Mechanisms of acupuncture–electroacupuncture on inflammatory pain

Imaging Study on Acupuncture Inhibiting Inflammation and Bone Destruction in Knee Osteoarthritis Induced by Monosodium Iodoacetate in Rat Model

(2022) Qian Tan et al.   Journal of Pain Research

Manual acupuncture at ST36 attenuates rheumatoid arthritis by inhibiting M1 macrophage polarization and enhancing Treg cell populations in adjuvant-induced arthritic rats

(2022) Nannan Yu et al.   Acupuncture in Medicine

Optogenetic modulation of electroacupuncture analgesia in a mouse inflammatory pain model

(2022) I-Han Hsiao et al.   Scientific Reports

Electroacupuncture Reduces Visceral Pain Via Cannabinoid CB2 Receptors in a Mouse Model of Inflammatory Bowel Disease

(2022) Hong Zhang et al.   Frontiers in Pharmacology

Fire Needling Acupuncture Suppresses Cartilage Damage by Mediating Macrophage Polarization in Mice with Knee Osteoarthritis

(2022) Jiangyan Wei et al.   Journal of Pain Research

Sciatic–Vagal Nerve Stimulation by Electroacupuncture Alleviates Inflammatory Arthritis in Lyme Disease-Susceptible C3H Mice

(2022) Lavoisier Akoolo et al.   Frontiers in Immunology

Role of spinal RIP3 in inflammatory pain and electroacupuncture-mediated analgesic effect in mice

(2022) Yidan Zhang et al.   LIFE SCIENCES

Electroacupuncture decreases inflammatory pain through a pro-resolving mechanism involving the peripheral annexin A1-formyl peptide receptor 2/ALX-opioid receptor pathway

(2021) Cintia Vieira et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII

(2021) Yixiao Gu et al.   NEURAL PLASTICITY

Parvalbumin interneuron-mediated neural disruption in an animal model of postintensive care syndrome: prevention by fluoxetine

(2021) Yong Wang et al.   Aging-US

Chemokine CXCL1 in serum mediates the antinociceptive effect of manual acupuncture at ST36

(2021) Shou-Hai Hong et al.   Acupuncture in Medicine

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain

(2021) Chaofan Wan et al.   Frontiers in Neuroscience

TNF-α, CXCL-1 and IL-1 β as activators of the opioid system involved in peripheral analgesic control in mice

(2021) Jayane Laís Dias Quintão et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Electroacupuncture improves neuronal plasticity through the A2AR/cAMP/PKA signaling pathway in SNL rats

(2021) Qiaoyun Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Acupuncture modulates extracellular ATP levels in peripheral sensory nervous system during analgesia of ankle arthritis in rats

(2021) Dan Shen et al.   Purinergic Signalling

Electroacupuncture inhibits the interaction between peripheral TRPV1 and P2X3 in rats with different pathological pain

(2021) Yingjun Liu et al.   PHYSIOLOGICAL RESEARCH

Electroacupuncture alleviates the transition from acute to chronic pain through the p38 MAPK/TNF-α signalling pathway in the spinal dorsal horn

(2021) Ying Jin et al.   Acupuncture in Medicine

Determining 5HT7R’s Involvement in Modifying the Antihyperalgesic Effects of Electroacupuncture on Rats With Recurrent Migraine

(2021) Lu Liu et al.   Frontiers in Neuroscience

Electroacupuncture-Induced Muscular Inflammatory Pain Relief Was Associated With Activation of Low-Threshold Mechanoreceptor Neurons and Inhibition of Wide Dynamic Range Neurons in Spinal Dorsal Horn

(2021) Cheng-Lin Duan-Mu et al.   Frontiers in Neuroscience

Electroacupuncture Ameliorates Chronic Inflammatory Pain-Related Anxiety by Activating PV Interneurons in the Anterior Cingulate Cortex

(2021) Fangbing Shao et al.   Frontiers in Neuroscience

Antinociceptive and Anti-Inflammatory Effects of Nypa fruticans Wurmb by Suppressing TRPV1 in the Sciatic Neuropathies

(2020) Mi-sun Kang et al.   Nutrients

Electroacupuncture suppresses the pain and pain-related anxiety of chronic inflammation in rats by increasing the expression of the NPS/NPSR system in the ACC

(2020) Junying Du et al.   BRAIN RESEARCH

CBS-Induced H2S Generation in Hippocampus Inhibits EA-Induced Analgesia

(2020) Wen-Jing Ren et al.   Evidence-based Complementary and Alternative Medicine

Effects and Mechanisms of Electroacupuncture on Chronic Inflammatory Pain and Depression Comorbidity in Mice

(2020) Hung-Yu Huang et al.   Evidence-based Complementary and Alternative Medicine

