Inflammasomes in human reproductive diseases

NLRP3 inflammasome is involved in testicular inflammation induced by lipopolysaccharide in mice

(2022) Michiya Sano et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inflammatory Caspases: Toward a Unified Model for Caspase Activation by Inflammasomes

(2022) Connie Ross et al.   Annual Review of Immunology

The role of inflammasomes in vascular cognitive impairment

(2022) Luting Poh et al.   Molecular Neurodegeneration

Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

(2022) Inga V. Hochheiser et al.   NATURE

The Role of NLRP3 Inflammasome Activation and Oxidative Stress in Varicocele-Mediated Male Hypofertility

(2022) Giulia Poli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inhibition of the NLRP3 inflammasome by progesterone is attenuated by abnormal autophagy induction in endometriotic cyst stromal cells: implications for endometriosis

(2022) JongYeob Choi et al.   MOLECULAR HUMAN REPRODUCTION

Effectiveness of NLRP3 Inhibitor as a Non-Hormonal Treatment for ovarian endometriosis

(2022) Mayuko Murakami et al.   Reproductive Biology and Endocrinology

Extracellular Vesicle-Associated MicroRNA-138-5p Regulates Embryo Implantation and Early Pregnancy by Adjusting GPR124

(2022) Hsien-Ming Wu et al.   Pharmaceutics

Polycystic ovary syndrome

(2022) Anju E Joham et al.   Lancet Diabetes & Endocrinology

The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses

(2022) Xiuhua Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Inflammation in preterm birth: Novel mechanism of preterm birth associated with innate and acquired immunity

(2022) Yasuyuki Negishi et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells

(2022) Yun Chen et al.   Journal of Ovarian Research

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

(2021) Meenakshi Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion

(2021) Fiorella Di Nicuolo et al.   MOLECULES

Seminal inflammasome activity in the adult varicocele

(2021) Mariana Camargo et al.   Human Fertility

Evaluation of inflammation and follicle depletion during ovarian ageing in mice

(2021) Carolina Lliberos et al.   Scientific Reports

Inhibition of the NLRP3 inflammasome prevents ovarian aging

(2021) José M. Navarro-Pando et al.   Science Advances

The Inflammasome Contributes to Depletion of the Ovarian Reserve During Aging in Mice

(2021) Carolina Lliberos et al.   Frontiers in Cell and Developmental Biology

E3 ubiquitin ligase TRIM24 deficiency promotes NLRP3/caspase‐1/IL‐1β‐mediated pyroptosis in endometriosis

(2021) Yuanyuan Hang et al.   CELL BIOLOGY INTERNATIONAL

Absorption, distribution, metabolism and excretion of hyaluronic acid during pregnancy: a matter of molecular weight

(2021) Vittorio Unfer et al.   Expert Opinion on Drug Metabolism & Toxicology

Chronic Low Grade Inflammation in Pathogenesis of PCOS

(2021) Ewa Rudnicka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Bacterial detection by NAIP/NLRC4 elicits prompt contractions of intestinal epithelial cell layers

(2021) Pilar Samperio Ventayol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased uterine NLRP3 inflammasome and leucocyte infiltration in a rat model of preeclampsia

(2021) Huiqian Zeng et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

European Association of Urology Guidelines on Sexual and Reproductive Health—2021 Update: Male Sexual Dysfunction

(2021) Andrea Salonia et al.   EUROPEAN UROLOGY

Pre-eclampsia

(2021) Lucy C Chappell et al.   LANCET

NLRP3 Promotes Endometrial Receptivity by Inducing Epithelial-Mesenchymal Transition of the Endometrial Epithelium

(2021) Xi Cheng et al.   MOLECULAR HUMAN REPRODUCTION

Varicocele-Mediated Male Infertility: From the Perspective of Testicular Immunity and Inflammation

(2021) Yiwei Fang et al.   Frontiers in Immunology

Inflammasomes and Fibrosis

(2021) Wen-Juan Zhang et al.   Frontiers in Immunology

NLRP3 Inflammasome Activation of Mast Cells by Estrogen via the Nuclear-Initiated Signaling Pathway Contributes to the Development of Endometriosis

(2021) Xinyue Guo et al.   Frontiers in Immunology

Overexpression of Interferon-Inducible Protein 16 Promotes Progression of Human Pancreatic Adenocarcinoma Through Interleukin-1β-Induced Tumor-Associated Macrophage Infiltration in the Tumor Microenvironment

