ThermoTRPs and Pain

Regulation of TRPV1 Ion Channel by Phosphoinositide (4,5)-Bisphosphate

(2014) Eric N. Senning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of (R)-1-(7-Chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): A Temperature-Neutral Transient Receptor Potential Vanilloid-1 (TRPV1) Antagonist with Analgesic Efficacy

(2014) Eric A. Voight et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Basal Thermal Sensitivity of the TRPV1 Ion Channel Is Determined by PKC II

(2014) L. Li et al.   JOURNAL OF NEUROSCIENCE

A technique to measure cold adaptation in freely behaving mice

(2014) Daniel S. Brenner et al.   JOURNAL OF NEUROSCIENCE METHODS

Acid Evoked Thermal Hyperalgesia Involves Peripheral P2Y1 Receptor Mediated TRPV1 Phosphorylation in a Rodent Model of Thrombus Induced Ischemic Pain

(2014) Soon-Gu Kwon et al.   Molecular Pain

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

(2014) Yong Chen et al.   PAIN

TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis

(2014) Jennifer J. DeBerry et al.   PAIN

Acute Heat-Evoked Temperature Sensation Is Impaired but Not Abolished in Mice Lacking TRPV1 and TRPV3 Channels

(2014) Irène Marics et al.   PLoS One

Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

(2014) Lavanya Moparthi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?

(2013) Sander J M van Wanrooij et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain

(2013) S Kelly et al.   ANNALS OF THE RHEUMATIC DISEASES

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

The anti-diabetic drug glibenclamide is an agonist of the transient receptor potential Ankyrin 1 (TRPA1) ion channel

(2013) Alexandru Babes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Artemin, a Glial Cell Line-Derived Neurotrophic Factor Family Member, Induces TRPM8-Dependent Cold Pain

(2013) E. K. Lippoldt et al.   JOURNAL OF NEUROSCIENCE

The Cellular Code for Mammalian Thermosensation

(2013) L. A. Pogorzala et al.   JOURNAL OF NEUROSCIENCE

TRPV1 and TRPA1 Antagonists Prevent the Transition of Acute to Chronic Inflammation and Pain in Chronic Pancreatitis

(2013) E. S. Schwartz et al.   JOURNAL OF NEUROSCIENCE

A Sensory-Labeled Line for Cold: TRPM8-Expressing Sensory Neurons Define the Cellular Basis for Cold, Cold Pain, and Cooling-Mediated Analgesia

(2013) W. M. Knowlton et al.   JOURNAL OF NEUROSCIENCE

Polypeptide Modulators of TRPV1 Produce Analgesia without Hyperthermia

(2013) Yaroslav Andreev et al.   Marine Drugs

TRPV1 structures in distinct conformations reveal activation mechanisms

(2013) Erhu Cao et al.   NATURE

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

(2013) Erhu Cao et al.   NEURON

TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain

(2013) Boyi Liu et al.   PAIN

Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

(2013) Yong Chen et al.   PAIN

TRPV1 and TRPV4 Play Pivotal Roles in Delayed Onset Muscle Soreness

(2013) Hiroki Ota et al.   PLoS One

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli

(2013) Anna Garcia-Elias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pirt functions as an endogenous regulator of TRPM8

(2013) Zongxiang Tang et al.   Nature Communications

Opiates Modulate Thermosensation by Internalizing Cold Receptor TRPM8

(2013) George Shapovalov et al.   Cell Reports

The Molecular and Cellular Basis of Cold Sensation

(2012) David D. McKemy   ACS Chemical Neuroscience

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia

(2012) Raul R. Calvo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of PAR2receptors sensitizes primary afferents and causes leukocyte rolling and adherence in the rat knee joint

(2012) FA Russell et al.   BRITISH JOURNAL OF PHARMACOLOGY

Aberrant TRPV1 Expression in Heat Hyperalgesia Associated with Trigeminal Neuropathic Pain

(2012) Hiroko Urano et al.   International Journal of Medical Sciences

Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin is Caused by the Enhanced Responsiveness of TRPA1 in Mice

(2012) Meng Zhao et al.   Molecular Pain

Direct inhibition of the cold-activated TRPM8 ion channel by Gαq

(2012) Xuming Zhang et al.   NATURE CELL BIOLOGY

Multisteric TRPV1 nocisensor: a target for analgesics

(2012) János Szolcsányi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

(2012) Lauri J. Moilanen et al.   Scientific Reports

Randomised clinical trial: the efficacy of a transient receptor potential vanilloid 1 antagonist AZD1386 in human oesophageal pain

(2011) A. L. Krarup et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Role of TRPM8 in dorsal root ganglion in nerve injury-induced chronic pain

(2011) Lin Su et al.   BMC NEUROSCIENCE

17(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception

(2011) S Bang et al.   BRITISH JOURNAL OF PHARMACOLOGY

TRPA1 and Substance P Mediate Colitis in Mice

(2011) Matthias A. Engel et al.   GASTROENTEROLOGY

Complex Regulation of the TRPM8 Cold Receptor Channel

(2011) Alexis Bavencoffe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Localization of the PIP2 Sensor of TRPV1 Ion Channels

(2011) Carmen A. Ufret-Vincenty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A TRPA1-dependent mechanism for the pungent sensation of weak acids