Electroacupuncture Relieves Pain and Attenuates Inflammation Progression Through Inducing IL-10 Production in CFA-Induced Mice

(2020) Mei-ling Yu et al.   INFLAMMATION

TRPV1 Responses in the Cerebellum Lobules V, VIa and VII Using Electroacupuncture Treatment for Inflammatory Hyperalgesia in Murine Model

(2020) Chanya Inprasit et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transient receptor potential V1 (TRPV1) modulates the therapeutic effects for comorbidity of pain and depression: The common molecular implication for electroacupuncture and omega-3 polyunsaturated fatty acids

(2020) Yi-Wen Lin et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulatory T cells and their derived cytokine, interleukin-35, reduce pain in experimental autoimmune encephalomyelitis

(2019) Samuel S Duffy et al.   JOURNAL OF NEUROSCIENCE

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

(2019) Raquel Guerrero-Alba et al.   Frontiers in Pharmacology

GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness

(2019) Dina L Juarez-Salinas et al.   BRAIN

Marine peptides as immunomodulators: Californiconus californicus-derived synthetic conotoxins induce IL-10 production by regulatory T cells (CD4+Foxp3+)

(2019) Daniela Zazueta-Favela et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Electroacupuncture Stimulation Alleviates CFA-Induced Inflammatory Pain Via Suppressing P2X3 Expression

(2019) Xuaner Xiang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electroacupuncture relieved visceral and referred hindpaw hypersensitivity in colitis rats by inhibiting tyrosine hydroxylase expression in the sixth lumbar dorsal root ganglia

(2019) Yi Li Wang et al.   NEUROPEPTIDES

The Purinergic System as a Pharmacological Target for the Treatment of Immune-Mediated Inflammatory Diseases

(2019) Luca Antonioli et al.   PHARMACOLOGICAL REVIEWS

Distal Electroacupuncture at the LI4 Acupoint Reduces CFA-Induced Inflammatory Pain via the Brain TRPV1 Signaling Pathway

(2019) Chia-Ming Yen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Augmented Mechanical Forces of the Surface-Modified Nanoporous Acupuncture Needles Elicit Enhanced Analgesic Effects

(2019) Sun-Jeong Bae et al.   Frontiers in Neuroscience

The Role of Transient Receptor Potential Vanilloid 1 in Common Diseases of the Digestive Tract and the Cardiovascular and Respiratory System

(2019) Qian Du et al.   Frontiers in Physiology

Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain

(2019) Yuheng Li et al.   Journal of Pain Research

Erbin in amygdala parvalbumin-positive neurons modulates anxiety-like behaviors

(2019) Zheng-Yi Luo et al.   BIOLOGICAL PSYCHIATRY

Acupuncture Alleviates Rheumatoid Arthritis by Immune-Network Modulation

(2018) Yuan Xu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Electroacupuncture inhibits NLRP3 inflammasome activation through CB2 receptors in inflammatory pain

(2018) Fang Gao et al.   BRAIN BEHAVIOR AND IMMUNITY

Anxiolytic effect of CPEB1 knockdown on the amygdala of a mouse model of inflammatory pain

(2018) Jiao Yue et al.   BRAIN RESEARCH BULLETIN

Electroacupuncture Alleviates Pain Responses and Inflammation in a Rat Model of Acute Gout Arthritis

(2018) Wenxin Chai et al.   Evidence-based Complementary and Alternative Medicine

The Mechanism of Hyperalgesia and Anxiety Induced by Remifentanil: Phosphorylation of GluR1 Receptors in the Anterior Cingulate Cortex

(2018) Jie Zeng et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats

(2018) Na-Xi Tian et al.   JOURNAL OF NEUROSCIENCE

Neuropathic pain creates an enduring prefrontal cortex dysfunction corrected by the type II diabetic drug metformin but not by gabapentin

(2018) Stephanie Shiers et al.   JOURNAL OF NEUROSCIENCE

Parameter-specific analgesic effects of electroacupuncture mediated by degree of regulation TRPV1 and P2X3 in inflammatory pain in rats

(2018) J.Q. Fang et al.   LIFE SCIENCES

[EXPRESS] Chronic inflammatory pain induced GABAergic synaptic plasticity in the adult mouse anterior cingulate cortex

(2018) Kohei Koga et al.   Molecular Pain

Immune Cytokines and Their Receptors in Inflammatory Pain

(2018) Andrew D. Cook et al.   TRENDS IN IMMUNOLOGY

Low GRK2 Underlies Hyperalgesic Priming by Glial Cell-Derived Neurotrophic Factor

(2018) Hui-Jing Wang et al.   Frontiers in Pharmacology

P2X receptors and acupuncture analgesia

(2018) Yong Tang et al.   BRAIN RESEARCH BULLETIN

ICA69 mediates the anti-hyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal GluR2 phosphorylation via PICK1 in mice

