Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer’s disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure

Iminoheterocycles as γ-secretase modulators

(2010) John P. Caldwell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Purine derivatives as potent γ-secretase modulators

(2010) Alexey Rivkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

β-Amyloid Precursor Protein Mutants Respond to γ-Secretase Modulators

(2010) Richard M. Page et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of a Novel Class of γ-Secretase Modulators with PPARγ Activity

(2010) Martina Hieke et al.   JOURNAL OF MEDICINAL CHEMISTRY

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease

(2010) Maria Z. Kounnas et al.   NEURON

Amyloid beta 42 peptide (A 42)-lowering compounds directly bind to A  and interfere with amyloid precursor protein (APP) transmembrane dimerization

(2010) L. Richter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the chemical space of γ-secretase modulators

(2010) Heiko Zettl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Piperazinyl pyrimidine derivatives as potent γ-secretase modulators

(2009) Alexey Rivkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorinated piperidine acetic acids as γ-secretase modulators

(2009) Matthew G. Stanton et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Piperidine-derived γ-secretase modulators

(2009) Adrian Hall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease

(2009) BP Imbimbo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Independent Generation of Aβ42 and Aβ38 Peptide Species by γ-Secretase

(2008) Eva Czirr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate-targeting γ-secretase modulators

(2008) Thomas L. Kukar et al.   NATURE