(2011) Yuanyuan Y. Wang et al.   JOURNAL OF GENERAL PHYSIOLOGY

Voltage- and cold-dependent gating of single TRPM8 ion channels

(2011) José A. Fernández et al.   JOURNAL OF GENERAL PHYSIOLOGY

TRPV3 and TRPV4 Ion Channels are Not Major Contributors to Mouse Heat Sensation

(2011) Susan M Huang et al.   Molecular Pain

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain

(2011) Y. Chen et al.   NEUROSCIENCE

Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity

(2011) Tamara King et al.   PAIN

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation

(2011) Jun Chen et al.   PAIN

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Modular thermal sensors in temperature-gated transient receptor potential (TRP) channels

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin

(2011) Takashi Miyamoto et al.   Nature Communications

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

(2010) Eugene Ceppa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

(2010) Elizabeth S. Fernandes et al.   ARTHRITIS AND RHEUMATISM

Synergistic Role of TRPV1 and TRPA1 in Pancreatic Pain and Inflammation

(2010) Erica S. Schwartz et al.   GASTROENTEROLOGY

Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

(2010) E. Zakharian et al.   JOURNAL OF NEUROSCIENCE

TRPA1 Contributes to Cold Hypersensitivity

(2010) D. del Camino et al.   JOURNAL OF NEUROSCIENCE

Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect

(2010) T. Watabiki et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Transient Receptor Potential Vanilloid 1 is Essential for Cisplatin-Induced Heat Hyperalgesia in Mice

(2010) Lauren E Ta et al.   Molecular Pain

Sensitization of Capsaicin and Icilin Responses in Oxaliplatin Treated Adult Rat DRG Neurons

(2010) Uma Anand et al.   Molecular Pain

TRPA1 Modulation of Spontaneous and Mechanically Evoked Firing of Spinal Neurons in Uninjured, Osteoarthritic, and Inflamed Rats

(2010) Steve McGaraughty et al.   Molecular Pain

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain

(2010) Jörg Grandl et al.   NATURE NEUROSCIENCE

A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

(2010) Barbara Kremeyer et al.   NEURON

TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo

(2010) Wendy M. Knowlton et al.   PAIN

Thermosensitive TRP channel pore turret is part of the temperature activation pathway

(2010) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Attenuation of Mechanical Hypersensitivity by an Antagonist of the TRPA1 Ion Channel in Diabetic Animals

(2009) Hong Wei et al.   ANESTHESIOLOGY

Involvement of transient receptor potential vanilloid 1 receptors in protease-activated receptor-2-induced joint inflammation and nociception

(2009) Zs. Helyes et al.   EUROPEAN JOURNAL OF PAIN

Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons

(2009) Susanne Staaf et al.   GENE EXPRESSION PATTERNS

TRPV1 Is Activated by Both Acidic and Basic pH

(2009) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels

(2009) Thomas E. Taylor-Clark et al.   JOURNAL OF PHYSIOLOGY-LONDON

Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice

(2009) Punam Gauchan et al.   NEUROSCIENCE LETTERS

The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation

(2009) Diogo Santos M. da Costa et al.   PAIN

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

(2009) Sravan Mandadi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The Contribution of TRPM8 and TRPA1 Channels to Cold Allodynia and Neuropathic Pain

(2009) Ombretta Caspani et al.   PLoS One

The vanilloid transient receptor potential channel TRPV4: From structure to disease

(2009) Wouter Everaerts et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Interaction with Phosphoinositides Confers Adaptation onto the TRPV1 Pain Receptor

(2009) Jing Yao et al.   PLOS BIOLOGY

Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate

(2008) Donghee Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain

(2008) A Akbar et al.   GUT

Visualizing Cold Spots: TRPM8-Expressing Sensory Neurons and Their Projections

(2008) A. Dhaka et al.   JOURNAL OF NEUROSCIENCE

Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2

(2008) S. M. Huang et al.   JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Antihyperalgesic Effects of (R,E)-N-(2-Hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)-acrylamide (AMG8562), a Novel Transient Receptor Potential Vanilloid Type 1 Modulator That Does Not Cause Hyperthermia in Rats

(2008) S. G. Lehto et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

NGX-4010, a high-concentration capsaicin patch, for the treatment of postherpetic neuralgia: a randomised, double-blind study

(2008) Miroslav Backonja et al.   LANCET NEUROLOGY

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

(2008) Lillian Cruz-Orengo et al.   Molecular Pain

HC-030031, a TRPA1 Selective Antagonist, Attenuates Inflammatory- and Neuropathy-Induced Mechanical Hypersensitivity

(2008) Samer R Eid et al.   Molecular Pain

Activation of TRPA1 by Farnesyl Thiosalicylic Acid

(2008) M. Maher et al.   MOLECULAR PHARMACOLOGY

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Pharmacological blockade of the vanilloid receptor TRPV1 elicits marked hyperthermia in humans

(2008) Narender R. Gavva et al.   PAIN

Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators

(2008) Yuji Karashima et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Distribution and Function of the Hydrogen Sulfide–Sensitive TRPA1 Ion Channel in Rat Urinary Bladder

(2007) Tomi Streng et al.   EUROPEAN UROLOGY