(2018) Kunyuan Han et al.   PAIN

Electroacupuncture Inhibits Visceral Nociception via Somatovisceral Interaction at Subnucleus Reticularis Dorsalis Neurons in the Rat Medulla

(2018) Lingling Yu et al.   Frontiers in Neuroscience

Electroacupuncture potentiates peripheral CB2 receptor-inhibited chronic pain in a mouse model of knee osteoarthritis

(2018) Xiao-Cui Yuan et al.   Journal of Pain Research

Challenges in translational drug research in neuropathic and inflammatory pain: the prerequisites for a new paradigm

(2017) A. Taneja et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Electroacupuncture Inhibits the Activation of p38MAPK in the Central Descending Facilitatory Pathway in Rats with Inflammatory Pain

(2017) Man-Li Hu et al.   Evidence-based Complementary and Alternative Medicine

Noradrenergic inhibition of presynaptic TRPV1 channels: a new pathway of pain control

(2017) Emilio Carbone   JOURNAL OF PHYSIOLOGY-LONDON

CXCL1/CXCR2 signaling in pathological pain: Role in peripheral and central sensitization

(2017) Rangel L. Silva et al.   NEUROBIOLOGY OF DISEASE

The Effect of Opioids, Alcohol, and Nonsteroidal Anti-inflammatory Drugs on Fracture Union

(2017) Christopher J. Richards et al.   ORTHOPEDIC CLINICS OF NORTH AMERICA

Purinergic signaling in microglia in the pathogenesis of neuropathic pain

(2017) Kazuhide INOUE   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages

(2017) W. K. Eddie Ip et al.   SCIENCE

Nociceptor Sensory Neuron–Immune Interactions in Pain and Inflammation

(2017) Felipe A. Pinho-Ribeiro et al.   TRENDS IN IMMUNOLOGY

Electroacupuncture alleviates the inflammatory response via effects on M1 and M2 macrophages after spinal cord injury

(2017) Jiagui Zhao et al.   Acupuncture in Medicine

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

(2017) Maria Cristina Marrone et al.   Nature Communications

Inflammatory Changes in Paravertebral Sympathetic Ganglia in Two Rat Pain Models

(2017) Ai-Ling Li et al.   Neuroscience Bulletin

Electroacupuncture alleviates neuromuscular dysfunction in an experimental rat model of immobilization

(2017) Jun Yang et al.   Oncotarget

Electroacupuncture Attenuates Induction of Inflammatory Pain by Regulating Opioid and Adenosine Pathways in Mice

(2017) Hsien-Yin Liao et al.   Scientific Reports

Role of Transient Receptor Potential Vanilloid 1 in Electroacupuncture Analgesia on Chronic Inflammatory Pain in Mice

(2017) Jun Yang et al.   Biomed Research International

Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

(2017) Sandeep Dembla et al.   eLife

The Effect of Electroacupuncture on PKMzeta in the ACC in Regulating Anxiety-Like Behaviors in Rats Experiencing Chronic Inflammatory Pain

(2017) Junying Du et al.   NEURAL PLASTICITY

Peripheral Interaction of Resolvin D1 and E1 with Opioid Receptor Antagonists for Antinociception in Inflammatory Pain in Rats

(2017) Beatrice Oehler et al.   Frontiers in Molecular Neuroscience

Ionotropic P2X ATP Receptor Channels Mediate Purinergic Signaling in Mouse Odontoblasts

(2017) Yuta Shiozaki et al.   Frontiers in Physiology

Electroacupuncture Attenuates CFA-induced Inflammatory Pain by suppressing Nav1.8 through S100B, TRPV1, Opioid and Adenosine Pathways in Mice

(2017) Hsien-Yin Liao et al.   Scientific Reports

Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s

(2017) Harsharan S. Bhatia et al.   Scientific Reports

The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain

(2016) Ke Wang et al.   ANESTHESIA AND ANALGESIA

The CB2 receptor and its role as a regulator of inflammation

(2016) Caroline Turcotte et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Effects of Zusanli and Ashi Acupoint Electroacupuncture on Repair of Skeletal Muscle and Neuromuscular Junction in a Rabbit Gastrocnemius Contusion Model

(2016) Zhan-ge Yu et al.   Evidence-based Complementary and Alternative Medicine

Effects of Electroacupuncture for Knee Osteoarthritis: A Systematic Review and Meta-Analysis

(2016) Jae-Woo Shim et al.   Evidence-based Complementary and Alternative Medicine

Capsaicin, Nociception and Pain

(2016) Bárbara Frias et al.   MOLECULES

Protein kinase M ζ and the maintenance of long-term memory

(2016) Yang Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Cannabinoid Type 2 Receptors Mediate a Cell Type-Specific Plasticity in the Hippocampus

(2016) A. Vanessa Stempel et al.   NEURON

Adenosine receptor targets for pain

(2016) J. Sawynok   NEUROSCIENCE

Acupuncture-Induced Analgesia

(2016) Yong Tang et al.   NEUROSCIENTIST

Answering the call to address chronic pain in military service members and veterans: Progress in improving pain care and restoring health

(2016) Bruce A. Schoneboom et al.   NURSING OUTLOOK

Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

(2016) K. Koda et al.   OSTEOARTHRITIS AND CARTILAGE

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Resolution of Inflammation: What Controls Its Onset?