(2021) Jing-Xian Chen et al.   Frontiers in Cell and Developmental Biology

Vitamin D decreases expression of NLRP1 and NLRP3 inflammasomes in placental explants from women with preeclampsia cultured with hydrogen peroxide

(2021) Priscila R. Nunes et al.   HUMAN IMMUNOLOGY

β-hydroxybutyrate suppresses NLRP3 inflammasome-mediated placental inflammation and lipopolysaccharide-induced fetal absorption

(2021) Yoshiki Hirata et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11

(2021) Zilin Li et al.   NATURE

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

(2021) Tingting Niu et al.   Nature Communications

Inhibition of HMGB1 Ameliorates the Maternal-Fetal Interface Destruction in Unexplained Recurrent Spontaneous Abortion by Suppressing Pyroptosis Activation

(2021) Damin Zhu et al.   Frontiers in Immunology

NLRP3 Activation and Its Relationship to Endothelial Dysfunction and Oxidative Stress: Implications for Preeclampsia and Pharmacological Interventions

(2021) Priscila Rezeck Nunes et al.   Cells

Elevated expression of IL-18 but not IL-1β gene is associated with NALP3 and AIM2 inflammasome in Polycystic Ovary Syndrome

(2020) Maryam Rostamtabar et al.   GENE

Inflammasomes—A Molecular Link for Altered Immunoregulation and Inflammation Mediated Vascular Dysfunction in Preeclampsia

(2020) Padma Murthi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

(2020) Jennifer E. Rowley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum Caspase-1 levels in women with polycystic ovary syndrome

(2020) Umit Cabus et al.   Taiwanese Journal of Obstetrics & Gynecology

Role of the NLRP3 Inflammasome in Preeclampsia

(2020) Koumei Shirasuna et al.   Frontiers in Endocrinology

The Inflammasome in Reproductive Biology: A Promising Target for Novel Therapies

(2020) Juan Pablo de Rivero Vaccari   Frontiers in Endocrinology

Caspase-11 Non-Canonical Inflammasome: Emerging Activator and Regulator of Infection-Mediated Inflammatory Responses

(2020) Young-Su Yi   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endometriosis

(2020) Krina T. Zondervan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunoregulation of the decidualization program: focus on the endoplasmic reticulum stress

(2020) Elizabeth Soczewski et al.   REPRODUCTION

Interleukin-1β and TNF-α systems in ovarian follicles and their roles during follicular development, oocyte maturation and ovulation

(2020) José R.V. Silva et al.   ZYGOTE

SIRT1 Alleviates LPS-Induced IL-1β Production by Suppressing NLRP3 Inflammasome Activation and ROS Production in Trophoblasts

(2020) Sumi Park et al.   Cells

Korean Red Ginseng Suppresses the Expression of Oxidative Stress Response and NLRP3 Inflammasome Genes in Aged C57BL/6 Mouse Ovaries

(2020) Sungwoo Chei et al.   Foods

AIM2 in health and disease: Inflammasome and beyond

(2020) Puja Kumari et al.   IMMUNOLOGICAL REVIEWS

Protective roles and mechanisms of rosmarinic acid in cyclophosphamide‐induced premature ovarian failure

(2020) Yang Yao et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

(2020) Maryam Rostamtabar et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immunoendocrine Markers of Stress in Seminal Plasma at IVF/ICSI Failure: a Preliminary Study

(2020) Marina Nikolaeva et al.   Reproductive Sciences

The NLRP3 Inflammasome: Metabolic Regulation and Contribution to Inflammaging

(2020) Allison K. Meyers et al.   Cells

NLRP3 INFLAMMASOME FUNCTION AND PYROPTOTIC CELL DEATH IN HUMAN PLACENTAL HOFBAUER CELLS

(2020) Vikki M. Abrahams et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The NLRP3 inflammasome: Mechanism of action, role in disease and therapies

(2020) Li Wang et al.   MOLECULAR ASPECTS OF MEDICINE

NLRP3 inflammasome in endothelial dysfunction

(2020) Baochen Bai et al.   Cell Death & Disease

Effects of IL‐18 on the proliferation and steroidogenesis of bovine theca cells: Possible roles in the pathogenesis of polycystic ovary syndrome

(2020) Hong yuan Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Male infertility

