A Role for the Inflammasome in Spontaneous Preterm Labor With Acute Histologic Chorioamnionitis

Cytokines in noninvasively obtained amniotic fluid as predictors of fetal inflammatory response syndrome

(2016) Mirjam Kunze et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Mathematical Modeling of the Biomarker Milieu to Characterize Preterm Birth and Predict Adverse Neonatal Outcomes

(2016) Christina N. Cordeiro et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inflammatory predictors of neurologic disability after preterm premature rupture of membranes

(2015) Jennifer Armstrong-Wells et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

282: Chorioamnionitis induced by intramniotic injection of IL1, LPS or Ureaplasma parvum is associated with an altered microbiome in a primate model of inflammatory preterm birth (PTB)

(2015) Amanda Prince et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Evidence of perturbations of the cytokine network in preterm labor

(2015) Roberto Romero et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Classification of placental lesions

(2015) Raymond W. Redline   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Intra-Amniotic Administration of HMGB1 Induces Spontaneous Preterm Labor and Birth

(2015) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Inflammasome-Independent Regulation of IL-1-Family Cytokines

(2015) Mihai G. Netea et al.   Annual Review of Immunology

Neutrophil Recruitment and Activation in Decidua with Intra-Amniotic IL-1beta in the Preterm Rhesus Macaque1

(2015) Pietro Presicce et al.   BIOLOGY OF REPRODUCTION

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Evasion of inflammasome activation by microbial pathogens

(2015) Tyler K. Ulland et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques

(2015) Roberto Romero et al.   JOURNAL OF PERINATAL MEDICINE

Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis

(2015) Li Liu et al.   LANCET

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

Human caspase-4 mediates noncanonical inflammasome activation against gram-negative bacterial pathogens

(2015) Cierra N. Casson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chorioamnionitis Occurring in Women With Preterm Rupture of the Fetal Membranes Is Associated With a Dynamic Increase in mRNAs Coding Cytokines in the Maternal Circulation

(2015) Owen Stock et al.   Reproductive Sciences

Mechanisms of inflammasome activation: recent advances and novel insights

(2015) Sivapriya K. Vanaja et al.   TRENDS IN CELL BIOLOGY

A Novel Molecular Microbiologic Technique for the Rapid Diagnosis of Microbial Invasion of the Amniotic Cavity and Intra-Amniotic Infection in Preterm Labor with Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Mechanism of NLRP3 inflammasome activation

(2014) Fayyaz S. Sutterwala et al.   Annals of the New York Academy of Sciences

Human Fetal Membranes Generate Distinct Cytokine Profiles in Response to Bacterial Toll-Like Receptor and Nod-Like Receptor Agonists1

(2014) Mai Hoang et al.   BIOLOGY OF REPRODUCTION

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

Old, new and emerging functions of caspases

(2014) S Shalini et al.   CELL DEATH AND DIFFERENTIATION

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

(2014) Leigh A. Knodler et al.   Cell Host & Microbe

NLR proteins and parasitic disease

(2014) Gwendolyn M. Clay et al.   IMMUNOLOGIC RESEARCH

Cutting Edge: Alum Adjuvant Stimulates Inflammatory Dendritic Cells through Activation of the NALP3 Inflammasome

(2014) M. Kool et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Inflammasome Activation by Alum and Alum's Adjuvant Effect Are Mediated by NLRP3

(2014) H. Li et al.   JOURNAL OF IMMUNOLOGY

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

(2014) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

Caspase crosstalk: integration of apoptotic and innate immune signalling pathways

(2014) Emma M. Creagh   TRENDS IN IMMUNOLOGY

Amniotic fluid infection, inflammation, and colonization in preterm labor with intact membranes

(2013) C. Andrew Combs et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Cardiolipin and the Nlrp3 Inflammasome

(2013) Luke A.J. O’Neill   Cell Metabolism

Inflammasomes and host defenses against bacterial infections

(2013) Gregory I Vladimer et al.   CURRENT OPINION IN MICROBIOLOGY

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Regulation of Apoptosis and Innate Immune Stimuli in Inflammation-Induced Preterm Labor

(2013) M. K. Jaiswal et al.   JOURNAL OF IMMUNOLOGY

Annual Summary of Vital Statistics: 2010-2011

(2013) B. E. Hamilton et al.   PEDIATRICS

Amniotic Fluid Protein Profiles of Intraamniotic Inflammatory Response to Ureaplasma spp. and Other Bacteria

(2013) Marian Kacerovsky et al.   PLoS One

Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila

(2013) C. L. Case et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymyxin B Agonist Capture Therapy for Intrauterine Inflammation

(2013) Masatoshi Saito et al.   Reproductive Sciences

Biomarker Interactions Are Better Predictors of Spontaneous Preterm Birth

(2013) G. Bhat et al.   Reproductive Sciences

The Interplay of the Interleukin 1 System in Pregnancy and Labor

(2013) Yujing Jan Heng et al.   Reproductive Sciences

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

(2013) J. A. Hagar et al.   SCIENCE

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

Interleukin-18, more than a Th1 cytokine

(2013) Daniela Novick et al.   SEMINARS IN IMMUNOLOGY

Noncanonical Inflammasomes: Caspase-11 Activation and Effector Mechanisms

(2013) Petr Broz et al.   PLoS Pathogens

Interleukin-18 and IL-18 Binding Protein

(2013) Charles A. Dinarello et al.   Frontiers in Immunology

506: Intraamniotic interleukin-1 (IL1β) induces histologic chorioamnionitis and alters the microbiome in a primate model of inflammatory preterm birth

