Article
Chemistry, Physical
Mengbiao Guo, Zhou Songyang, Yuanyan Xiong
Summary: ChArmTelo is a computational toolbox for analyzing telomeres at the chromosome arm level in humans and other animals. It has been demonstrated to reveal population-specific differences in arm-level telomere lengths and identify liver cancer signatures. It also suggests that disruption of DNA replication origin may play a role in cancer by affecting telomere lengths.
Editorial Material
Biochemical Research Methods
Yafei Mao, Guojie Zhang
Summary: The release of the first telomere-to-telomere human genome sequence is a significant milestone in human genomics research, offering potential insights for evolutionary genomics. This article describes the advances of this new genome assembly and discusses the challenges of applying this sequencing strategy to various extant species.
Article
Multidisciplinary Sciences
Savannah J. Hoyt, Jessica M. Storer, Gabrielle A. Hartley, Patrick G. S. Grady, Ariel Gershman, Leonardo G. de Lima, Charles Limouse, Reza Halabian, Luke Wojenski, Matias Rodriguez, Nicolas Altemose, Arang Rhie, Leighton J. Core, Jennifer L. Gerton, Wojciech Makalowski, Daniel Olson, Jeb Rosen, Arian F. A. Smit, Aaron F. Straight, Mitchell R. Vollger, Travis J. Wheeler, Michael C. Schatz, Evan E. Eichler, Adam M. Phillippy, Winston Timp, Karen H. Miga, Rachel J. O'Neill
Summary: Mobile elements and repetitive genomic regions play a crucial role in lineage-specific genomic innovation and can uniquely identify individual genomes. This study presents a novel approach to de novo repeat discovery and annotation of the T2T-CHM13 human reference genome, expanding our understanding of the diversity, distribution, and evolution of repetitive regions in the human genome.
Article
Cell Biology
Despoina Sakellariou, Sara Thornby Bak, Esin Isik, Sonia Barroso, Antonio Porro, Andres Aguilera, Jiri Bartek, Pavel Janscak, Javier Pena-Diaz
Summary: The study reveals that the mismatch repair protein MutS beta is enriched at telomeres in ALT cancer cells, preventing the accumulation of G-quadruplex (G4) structures and R-loops, thus maintaining telomere integrity during alternative lengthening of telomeres.
Article
Cell Biology
Aenne S. von Falkenhausen, Rebecca Freudling, Melanie Waldenberger, Christian Gieger, Annette Peters, Martina Mueller-Nurasyid, Stefan Kaeaeb, Moritz F. Sinner
Summary: This study aimed to investigate the association between ECG measures and telomere length, as well as their relationship with cardiac pathologies. The results showed that while ECG measures were influenced by age, they were not associated with shortened telomere length as a marker of biological aging.
Article
Medicine, General & Internal
Dries S. Martens, Charlotte Van der Stukken, Catherine Derom, Evert Thiery, Esm Ee M. Bijnens, Tim S. Nawrot
Summary: The study found that there is a correlation between telomere length at birth and later in life in both children and adults. The ranking of telomere length tends to be stable over time, indicating the importance of understanding the initial setting of newborn telomere length and its significance for later life. Additionally, longer maternal telomere length is associated with lower telomere attrition in the next generation.