(2020) Ashok Agarwal et al.   LANCET

An overview of the non-canonical inflammasome

(2020) Kevin P. Downs et al.   MOLECULAR ASPECTS OF MEDICINE

Inflamm-Aging: A New Mechanism Affecting Premature Ovarian Insufficiency

(2019) Yaoqi Huang et al.   Journal of Immunology Research

MicroRNA-184 promotes apoptosis of trophoblast cells via targeting WIG1 and induces early spontaneous abortion

(2019) Yuan Zhang et al.   Cell Death & Disease

Silibinin Downregulates the NF-κB Pathway and NLRP1/NLRP3 Inflammasomes in Monocytes from Pregnant Women with Preeclampsia

(2019) Mariana Leticia Matias et al.   MOLECULES

Chronic low-grade inflammation in polycystic ovary syndrome: is there a (patho)-physiological role for interleukin-1?

(2019) Milica Popovic et al.   Seminars in Immunopathology

Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra‐amniotic inflammation or intra‐amniotic infection

(2019) Nardhy Gomez‐Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Oxidative stress and male infertility: current knowledge of pathophysiology and role of antioxidant therapy in disease management

(2019) Erfaneh Barati et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Free Fatty Acid Receptors in Health and Disease

(2019) Ikuo Kimura et al.   PHYSIOLOGICAL REVIEWS

Recent Insights on Inflammasomes, Gasdermin Pores, and Pyroptosis

(2019) Nathalia M. de Vasconcelos et al.   Cold Spring Harbor Perspectives in Biology

Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic Escherichia coli- Induced Orchitis

(2019) Ying Li et al.   Frontiers in Immunology

Inflammasomes: Their Role in Normal and Complicated Pregnancies

(2019) Nardhy Gomez-Lopez et al.   JOURNAL OF IMMUNOLOGY

Allopurinol inhibits excess glucose-induced trophoblast IL-1b and ROS production

(2019) Masaru Negi et al.   REPRODUCTION

Expression and Contribution of NLRP3 Inflammasome During the Follicular Development Induced by PMSG

(2019) Zhenghong Zhang et al.   Frontiers in Cell and Developmental Biology

Cardiometabolic health in offspring of women with PCOS compared to healthy controls: a systematic review and individual participant data meta-analysis

(2019) Marlise N Gunning et al.   HUMAN REPRODUCTION UPDATE

Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages

(2019) Lisa M. Rogers et al.   PLACENTA

Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors

(2019) Shi-Bin Cheng et al.   Cell Death & Disease

NOD-like receptor pyrin domain-containing-3 (NLRP3) regulates inflammation-induced pro-labor mediators in human myometrial cells

(2018) Ratana Lim et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The biological basis and prevention of preterm birth

(2018) Gian Carlo Di Renzo et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Risk for and consequences of endometriosis: A critical epidemiologic review

(2018) A.L. Shafrir et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts

(2018) G. S. Stødle et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Induction of systemic inflammation by hyaluronan and hsp70 in women with pre-eclampsia

(2018) Mariana Romão-Veiga et al.   CYTOKINE

Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators

(2018) Melissa J. Mulla et al.   Arthritis & Rheumatology

The Confluence of Sex Hormones and Aging on Immunity

(2018) Melanie R. Gubbels Bupp et al.   Frontiers in Immunology

NLRP3 inflammasome activation in inflammaging

(2018) Eicke Latz et al.   SEMINARS IN IMMUNOLOGY

Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells

(2018) E. Grasso et al.   Scientific Reports

Omega-3 Polyunsaturated Fatty Acids Reduce Preterm Labor by Inhibiting Trophoblast Cathepsin S and Inflammasome Activation

(2018) Cheng Yi Chen et al.   CLINICAL SCIENCE

Ovulation: Parallels with Inflammatory Processes

(2018) Diane M Duffy et al.   ENDOCRINE REVIEWS

Hofbauer Cells: Their Role in Healthy and Complicated Pregnancy

(2018) Leticia Reyes et al.   Frontiers in Immunology

Adolescent Obesity and Insulin Resistance: Roles of Ectopic Fat Accumulation and Adipose Inflammation

(2017) Sonia Caprio et al.   GASTROENTEROLOGY

Glibenclamide inhibits NLRP3 inflammasome-mediated IL-1β secretion in human trophoblasts

(2017) Kazuhiro Tamura et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Advanced glycation end products regulate interleukin-1β production in human placenta

(2017) Kotomi SENO et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Increased expression of NLRP3 inflammasome in placentas from pregnant women with severe preeclampsia

(2017) Ingrid C.Weel et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis

(2017) Nardhy Gomez-Lopez et al.   Reproductive Sciences

A Role for the Inflammasome in Spontaneous Labor at Term

(2016) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

HMGB1 Induces an Inflammatory Response in the Chorioamniotic Membranes That Is Partially Mediated by the Inflammasome

(2016) O. Plazyo et al.   BIOLOGY OF REPRODUCTION

NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus

(2016) Tatiana N. Silveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammosome in the human endometrium: further step in the evaluation of the “maternal side”

(2016) Silvia D'Ippolito et al.   FERTILITY AND STERILITY

Immune-inflammation gene signatures in endometriosis patients

(2016) Soo Hyun Ahn et al.   FERTILITY AND STERILITY

ESHRE Guideline: management of women with premature ovarian insufficiency

(2016)   HUMAN REPRODUCTION

The relationship of seminal transforming growth factor-β1 and interleukin-18 with reproductive success in women exposed to seminal plasma during IVF/ICSI treatment

(2016) Marina A. Nikolaeva et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Overexpression of IL-18 in the Proliferative Phase Endometrium of Patients With Polycystic Ovary Syndrome

(2016) Xiaoyu Long et al.   Reproductive Sciences

Adiponectin: a versatile player of innate immunity

(2016) Yan Luo et al.   Journal of Molecular Cell Biology

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Drivers of age-related inflammation and strategies for healthspan extension

(2015) Emily L. Goldberg et al.   IMMUNOLOGICAL REVIEWS

Lipopolysaccharide Primes the NALP3 Inflammasome by Inhibiting Its Ubiquitination and Degradation Mediated by the SCFFBXL2E3 Ligase

(2015) SeungHye Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling

(2015) Christina Antonopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1

(2015) Yang Chen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

NOD-Like Receptors: Versatile Cytosolic Sentinels

(2015) Vinicius Motta et al.   PHYSIOLOGICAL REVIEWS

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

Endogenous and Uric Acid-Induced Activation of NLRP3 Inflammasome in Pregnant Women with Preeclampsia

(2015) Mariana Leticia Matias et al.   PLoS One

Glucose and Metformin Modulate Human First Trimester Trophoblast Function: a Model and Potential Therapy for Diabetes-Associated Uteroplacental Insufficiency

(2014) Christina S. Han et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Nanosilica-induced placental inflammation and pregnancy complications: Different roles of the inflammasome components NLRP3 and ASC

(2014) Koumei Shirasuna et al.   Nanotoxicology

Silibinin attenuates oxidative metabolism and cytokine production by monocytes from preeclamptic women

(2013) R. Cristofalo et al.   FREE RADICAL RESEARCH

AGEs, contributors to placental bed vascular changes leading to preeclampsia

(2013) L. Guedes-Martins et al.   FREE RADICAL RESEARCH

Linkage of bacterial colonization of skin and the urticaria-like rash of NLRP3-mediated autoinflammatory syndromes through mast cell-derived TNF-α

(2013) Yuumi Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A leading role for the immune system in the pathophysiology of preeclampsia

(2013) Estibalitz Laresgoiti-Servitje   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Involvement of the inflammasome in abnormal semen quality of men with spinal cord injury

(2012) Xianyang Zhang et al.   FERTILITY AND STERILITY

The ageing ovary and uterus: new biological insights

(2012) S.M. Nelson et al.   HUMAN REPRODUCTION UPDATE

Silibinin modulates the NF-κb pathway and pro-inflammatory cytokine production by mononuclear cells from preeclamptic women

(2012) Vanessa S. Innocenti Giorgi et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Uric Acid Induces Trophoblast IL-1β Production Via the Inflammasome: Implications for the Pathogenesis of Preeclampsia

(2011) Melissa J. Mulla et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Follicular Proinflammatory Cytokines and Chemokines as Markers of IVF Success

(2011) Aili Sarapik et al.   Clinical & Developmental Immunology

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Toll-like receptors 2 and 4 and the cryopyrin inflammasome in normal pregnancy and pre-eclampsia

(2010) F Xie et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Antioxidant Systems and Oxidative Stress in the Testes

(2010) R. John Aitken et al.   Oxidative Medicine and Cellular Longevity

The impact of peritoneal fluid from healthy women and from women with endometriosis on sperm DNA and its relationship to the sperm deformity index

(2009) Gihan Mansour et al.   FERTILITY AND STERILITY