Somatic mutations in DROSHA and DICER1 impair microRNA biogenesis through distinct mechanisms in Wilms tumours

Biallelic DICER1 Mutations in Sporadic Pleuropulmonary Blastoma

(2014) M. Seki et al.   CANCER RESEARCH

Lin28 sustains early renal progenitors and induces Wilms tumor

(2014) A. Urbach et al.   GENES & DEVELOPMENT

Expanding the phenotype of mutations in DICER1: mosaic missense mutations in the RNase IIIb domain ofDICER1cause GLOW syndrome

(2014) Steven Klein et al.   JOURNAL OF MEDICAL GENETICS

Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour

(2014) Giovana T. Torrezan et al.   Nature Communications

BiallelicDICER1mutations occur in Wilms tumours

(2013) MK Wu et al.   JOURNAL OF PATHOLOGY

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers

(2012) Ryan S. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

GermlineDICER1mutation and associated loss of heterozygosity in a pineoblastoma: Figure 1

(2012) Nelly Sabbaghian et al.   JOURNAL OF MEDICAL GENETICS

Cancer-associated somaticDICER1hotspot mutations cause defective miRNA processing and reverse-strand expression bias to predominantly mature 3p strands through loss of 5p strand cleavage

(2012) MS Anglesio et al.   JOURNAL OF PATHOLOGY

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Site-specific DICER and DROSHA RNA products control the DNA-damage response

(2012) Sofia Francia et al.   NATURE

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression

(2012) Jan J Molenaar et al.   NATURE GENETICS

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

(2012) Mark Sausen et al.   NATURE GENETICS

In vivo structure-function analysis of human Dicer reveals directional processing of precursor miRNAs

(2012) A. M. Gurtan et al.   RNA

Nonsense Mutation and Inactivation of SMARCA4 (BRG1) in an Atypical Teratoid/Rhabdoid Tumor Showing Retained SMARCB1 (INI1) Expression

(2011) Martin Hasselblatt et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Molecular profiling reveals frequent gain of MYCN and anaplasia-specific loss of 4q and 14q in wilms tumor

(2011) Richard D. Williams et al.   GENES CHROMOSOMES & CANCER

Extending the phenotypes associated withDICER1mutations

(2011) William D. Foulkes et al.   HUMAN MUTATION

DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome

(2011) I. Slade et al.   JOURNAL OF MEDICAL GENETICS

Targeted gene disruption in somatic zebrafish cells using engineered TALENs

(2011) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

Recurrent SomaticDICER1Mutations in Nonepithelial Ovarian Cancers

(2011) Alireza Heravi-Moussavi et al.   NEW ENGLAND JOURNAL OF MEDICINE

miRNA Processing and Human Cancer: DICER1 Cuts the Mustard

(2011) A. Bahubeshi et al.   Science Translational Medicine

Subtype-Specific FBXW7 Mutation and MYCN Copy Number Gain in Wilms' Tumor

(2010) R. D. Williams et al.   CLINICAL CANCER RESEARCH

Late Toxicity in Wilms Tumor Patients Treated With Radiotherapy at 15 Years of Median Follow-up

(2010) Giuseppe Sasso et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

(2010) J. D. Sander et al.   NUCLEIC ACIDS RESEARCH

Wilms' tumour: a systematic review of risk factors and meta-analysis

(2010) Anna Chu et al.   PAEDIATRIC AND PERINATAL EPIDEMIOLOGY

Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo

(2009) I Lambertz et al.   CELL DEATH AND DIFFERENTIATION

Dicer1 functions as a haploinsufficient tumor suppressor

(2009) M. S. Kumar et al.   GENES & DEVELOPMENT

Lin28 promotes transformation and is associated with advanced human malignancies

(2009) Srinivas R Viswanathan et al.   NATURE GENETICS

LATE EFFECTS OF TREATMENT FOR WILMS TUMOR

(2009) Karen D. Wright et al.   PEDIATRIC HEMATOLOGY AND ONCOLOGY

Lin-28B transactivation is necessary for Myc-mediated let-7 repression and proliferation

(2009) T.-C. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DICER1 Mutations in Familial Pleuropulmonary Blastoma

(2009) D. A. Hill et al.   SCIENCE

Wilms tumor genetics: Mutations inWT1,WTX, andCTNNB1 account for only about one-third of tumors

(2008) E. Cristy Ruteshouser et al.   GENES CHROMOSOMES & CANCER

let-7 microRNAs in development, stem cells and cancer

(2008) Ingo Büssing et al.   TRENDS IN MOLECULAR MEDICINE

Current management of Wilms’ tumor in children

(2008) Edmund Y. Ko et al.   Journal of Pediatric Urology