Article
Biochemistry & Molecular Biology
Xu Li, Meijie Wang, Wei Zheng, Wei Huang, Zeyu Wang, Kairang Jin, Lin Liu, Zhongbo Yu
Summary: Chromosome stability is primarily determined by telomere length, which is regulated by the core subunit TRF1 of shelterin. Research on the dynamics of TRF1 has shown its role in telomere organization, compaction, and interaction at telomeric DNA forks. Understanding these mechanisms can facilitate future studies on telomeres and the development of shelterin-targeted drugs.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Endocrinology & Metabolism
Mariela Edith Velazquez, Andrea L. Millan, Mailen Rojo, Giselle Adriana Abruzzese, Silvina Ema Cocucci, Andrea Elena Iglesias Molli, Gustavo Daniel Frechtel, Alicia Beatriz Motta, Gloria Edith Cerrone
Summary: Women with PCOS exhibited significantly longer absolute telomere length (aTL) compared to controls, which was associated with waist circumference, testosterone levels, obesity, and hyperandrogenism (HA) phenotype. Non-obese PCOS patients had the longest aTL, while HA-PCOS patients had the highest aTL. Interestingly, HA had a major effect on aTL in PCOS, with non-obese hyperandrogenic patients showing the longest telomeres and obese non-hyperandrogenic patients having the shortest telomeres.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Ana Milena Monsalve-Lancheros, Narda Cecilia Gonzalez-Rincon, Milciades Ibanez-Pinilla, Sandra Ramirez-Clavijo
Summary: Comparing the chromosome fragility ratio and relative telomere length of car painters occupationally exposed to organic solvents with a group of non-exposed individuals, this study found that exposure to organic solvents increases both telomere length and the rate of chromosomal fragility sites in the exposed group.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Environmental Sciences
Jaber Haj Ali, Ziad Abdeen, Kifaya Azmi, Tamar Berman, Kathrin Jager, Zohar Barnett-Itzhaki, Michael Walter
Summary: Exposure to environmental pesticides during pregnancy is associated with adverse health outcomes such as low birth weight and impaired neuro-development. This study found that pregnant women with high levels of certain pesticide metabolites in their urine had shorter telomeres. Living near agricultural fields and consuming organic food were also associated with shorter telomeres. Different pesticide metabolites had different effects on telomeres and birth weight.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Valentina Buemi, Odessa Schillaci, Mariangela Santorsola, Deborah Bonazza, Pamela Veneziano Broccia, Annie Zappone, Cristina Bottin, Giulia Dell'Omo, Sylvie Kengne, Stefano Cacchione, Grazia Daniela Raffa, Silvano Piazza, Fabrizio D'Adda di Fagagna, Roberta Benetti, Maurizio Cortale, Fabrizio Zanconati, Giannino Del Sal, Stefan Schoeftner
Summary: Researchers have found that the trimethylguanosine capping of the RNA component of the human telomerase complex plays an important role in directing telomere maintenance and suppressing the ALT pathway in cancer cells.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Dashiell J. Massey, Amnon Koren
Summary: This study presents the first comprehensive analysis of replication timing from telomere to telomere in the human genome using new sequencing data and genome assembly methods. The results reveal a high degree of consistency in replication timing among different genomic regions, and provide insights into the replication timing characteristics and differences of centromeric and heterochromatic regions.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Chenxue Bai, Zixiong Shen, Binxu Qiu, Songling Zhang
Summary: The study found that a genetically predicted longer LTL increases the risk of endometriosis, but endometriosis has no causal impact on LTL. The results strengthen the causal link between LTL and endometriosis, suggesting that LTL may serve as a potential biomarker for endometriosis, offering new possibilities for prevention and treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Nil Novau-Ferre, Melina Rojas, Laia Gutierrez-Tordera, Pierre Arcelin, Jaume Folch, Christopher Papandreou, Monica Bullo
Summary: This study found associations between lipoprotein subfractions and telomere length, TERT, and WRAP53 expression. Medium and small-sized HDL particles were negatively associated with telomere length, TERT, and WRAP53 expression, while large HDL particles were only negatively associated with WRAP53 expression. These results suggest the importance of considering lipoprotein profiles in assessing the risk of chronic diseases.
Article
Cell Biology
Peter M. Lansdorp
Summary: Telomerase levels in most human cells are insufficient to prevent loss of telomeric DNA with each replication cycle. The resulting Hayflick limit may have allowed lifespan to increase by suppressing early tumor development but compromising cellular responses later in life. Average telomere length in leukocytes varies considerably between individuals, with females having longer telomeres than males. This difference in telomere length already exists at birth and corresponds to reported differences in average life expectancy between the sexes. The hypothesis that embryonic telomerase levels contribute to the sex differences in telomere length and lifespan requires further investigation.