(2016) Michelle A. Sugimoto et al.   Frontiers in Immunology

Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages

(2016) Ping Ke et al.   PLoS One

Probing the Effects and Mechanisms of Electroacupuncture at Ipsilateral or Contralateral ST36–ST37 Acupoints on CFA-induced Inflammatory Pain

(2016) Kung-Wen Lu et al.   Scientific Reports

Preclinical Assessment of Inflammatory Pain

(2015) Milind M. Muley et al.   CNS Neuroscience & Therapeutics

Phosphorylation of TRPV1 by cyclin-dependent kinase 5 promotes TRPV1 surface localization, leading to inflammatory thermal hyperalgesia

(2015) Jiao Liu et al.   EXPERIMENTAL NEUROLOGY

Epigenetic Regulation of Genes That Modulate Chronic Stress-Induced Visceral Pain in the Peripheral Nervous System

(2015) Shuangsong Hong et al.   GASTROENTEROLOGY

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

(2015) L. Vincent et al.   HAEMATOLOGICA

Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway

(2015) Hua-Dong Ni et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Prevalence of chronic pain in low-income and middle-income countries: a systematic review and meta-analysis

(2015) Tracy Jackson et al.   LANCET

The importance of TRPV1-sensitisation factors for the development of neuropathic pain

(2015) Natalia Malek et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

ThermoTRPs and Pain

(2015) Robyn J Laing et al.   NEUROSCIENTIST

Cannabinoid receptor-specific mechanisms to alleviate pain in sickle cell anemia via inhibition of mast cell activation and neurogenic inflammation

(2015) L. Vincent et al.   HAEMATOLOGICA

Fractalkine Signaling and Microglia Functions in the Developing Brain

(2015) Isabelle Arnoux et al.   NEURAL PLASTICITY

Interneuron cell types are fit to function

(2014) Adam Kepecs et al.   NATURE

Neuregulin-ERBB Signaling in the Nervous System and Neuropsychiatric Diseases

(2014) Lin Mei et al.   NEURON

CXCL10 Controls Inflammatory Pain via Opioid Peptide-Containing Macrophages in Electroacupuncture

(2014) Ying Wang et al.   PLoS One

Synaptic plasticity in pathological pain

(2014) Ceng Luo et al.   TRENDS IN NEUROSCIENCES

Mechanisms of Acupuncture–Electroacupuncture on Persistent Pain

(2013) Ruixin Zhang et al.   ANESTHESIOLOGY

Cannabinoid Receptor 2: Potential Role in Immunomodulation and Neuroinflammation

(2013) Slava Rom et al.   Journal of Neuroimmune Pharmacology

Intervention of Electroacupuncture on Spinal p38 MAPK/ATF-2/VR-1 Pathway in Treating Inflammatory Pain Induced by CFA in Rats

(2013) Jian-Qiao Fang et al.   Molecular Pain

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Intrathecal cannabilactone CB2R agonist, AM1710, controls pathological pain and restores basal cytokine levels

(2012) Jenny L. Wilkerson et al.   PAIN

Glial TNFα in the Spinal Cord Regulates Neuropathic Pain Induced by HIV gp120 Application in Rats

(2011) Wenwen Zheng et al.   Molecular Pain

Targeting astrocyte signaling for chronic pain

(2010) Yong-Jing Gao et al.   Neurotherapeutics

Spinal cord protein interacting with C kinase 1 is required for the maintenance of complete Freundʼs adjuvant-induced inflammatory pain but not for incision-induced post-operative pain

(2010) Fidelis E. Atianjoh et al.   PAIN

ErbB4 in parvalbumin-positive interneurons is critical for neuregulin 1 regulation of long-term potentiation

(2010) Y.-J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acupuncture Analgesia: I. The Scientific Basis

(2009) Shu-Ming Wang et al.   ANESTHESIA AND ANALGESIA

Mycobacteria Attenuate Nociceptive Responses by Formyl Peptide Receptor Triggered Opioid Peptide Release from Neutrophils

(2009) Heike L. Rittner et al.   PLoS Pathogens

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE