Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

Possible role of hippocampal GPR55 in spatial learning and memory in rats

(2018) Bruno A. Marichal-Cancino et al.   ACTA NEUROBIOLOGIAE EXPERIMENTALIS

α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus

(2018) Huijie Ma (马会杰) et al.   JOURNAL OF NEUROSCIENCE

Comparative transcriptome profiling of the human and mouse dorsal root ganglia

(2018) Pradipta Ray et al.   PAIN

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

(2018) Jinjun Chen et al.   Cell Reports

Lysophosphatidylinositol-induced activation of the cation channel TRPV2 triggers glucagon-like peptide-1 secretion in enteroendocrine L cells

(2017) Kazuki Harada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treating pain on skin graft donor sites

(2017) Sarthak Sinha et al.   Journal of Trauma and Acute Care Surgery

GPR55: A therapeutic target for Parkinson's disease?

(2017) Marta Celorrio et al.   NEUROPHARMACOLOGY

Cannabidiol attenuates seizures and social deficits in a mouse model of Dravet syndrome

(2017) Joshua S. Kaplan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Continuous Intrathecal Infusion of Cannabinoid Receptor Agonists Attenuates Nerve Ligation–Induced Pain in Rats

(2017) Sheng-Jie Shiue et al.   REGIONAL ANESTHESIA AND PAIN MEDICINE

Treating pain on skin graft donor sites

(2017) Sarthak Sinha et al.   Journal of Trauma and Acute Care Surgery

Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-tetrahydrocannabinol in Patients WithProgressive Multiple Sclerosis

(2017) Guido van Amerongen et al.   CLINICAL THERAPEUTICS

Inflammatory and Neuropathic Nociception is Preserved in GPR55 Knockout Mice

(2017) Lawrence M. Carey et al.   Scientific Reports

Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm

(2016) Bruno A. Marichal-Cancino et al.   BEHAVIOURAL PHARMACOLOGY

Resolvin D2 Enhances Postischemic Revascularization While Resolving InflammationClinical Perspective

(2016) Michael J. Zhang et al.   CIRCULATION

CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016

(2016) Deborah Dowell et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Noradrenergic Locus Coeruleus pathways in pain modulation

(2016) Meritxell Llorca-Torralba et al.   NEUROSCIENCE

N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism

(2016) Bright N. Okine et al.   PAIN

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

(2016) Natalia Malek et al.   PHARMACOLOGICAL RESEARCH

Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal

(2015) Liting Deng et al.   BIOLOGICAL PSYCHIATRY

Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

(2015) Bjorn Jensen et al.   Current Pain and Headache Reports

Cannabinoids for Medical Use

(2015) Penny F. Whiting et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy

(2015) Mark S. Wallace et al.   JOURNAL OF PAIN

Hypothalamic paraventricular nucleus stimulation enhances c-Fos expression in spinal and supraspinal structures related to pain modulation

(2015) Miguel Condés-Lara et al.   NEUROSCIENCE RESEARCH

A multi-target approach for pain treatment

(2015) Natalia Malek et al.   PAIN

Synthesis of New 4-Aminoquinolines and Evaluation of Their In Vitro Activity against Chloroquine-Sensitive and Chloroquine-Resistant Plasmodium falciparum

(2015) Chandima S. K. Rajapakse et al.   PLoS One

Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord

(2015) A. T. Guy et al.   SCIENCE

Vulvodynia and proctodynia treated with topical baclofen 5 % and palmitoylethanolamide

(2014) Jan M. Keppel Hesselink et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Activation of GPR18 by cannabinoid compounds: a tale of biased agonism

(2014) Linda Console-Bram et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anandamide in primary sensory neurons: too much of a good thing?

(2014) João Sousa-Valente et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment

(2014) M. Serpell et al.   EUROPEAN JOURNAL OF PAIN

Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands

(2014) Mellar P Davis   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons

(2014) Abimael González-Hernández et al.   JOURNAL OF NEURAL TRANSMISSION

Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons

(2014) Z.-Y. Wang et al.   NEUROSCIENCE

Neuronal and immunological basis of action of antidepressants in chronic pain – clinical and experimental studies

(2014) Joanna Mika et al.   Pharmacological Reports

Analysis of anandamide- and lysophosphatidylinositol-induced inhibition of the vasopressor responses produced by sympathetic stimulation or noradrenaline in pithed rats

(2013) Bruno A. Marichal-Cancino et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evidence for the involvement of cannabinoid receptors' polymorphisms in the pathophysiology of human diseases

(2013) Ioanna Vasileiou et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain

(2013) Mary E. Lynch et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Cannabinoid and opioid interactions: Implications for opiate dependence and withdrawal

(2013) J.L. Scavone et al.   NEUROSCIENCE

A novel biological role for the phospholipid lysophosphatidylinositol in nociceptive sensitization via activation of diverse G-protein signalling pathways in sensory nerves in vivo

(2013) Vijayan Gangadharan et al.   PAIN

Piperazinyl carbamate fatty acid amide hydrolase inhibitors and transient receptor potential channel modulators as “dual-target” analgesics

(2013) Sabatino Maione et al.   PHARMACOLOGICAL RESEARCH

Facing the experience of pain: A neuropsychological perspective

(2013) Franco Fabbro et al.   Physics of Life Reviews

Endocannabinoid system and pain: an introduction

(2013) James J. Burston et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

N -arachidonoyl glycine induces macrophage apoptosis via GPR18

(2012) Rina Takenouchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterisation of cannabinoid 1 receptor expression in the perikarya, and peripheral and spinal processes of primary sensory neurons

(2012) Gabor Veress et al.   Brain Structure & Function

2012 cannabinoid themed section

(2012) Stephen PH Alexander   BRITISH JOURNAL OF PHARMACOLOGY

The dynamic nature of type 1 cannabinoid receptor (CB1) gene transcription

(2012) RB Laprairie et al.   BRITISH JOURNAL OF PHARMACOLOGY

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

(2012) J. Corey-Bloom et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Discovery of novel cannabinoid receptor ligands by a virtual screening approach: Further development of 2,4,6-trisubstituted 1,3,5-triazines as CB2 agonists

(2012) Sari Yrjölä et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Cannabinoid Receptors CB1and CB2Form Functional Heteromers in Brain

(2012) Lucía Callén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nabilone for the treatment of medication overuse headache: results of a preliminary double-blind, active-controlled, randomized trial

(2012) Luigi Alberto Pini et al.   JOURNAL OF HEADACHE AND PAIN

A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis

(2012) R. M. Langford et al.   JOURNAL OF NEUROLOGY

Low-Dose Vaporized Cannabis Significantly Improves Neuropathic Pain

(2012) Barth Wilsey et al.   JOURNAL OF PAIN

N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception

(2012) José Eduardo Roa-Coria et al.   LIFE SCIENCES

Anandamide and 2-arachidonoylglycerol: Pharmacological Properties, Functional Features, and Emerging Specificities of the Two Major Endocannabinoids

(2012) Antonio Luchicchi et al.   MOLECULAR NEUROBIOLOGY

The atypical cannabinoid O-1602 increases hind paw sensitisation in the chronic constriction injury model of neuropathic pain

(2012) Courtney Breen et al.   NEUROSCIENCE LETTERS

An enriched-enrolment, randomized withdrawal, flexible-dose, double-blind, placebo-controlled, parallel assignment efficacy study of nabilone as adjuvant in the treatment of diabetic peripheral neuropathic pain

(2012) Cory Toth et al.   PAIN

Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis

(2012) Antonio Gatti et al.   PAIN MEDICINE

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice

(2011) Lamont Booker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones

(2011) Alex Straiker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of Chronic, Heavy Cannabis Use on Executive Functions

(2011) Rebecca D. Crean et al.   Journal of Addiction Medicine

Resolution of inflammation by N-arachidonoylglycine

(2011) Sumner H. Burstein et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Resolvin D2 Is a Potent Endogenous Inhibitor for Transient Receptor Potential Subtype V1/A1, Inflammatory Pain, and Spinal Cord Synaptic Plasticity in Mice: Distinct Roles of Resolvin D1, D2, and E1

(2011) C.-K. Park et al.   JOURNAL OF NEUROSCIENCE

Spinal Cord Injuries Induce Changes in CB1 Cannabinoid Receptor and C-C Chemokine Expression in Brain Areas Underlying Circuitry of Chronic Pain Conditions

(2011) Friederike Knerlich-Lukoschus et al.   JOURNAL OF NEUROTRAUMA

The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

(2011) Niklas Schuelert et al.   NEUROSCIENCE LETTERS

The GPR55 agonist lysophosphatidylinositol directly activates intermediate-conductance Ca2+-activated K+ channels

(2011) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pharmacological characterization of AM1710, a putative cannabinoid CB2 agonist from the cannabilactone class: Antinociception without central nervous system side-effects

(2011) Elizabeth J. Rahn et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

(2011) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

The endogenous cannabinoid anandamide inhibits transient receptor potential vanilloid type 1 receptor-mediated currents in rat cultured primary sensory neurons

(2010) P. Sántha et al.   ACTA PHYSIOLOGICA HUNGARICA

Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol

(2010) Natsuo Ueda et al.   BIOFACTORS

N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor

(2010) Douglas McHugh et al.   BMC NEUROSCIENCE

Central and peripheral sites of action for CB2 receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats

(2010) Gin C Hsieh et al.   BRITISH JOURNAL OF PHARMACOLOGY

N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn

(2010) Hyo-Jin Jeong et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR55 ligands promote receptor coupling to multiple signalling pathways

(2010) Christopher M Henstridge et al.   BRITISH JOURNAL OF PHARMACOLOGY

The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment

(2010) Rudolf Schicho et al.   INFLAMMATORY BOWEL DISEASES

Lysophosphatidylinositol induces rapid phosphorylation of p38 mitogen-activated protein kinase and activating transcription factor 2 in HEK293 cells expressing GPR55 and IM-9 lymphoblastoid cells