Article
Dentistry, Oral Surgery & Medicine
Jami L. Ballantine, Jenna C. Carlson, Andrea G. Ferreira Zandona, Cary Agler, Leslie P. Zeldin, Richard Gary Rozier, Michael W. Roberts, Patricia V. Basta, Jason Luo, Mikafui E. Antonio-Obese, Daniel W. McNeil, Robert J. Weyant, Richard J. Crout, Rebecca L. Slayton, Steven M. Levy, John R. Shaffer, Mary L. Marazita, Kari E. North, Kimon Divaris
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2018)
Article
Dentistry, Oral Surgery & Medicine
Rebecca L. Slayton, Olivia Urquhart, Marcelo W. B. Araujo, Margherita Fontana, Sandra Guzman-Armstrong, Marcelle M. Nascimento, Brian B. Novy, Norman Tinanoff, Robert J. Weyant, Mark S. Wolff, Douglas A. Young, Domenick T. Zero, Malavika P. Tampi, Lauren Pilcher, Laura Banfield, Alonso Carrasco-Labra
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2018)
Review
Dentistry, Oral Surgery & Medicine
O. Urquhart, M. P. Tampi, L. Pilcher, R. L. Slayton, M. W. B. Araujo, M. Fontana, S. Guzman-Armstrong, M. M. Nascimento, B. B. Novy, N. Tinanoff, R. J. Weyant, M. S. Wolff, D. A. Young, D. T. Zero, R. Brignardello-Petersen, L. Banfield, A. Parikh, G. Joshi, A. Carrasco-Labra
JOURNAL OF DENTAL RESEARCH
(2019)
Article
Dentistry, Oral Surgery & Medicine
Mengxia Chen, Casey D. Wright, Oluwabunmi Tokede, Alfa Yansane, Alexander Montasem, Elsbeth Kalenderian, Terri H. Beaty, Eleanor Feingold, John R. Shaffer, Richard J. Crout, Katherine Neiswanger, Robert J. Weyant, Mary L. Marazita, Daniel W. McNeil
COMMUNITY DENTISTRY AND ORAL EPIDEMIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Daniel W. McNeil, Cameron L. Randall, Lindsey L. Cohen, Richard J. Crout, Robert J. Weyant, Katherine Neiswanger, Mary L. Marazita
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Ariel K. Snell, Jacqueline M. Burgette, Robert J. Weyant, Richard J. Crout, Daniel W. McNeil, Betsy Foxman, Mary L. Marazita
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2019)
Article
Medicine, General & Internal
Marco A. Peres, Lorna M. D. Macpherson, Robert J. Weyant, Blanaid Daly, Renato Venturelli, Manu R. Mathur, Stefan Listl, Roger Keller Celeste, Carol C. Guarnizo-Herreno, Cristin Kearns, Habib Benzian, Paul Allison, Richard G. Watt
Article
Medicine, General & Internal
Richard G. Watt, Blanaid Daly, Paul Allison, Lorna M. D. Macpherson, Renato Venturelli, Stefan Listl, Robert J. Weyant, Manu R. Mathur, Carol C. Guarnizo-Herreno, Roger Keller Celeste, Marco A. Peres, Cristin Kearns, Habib Benzian
Article
Geriatrics & Gerontology
Eftychia Kotronia, S. Goya Wannamethee, A. Olia Papacosta, Peter H. Whincup, Lucy T. Lennon, Marjolein Visser, Robert J. Weyant, Tamara B. Harris, Sheena E. Ramsay
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2019)
Article
Dentistry, Oral Surgery & Medicine
E. Orlova, J. C. Carlson, M. K. Lee, E. Feingold, D. W. McNeil, R. J. Crout, R. J. Weyant, M. L. Marazita, J. R. Shaffer
Editorial Material
Dentistry, Oral Surgery & Medicine
Stefan Listl, Robert Weyant
JOURNAL OF PUBLIC HEALTH DENTISTRY
(2019)
Article
Dentistry, Oral Surgery & Medicine
R. G. Watt, B. Daly, P. Allison, L. M. D. Macpherson, R. Venturelli, S. Listl, R. J. Weyant, M. R. Mathur, C. C. Guarnizo-Herreno, R. K. Celest, M. A. Peres, C. Kearns, H. Benzian
JOURNAL OF DENTAL RESEARCH
(2020)
Editorial Material
Dentistry, Oral Surgery & Medicine
Robert J. Weyant, Richard G. Watt
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2020)
Article
Nutrition & Dietetics
Kevin C. Lu, Zelda T. Dahl, Robert J. Weyant, Daniel W. McNeil, Betsy Foxman, Mary L. Marazita, Jacqueline M. Burgette
Summary: This study investigated why grandparents in north central and central Appalachia give their grandchildren cariogenic foods and beverages. The findings revealed that grandparents perceive their role as a privilege, responsibility, symbol of care and affection, and have limited consideration of the detrimental impact, which motivates them to provide their grandchildren with such foods and beverages.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jacqueline M. Burgette, Deborah E. Polk, Nilesh Shah, Anchal Malik, Richard J. Grout, Daniel W. McNeil, Betsy Foxman, Robert J. Weyant, Mary L. Marazita
PEDIATRIC DENTISTRY
(2019)
