Self-patterning of human stem cells into post-implantation lineages

Decoding anterior-posterior axis emergence among mouse, monkey, and human embryos

(2023) Qingyuan Zhu et al.   DEVELOPMENTAL CELL

Amniogenesis occurs in two independent waves in primates

(2022) Maria Rostovskaya et al.   Cell Stem Cell

Cross-tissue immune cell analysis reveals tissue-specific features in humans

(2022) C. Domínguez Conde et al.   SCIENCE

Periodic formation of epithelial somites from human pluripotent stem cells

(2022) Marina Sanaki-Matsumiya et al.   Nature Communications

Microgel culture and spatial identity mapping elucidate the signalling requirements for primate epiblast and amnion formation

(2022) Clara Munger et al.   DEVELOPMENT

Spatial profiling of early primate gastrulation in utero

(2022) Sophie Bergmann et al.   NATURE

Reconstruction and deconstruction of human somitogenesis in vitro

(2022) Yuchuan Miao et al.   NATURE

Reconstituting human somitogenesis in vitro

(2022) Yoshihiro Yamanaka et al.   NATURE

Human naive epiblast cells possess unrestricted lineage potential

(2021) Ge Guo et al.   Cell Stem Cell

Naive stem cell blastocyst model captures human embryo lineage segregation

(2021) Ayaka Yanagida et al.   Cell Stem Cell

Modelling human blastocysts by reprogramming fibroblasts into iBlastoids

(2021) Xiaodong Liu et al.   NATURE

Blastocyst-like structures generated from human pluripotent stem cells

(2021) Leqian Yu et al.   NATURE

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre

(2021) Matteo A. Molè et al.   Nature Communications

Reconstructing aspects of human embryogenesis with pluripotent stem cells

(2021) Berna Sozen et al.   Nature Communications

Human neural tube morphogenesis in vitro by geometric constraints

(2021) Eyal Karzbrun et al.   NATURE

Human blastoids model blastocyst development and implantation

(2021) Harunobu Kagawa et al.   NATURE

Single-cell transcriptomic characterization of a gastrulating human embryo

(2021) Richard C. V. Tyser et al.   NATURE

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

A wave of WNT signaling balanced by secreted inhibitors controls primitive streak formation in micropattern colonies of human embryonic stem cells

(2019) Iain Martyn et al.   DEVELOPMENT

Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation

(2019) Maria Rostovskaya et al.   DEVELOPMENT

The emergent landscape of the mouse gut endoderm at single-cell resolution

(2019) Sonja Nowotschin et al.   NATURE

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

(2019) Mijo Simunovic et al.   NATURE CELL BIOLOGY

Reconstituting the transcriptome and DNA methylome landscapes of human implantation

(2019) Fan Zhou et al.   NATURE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

(2019) Madeleine Linneberg-Agerholm et al.   DEVELOPMENT

In vitro culture of cynomolgus monkey embryos beyond early gastrulation

(2019) Huaixiao Ma et al.   SCIENCE

Self-Organization of Mouse Stem Cells into an Extended Potential Blastoid

(2019) Berna Sozen et al.   DEVELOPMENTAL CELL

A developmental landscape of 3D-cultured human pre-gastrulation embryos

(2019) Lifeng Xiang et al.   NATURE

Orchestrating single-cell analysis with Bioconductor

(2019) Robert A. Amezquita et al.   NATURE METHODS

Wnt Inhibition Facilitates RNA-Mediated Reprogramming of Human Somatic Cells to Naive Pluripotency

(2019) Nicholas Bredenkamp et al.   Stem Cell Reports

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Derivation of Human Trophoblast Stem Cells

(2018) Hiroaki Okae et al.   Cell Stem Cell

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids

(2018) Anna Yoney et al.   eLife

Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer

(2017) Zachary D. Smith et al.   NATURE

Principles of early human development and germ cell program from conserved model systems

(2017) Toshihiro Kobayashi et al.   NATURE

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

The Germ Cell Fate of Cynomolgus Monkeys Is Specified in the Nascent Amnion

(2016) Kotaro Sasaki et al.   DEVELOPMENTAL CELL

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Early Developmental and Evolutionary Origins of Gene Body DNA Methylation Patterns in Mammalian Placentas

(2015) Diane I. Schroeder et al.   PLoS Genetics

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Derivation of novel human ground state naive pluripotent stem cells

(2013) Ohad Gafni et al.   NATURE

The roles of FGF and MAP kinase signaling in the segregation of the epiblast and hypoblast cell lineages in bovine and human embryos

(2012) E. W. Kuijk et al.   DEVELOPMENT

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

(2012) Timothy A. Blauwkamp et al.   Nature Communications

Human hypoblast formation is not dependent on FGF signalling

(2011) Mila Roode et al.   DEVELOPMENTAL BIOLOGY

Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo

(2011) Katsuyoshi Takaoka et al.   NATURE CELL BIOLOGY

Activin/Nodal Signaling Controls Divergent Transcriptional Networks in Human Embryonic Stem Cells and in Endoderm Progenitors

(2011) Stephanie Brown et al.   STEM CELLS

Developmental Stages in Human Embryos: Revised and New Measurements

(2010) Ronan O’Rahilly et al.   CELLS TISSUES ORGANS

The Endoderm of the Mouse Embryo Arises by Dynamic Widespread Intercalation of Embryonic and Extraembryonic Lineages

(2008) Gloria S. Kwon et al.   DEVELOPMENTAL CELL