Cancer aneuploidies are shaped primarily by effects on tumour fitness

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

(2023) Gregory J. Kimmel et al.   PLoS Computational Biology

Complete genomic and epigenetic maps of human centromeres

(2022) Nicolas Altemose et al.   SCIENCE

The complete sequence of a human genome

(2022) Sergey Nurk et al.   SCIENCE

Nuclear chromosome locations dictate segregation error frequencies

(2022) Sjoerd J. Klaasen et al.   NATURE

Tangent normalization for somatic copy-number inference in cancer genome analysis

(2022) Galen F Gao et al.   BIOINFORMATICS

Clonal fitness inferred from time-series modelling of single-cell cancer genomes

(2021) Sohrab Salehi et al.   NATURE

Pan-cancer analysis of whole genomes

(2020)   NATURE

Patterns of somatic structural variation in human cancer genomes

(2020) Yilong Li et al.   NATURE

Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution

(2020) Saioa López et al.   NATURE GENETICS

How Cells Respond to DNA Breaks in Mitosis

(2020) Andrew N. Blackford et al.   TRENDS IN BIOCHEMICAL SCIENCES

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

(2020) Caitlin A. Nichols et al.   Nature Communications

WRN helicase is a synthetic lethal target in microsatellite unstable cancers

(2019) Edmond M. Chan et al.   NATURE

Human chromosome‐specific aneuploidy is influenced by DNA ‐dependent centromeric features

(2019) Marie Dumont et al.   EMBO JOURNAL

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

(2018) Alison M. Taylor et al.   CANCER CELL

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Higher-Order Inter-chromosomal Hubs Shape 3D Genome Organization in the Nucleus

(2018) Sofia A. Quinodoz et al.   CELL

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

(2018) Katherine A. Hoadley et al.   CELL

Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

(2018) Theo A. Knijnenburg et al.   Cell Reports

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

(2018) Qingsong Gao et al.   Cell Reports

Genetic interactions between specific chromosome copy number alterations dictate complex aneuploidy patterns

(2018) Madhwesh C. Ravichandran et al.   GENES & DEVELOPMENT

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

(2018) James M. McFarland et al.   Nature Communications

The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

(2018) V. Barra et al.   Nature Communications

Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors

(2018) Sadegh Saghafinia et al.   Cell Reports

Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

(2017) Yansheng Liu et al.   Nature Communications

Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors

(2017) Viktor A. Adalsteinsson et al.   Nature Communications

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells

(2017) Narumi Uno et al.   Scientific Reports

Loss of Chromosome 8p Governs Tumor Progression and Drug Response by Altering Lipid Metabolism

(2016) Yanyan Cai et al.   CANCER CELL

Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors

(2016) Jaegil Kim et al.   NATURE GENETICS

Selectivity of ORC binding sites and the relation to replication timing, fragile sites, and deletions in cancers

(2016) Benoit Miotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective advantage of trisomic human cells cultured in non-standard conditions

(2016) Samuel D. Rutledge et al.   Scientific Reports

regioneR: an R/Bioconductor package for the association analysis of genomic regions based on permutation tests

(2015) Bernat Gel et al.   BIOINFORMATICS

Gene Essentiality Is a Quantitative Property Linked to Cellular Evolvability

(2015) Gaowen Liu et al.   CELL

fitdistrplus: AnRPackage for Fitting Distributions

(2015) Marie Laure Delignette-Muller et al.   Journal of Statistical Software

Pericentromeric satellite repeat expansions through RNA-derived DNA intermediates in cancer

(2015) Francesca Bersani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

(2015) S. Kasar et al.   Nature Communications

The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

(2015) Anna B. Sunshine et al.   PLOS BIOLOGY

Dosage compensation can buffer copy-number variation in wild yeast

(2015) James Hose et al.   eLife

Characterization of Aneuploid Populations with Trisomy 7 and 20 Derived from Diploid Human Colonic Epithelial Cells

(2015) Peter Ly et al.   NEOPLASIA

Combining calls from multiple somatic mutation-callers

(2014) Su Kim et al.   BMC BIOINFORMATICS

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

Software for Computing and Annotating Genomic Ranges

(2013) Michael Lawrence et al.   PLoS Computational Biology

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

(2012) W. Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human Telomere Length Correlates to the Size of the Associated Chromosome Arm

(2009) Jasen L. Wise et al.   PLoS One

Buffering of Segmental and Chromosomal Aneuploidies in Drosophila melanogaster

(2009) Per Stenberg et al.   PLoS Genetics

Integrated detection and population-genetic analysis of SNPs and copy number variation

(2008) Steven A McCarroll et al.   NATURE GENETICS

Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs

(2008) Joshua M Korn et al.   NATURE GENETICS

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE