOURNAL OF UROLOGY

Loss of Heterozygosity Analysis at Different Chromosome Regions in Wilms Tumor Confirms 1p Allelic Loss as a Marker of Worse Prognosis: A Study from the Italian Association of Pediatric Hematology and Oncology

(2012) Filippo Spreafico et al.   JOURNAL OF UROLOGY

Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility

(2012) Dewi Astuti et al.   NATURE GENETICS

Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition

(2012) A. Bielen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling in Cancer

(2012) P. Polakis   Cold Spring Harbor Perspectives in Biology

Characterization of 17.94, a novel anaplastic Wilms' tumor cell line

(2012) Keith W. Brown et al.   Cancer Genetics

β-Catenin and K-RAS Synergize to Form Primitive Renal Epithelial Tumors with Features of Epithelial Wilms' Tumors

(2011) Peter E. Clark et al.   AMERICAN JOURNAL OF PATHOLOGY

The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification

(2011) Annie Moisan et al.   DEVELOPMENTAL CELL

A Wt1-Controlled Chromatin Switching Mechanism Underpins Tissue-Specific Wnt4 Activation and Repression

(2011) Abdelkader Essafi et al.   DEVELOPMENTAL CELL

Management of adults with Wilms’ tumor: recommendations based on international consensus

(2011) Heidi Segers et al.   Expert Review of Anticancer Therapy

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Characterization of primary wilms tumor cultures as an in vitro model

(2011) Jenny Wegert et al.   GENES CHROMOSOMES & CANCER

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in wilms tumor

(2011) Richard D. Williams et al.   GENES CHROMOSOMES & CANCER

Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor

(2010) R. D. Williams et al.   CLINICAL CANCER RESEARCH

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation

(2010) Qianghua Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

WT1 Mutation and 11P15 Loss of Heterozygosity Predict Relapse in Very Low-Risk Wilms Tumors Treated With Surgery Alone: A Children's Oncology Group Study

(2010) Elizabeth J. Perlman et al.   JOURNAL OF CLINICAL ONCOLOGY

Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney

(2010) Vidya K. Nagalakshmi et al.   KIDNEY INTERNATIONAL

Initial testing of a monoclonal antibody (IMC-A12) against IGF-1R by the pediatric preclinical testing program

(2010) Peter J. Houghton et al.   PEDIATRIC BLOOD & CANCER

Predicting Relapse in Favorable Histology Wilms Tumor Using Gene Expression Analysis: A Report from the Renal Tumor Committee of the Children's Oncology Group

(2009) C.-C. Huang et al.   CLINICAL CANCER RESEARCH

Subsets of Very Low Risk Wilms Tumor Show Distinctive Gene Expression, Histologic, and Clinical Features

(2009) S. T. Sredni et al.   CLINICAL CANCER RESEARCH

Allele loss at 16q defines poorer prognosis Wilms tumour irrespective of treatment approach in the UKW1–3 clinical trials: A Children’s Cancer and Leukaemia Group (CCLG) study

(2009) Boo Messahel et al.   EUROPEAN JOURNAL OF CANCER

Beckwith–Wiedemann syndrome

(2009) Rosanna Weksberg et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

WTXinactivation is a frequent, but late event in Wilms tumors without apparent clinical impact

(2009) Jenny Wegert et al.   GENES CHROMOSOMES & CANCER

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and theMYCandMYCNLoci

(2009) Stefan Pfister et al.   JOURNAL OF CLINICAL ONCOLOGY

The pathology of Wilms' tumour (nephroblastoma): the International Society of Paediatric Oncology approach

(2009) G. M. Vujanic et al.   JOURNAL OF CLINICAL PATHOLOGY

Canonical WNT signalling determines lineage specificity in Wilms tumour

(2009) R Fukuzawa et al.   ONCOGENE

Perlman syndrome: Report, prenatal findings and review

(2008) Jean-Luc Alessandri et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: Delineation of clinical subtypes

(2008) Herbert García‐Castillo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Molecular cytogenetic anomalies and phenotype alterations in a newly established cell line from Wilms tumor with diffuse anaplasia

(2008) Marine Faussillon et al.   CANCER GENETICS AND CYTOGENETICS

The E2F3-Oncomir-1 Axis Is Activated in Wilms' Tumor

(2008) E. J. Kort et al.   CANCER RESEARCH

Perilobar Nephrogenic Rests Are Nonobligate Molecular Genetic Precursor Lesions of Insulin-Like Growth Factor-II-Associated Wilms Tumors

(2008) R. Vuononvirta et al.   CLINICAL CANCER RESEARCH

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors

(2008) Stefanie Wittmann et al.   GENES CHROMOSOMES & CANCER

Wilms tumor genetics: Mutations inWT1,WTX, andCTNNB1 account for only about one-third of tumors

(2008) E. Cristy Ruteshouser et al.   GENES CHROMOSOMES & CANCER

Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour

(2008) F. Cerrato et al.   HUMAN MOLECULAR GENETICS

Developmental tumourigenesis: NCAM as a putative marker for the malignant renal stem/progenitor cell population

(2008) Naomi Pode-Shakked et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Epigenotype, Phenotype, and Tumors in Patients with Isolated Hemihyperplasia

(2008) Jet Bliek et al.   JOURNAL OF PEDIATRICS

Constitutional 11p15 abnormalities, including heritable imprinting center mutations, cause nonsyndromic Wilms tumor

(2008) Richard H Scott et al.   NATURE GENETICS

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis

(2008) Zandra A Jenkins et al.   NATURE GENETICS

Functional inactivation of the WTX gene is not a frequent event in Wilms’ tumors

(2008) D Perotti et al.   ONCOGENE

Circulating microRNAs as stable blood-based markers for cancer detection

(2008) P. S. Mitchell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accumulation of Malignant Renal Stem Cells Is Associated with Epigenetic Changes in Normal Renal Progenitor Genes

(2008) Sally Metsuyanim et al.   STEM CELLS

Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: A collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups

(2007) Marry M. van den Heuvel-Eibrink et al.   PEDIATRIC BLOOD & CANCER