(2010) S. Oka et al.   JOURNAL OF BIOCHEMISTRY

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism

(2010) Jason R Clapper et al.   NATURE NEUROSCIENCE

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

Paradoxical effects of the cannabinoid CB2 receptor agonist GW405833 on rat osteoarthritic knee joint pain

(2010) N. Schuelert et al.   OSTEOARTHRITIS AND CARTILAGE

A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain

(2010) Xiao Hong Yu et al.   PAIN

The evidence for pharmacological treatment of neuropathic pain

(2010) Nanna Brix Finnerup et al.   PAIN

Misdiagnosed Chronic Pelvic Pain: Pudendal Neuralgia Responding to a Novel Use of Palmitoylethanolamide: Table 1

(2010) Rocco Salvatore Calabrò et al.   PAIN MEDICINE

The GPR55 agonist lysophosphatidylinositol acts as an intracellular messenger and bidirectionally modulates Ca2+-activated large-conductance K+ channels in endothelial cells

(2010) Alexander I. Bondarenko et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

The dual fatty acid amide hydrolase/TRPV1 blocker, N-arachidonoyl-serotonin, relieves carrageenan-induced inflammation and hyperalgesia in mice

(2010) Barbara Costa et al.   PHARMACOLOGICAL RESEARCH

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Lack of Analgesia by Oral Standardized Cannabis Extract on Acute Inflammatory Pain and Hyperalgesia in Volunteers

(2009) Birgit Kraft et al.   ANESTHESIOLOGY

Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation

(2009) Michaël Monet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands

(2009) Enrico Morera et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: A prospective double-blind randomized placebo-controlled study

(2009) R.P. Agrawal et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Examining the roles of cannabinoids in pain and other therapeutic indications: a review

(2009) Dana Turcotte et al.   EXPERT OPINION ON PHARMACOTHERAPY

Lipid G Protein-coupled Receptor Ligand Identification Using β-Arrestin PathHunter™ Assay

(2009) Hong Yin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Responsiveness of the Orphan Receptor GPR55 to Cannabinoid Ligands

(2009) Ankur Kapur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoids as pharmacotherapies for neuropathic pain: From the bench to the bedside

(2009) Elizabeth J. Rahn et al.   Neurotherapeutics

Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain

(2009) Eva Martín-Sánchez et al.   PAIN MEDICINE

The Role of the Periaqueductal Gray in the Modulation of Pain in Males and Females: Are the Anatomy and Physiology Really that Different?

(2009) Dayna R. Loyd et al.   NEURAL PLASTICITY

Opioid Tolerance Development: A Pharmacokinetic/Pharmacodynamic Perspective

(2008) Emily O. Dumas et al.   AAPS Journal

MAP kinase and pain

(2008) Ru-Rong Ji et al.   BRAIN RESEARCH REVIEWS

Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways

(2008) M G Belvisi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Opioid-induced Hyperalgesia in Humans

(2008) Larry F. Chu et al.   CLINICAL JOURNAL OF PAIN

Efficacy of Opioids for Chronic Pain

(2008) Jane C. Ballantyne et al.   CLINICAL JOURNAL OF PAIN

Involvement of central cannabinoid CB2 receptor in reducing mechanical allodynia in a mouse model of neuropathic pain

(2008) Wataru Yamamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy?

(2008) Ellen Niederberger et al.   FASEB JOURNAL

The GPR55 ligand l-α-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation

(2008) Christopher M. Henstridge et al.   FASEB JOURNAL

Integrin clustering enables anandamide-induced Ca2+ signaling in endothelial cells via GPR55 by protection against CB1-receptor-triggered repression

(2008) M. Waldeck-Weiermair et al.   JOURNAL OF CELL SCIENCE

Cannabinoid Receptors: Where They are and What They do

(2008) K. Mackie   JOURNAL OF NEUROENDOCRINOLOGY

Signaling via CNS cannabinoid receptors

(2008) Ken Mackie   MOLECULAR AND CELLULAR ENDOCRINOLOGY

A CB2 receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: Contributions of spinal and peripheral CB2 receptors

(2008) S. McGaraughty et al.   NEUROSCIENCE

Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats

(2008) Fabiola Voznika Merriam et al.   NEUROSCIENCE LETTERS

Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons

(2008) Uma Anand et al.   PAIN

The putative cannabinoid receptor GPR55 plays a role in mechanical hyperalgesia associated with inflammatory and neuropathic pain

(2008) Penny C. Staton et al.   PAIN

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitroandin vivocharacterization of A-796260: a selective cannabinoid CB2receptor agonist exhibiting analgesic activity in rodent pain models

(2007) B B Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nabilone for the Treatment of Pain in Fibromyalgia

(2007) Ryan Quinlan Skrabek et al.   JOURNAL OF PAIN

Efficacy of Dronabinol as an Adjuvant Treatment for Chronic Pain Patients on Opioid Therapy

(2007) Sanjeet Narang et al.   JOURNAL OF PAIN

Actions of N-arachidonyl-glycine in a rat neuropathic pain model

(2007) Leeza A.Q. Vuong et al.   NEUROPHARMACOLOGY