Clinically and biologically relevant subgroups of Wilms tumour defined by genomic and epigenomic analyses

De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency

(2019) Masaki Yagi et al.   Stem Cell Reports

Embryonal precursors of Wilms tumor

(2019) Tim H. H. Coorens et al.   SCIENCE

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Germline mutations and somatic inactivation of TRIM28 in Wilms tumour

(2018) Benjamin J. Halliday et al.   PLoS Genetics

Outcome of two patients with bilateral nephroblastomatosis/Wilms tumour treated with an add-on 13-cis retinoic acid therapy – Case report

(2018) Waltraud Friesenbichler et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Insights into imprinting from parent-of-origin phased methylomes and transcriptomes

(2018) Florian Zink et al.   NATURE GENETICS

A unique subset of low-risk Wilms tumors is characterized by loss of function of TRIM28 (KAP1), a gene critical in early renal development: A Children’s Oncology Group study

(2018) Amy E. Armstrong et al.   PLoS One

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor

(2017) Samantha Gadd et al.   NATURE GENETICS

Significance of TP53 Mutation in Wilms Tumors with Diffuse Anaplasia: A Report from the Children's Oncology Group

(2016) Ariadne H.A.G. Ooms et al.   CLINICAL CANCER RESEARCH

Gain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study

(2016) Tasnim Chagtai et al.   JOURNAL OF CLINICAL ONCOLOGY

Association of Chromosome 1q Gain With Inferior Survival in Favorable-Histology Wilms Tumor: A Report From the Children’s Oncology Group

(2016) Eric J. Gratias et al.   JOURNAL OF CLINICAL ONCOLOGY

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Profiling placental and fetal DNA methylation in human neural tube defects

(2016) E. Magda Price et al.   Epigenetics & Chromatin

Recurrent DGCR8, DROSHA, and SIX Homeodomain Mutations in Favorable Histology Wilms Tumors

(2015) Amy L. Walz et al.   CANCER CELL

Mutations in the SIX1/2 Pathway and the DROSHA/DGCR8 miRNA Microprocessor Complex Underlie High-Risk Blastemal Type Wilms Tumors

(2015) Jenny Wegert et al.   CANCER CELL

Advances in Wilms Tumor Treatment and Biology: Progress Through International Collaboration

(2015) Jeffrey S. Dome et al.   JOURNAL OF CLINICAL ONCOLOGY

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

ClinVar: public archive of interpretations of clinically relevant variants

(2015) Melissa J. Landrum et al.   NUCLEIC ACIDS RESEARCH

Somatic mosaicism: implications for disease and transmission genetics

(2015) Ian M. Campbell et al.   TRENDS IN GENETICS

Comparative methylome analysis identifies new tumour subtypes and biomarkers for transformation of nephrogenic rests into Wilms tumour

(2015) Jocelyn Charlton et al.   Genome Medicine

Stratification of Wilms tumor by genetic and epigenetic analysis

(2015) Richard H. Scott et al.   Oncotarget

Clinically Relevant Subsets Identified by Gene Expression Patterns Support a Revised Ontogenic Model of Wilms Tumor: A Children's Oncology Group Study

(2015) Samantha Gadd et al.   NEOPLASIA

Mutations inSETD2cause a novel overgrowth condition

(2014) Armelle Luscan et al.   JOURNAL OF MEDICAL GENETICS

A general framework for estimating the relative pathogenicity of human genetic variants

(2014) Martin Kircher et al.   NATURE GENETICS

MutationTaster2: mutation prediction for the deep-sequencing age

(2014) Jana Marie Schwarz et al.   NATURE METHODS

Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies

(2012) Andrew E Jaffe et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Imprinting of RB1 (the new kid on the block)

(2011) K. Buiting et al.   Briefings in Functional Genomics

A novel approach identifies new differentially methylated regions (DMRs) associated with imprinted genes

(2011) S. Choufani et al.   GENOME RESEARCH

Retinoic acid pathway activity in wilms tumors and characterization of biological responses in vitro

(2011) Jenny Wegert et al.   Molecular Cancer

Predicting the functional impact of protein mutations: application to cancer genomics

(2011) Boris Reva et al.   NUCLEIC ACIDS RESEARCH

Wt1 ablation and Igf2 upregulation in mice result in Wilms tumors with elevated ERK1/2 phosphorylation

(2010) Qianghua Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

GREAT improves functional interpretation of cis-regulatory regions

(2010) Cory Y McLean et al.   NATURE BIOTECHNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Interplay between activin and Hox genes determines the formation of the kidney morphogenetic field

(2009) E. Preger-Ben Noon et al.   DEVELOPMENT

Beckwith–Wiedemann syndrome

(2009) Rosanna Weksberg et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Accumulation of Malignant Renal Stem Cells Is Associated with Epigenetic Changes in Normal Renal Progenitor Genes

(2008) Sally Metsuyanim et al.   STEM CELLS