(2012) Kjersti Aagaard et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

(2012) Vijay A.K. Rathinam et al.   CELL

Caspase-4 Is Required for Activation of Inflammasomes

(2012) G. Sollberger et al.   JOURNAL OF IMMUNOLOGY

Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1

(2012) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

The frequency and clinical significance of intra-amniotic inflammation in women with preterm uterine contractility but without cervical change: do the diagnostic criteria for preterm labor need to be changed?

(2012) Sun Min Kim et al.   Journal of Maternal-Fetal & Neonatal Medicine

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications

(2012) Hannah Blencowe et al.   LANCET

Control of innate and adaptive immunity by the inflammasome

(2012) Ceren Ciraci et al.   MICROBES AND INFECTION

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Sensing and reacting to microbes through the inflammasomes

(2012) Luigi Franchi et al.   NATURE IMMUNOLOGY

Orchestrating Inflammasomes

(2012) L. Franchi et al.   SCIENCE

The inflammasome: in memory of Dr. Jurg Tschopp

(2011) M Dagenais et al.   CELL DEATH AND DIFFERENTIATION

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

NOD-like receptors and the innate immune system: Coping with danger, damage and death

(2011) Kristof Kersse et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Intracellular sensing of microbes and danger signals by the inflammasomes

(2011) Gabor L. Horvath et al.   IMMUNOLOGICAL REVIEWS

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Inflammatory response in acute chorioamnionitis

(2011) Raymond W. Redline   Seminars in Fetal & Neonatal Medicine

Inflammasome activation and IL-1β and IL-18 processing during infection

(2011) Frank L. van de Veerdonk et al.   TRENDS IN IMMUNOLOGY

The Inflammasomes: Molecular Effectors of Host Resistance Against Bacterial, Viral, Parasitic, and Fungal Infections

(2011) Alexander Skeldon et al.   Frontiers in Microbiology

Regulation of Interleukin-6 Expression in Human Decidual Cells and Its Potential Role in Chorioamnionitis

(2010) Charles J. Lockwood et al.   AMERICAN JOURNAL OF PATHOLOGY

Focal Increases of Fetal Macrophages in Placentas from Pregnancies with Histological Chorioamnionitis: Potential Role of Fibroblast Monocyte Chemotactic Protein-1

(2010) Paolo Toti et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Inflammasomes: current understanding and open questions

(2010) Franz Bauernfeind et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The inflammasomes: mechanisms of activation and function

(2010) Eicke Latz   CURRENT OPINION IN IMMUNOLOGY

Sterile inflammatory responses mediated by the NLRP3 inflammasome

(2010) Suzanne L. Cassel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes as microbial sensors

(2010) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observation

(2010) Ichchha Madan et al.   JOURNAL OF PERINATAL MEDICINE

The frequency, clinical significance and pathological features of chronic chorioamnionitis: a lesion associated with spontaneous preterm birth

(2010) Chong Jai Kim et al.   MODERN PATHOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The Enigma of Spontaneous Preterm Birth

(2010) Louis J. Muglia et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Sensing pathogens and danger signals by the inflammasome

(2009) Joao HF Pedra et al.   CURRENT OPINION IN IMMUNOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: TNF-  Mediates Sensitization to ATP and Silica via the NLRP3 Inflammasome in the Absence of Microbial Stimulation

(2009) L. Franchi et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome

(2009) R. Munoz-Planillo et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Associated Nucleotide-Binding Domain, Leucine-Rich Repeat Proteins and Inflammatory Diseases

(2009) S. Jha et al.   JOURNAL OF IMMUNOLOGY

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

(2009) Joseph A. Duncan et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome

(2009) S. Joly et al.   JOURNAL OF IMMUNOLOGY

Prenatal medicine: The child is the father of the man*

(2009) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

The preterm parturition syndrome and its implications for understanding the biology, risk assessment, diagnosis, treatment and prevention of preterm birth

(2009) Francesca Gotsch et al.   Journal of Maternal-Fetal & Neonatal Medicine

Amniotic fluid volume in intra-amniotic inflammation with and without culture-proven amniotic fluid infection in preterm premature rupture of membranes

(2009) Si Eun Lee et al.   JOURNAL OF PERINATAL MEDICINE

Increased Umbilical Cord Plasma Interleukin-1  Levels was Correlated with Adverse Outcomes of Neonatal Hypoxic-ischemic Encephalopathy

(2009) J. Liu et al.   JOURNAL OF TROPICAL PEDIATRICS

The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis

(2009) Luigi Franchi et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome: A sensor of immune danger signals

(2009) Suzanne L. Cassel et al.   SEMINARS IN IMMUNOLOGY

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

(2009) Stacey L. Demento et al.   VACCINE

Can placental pathology explain second-trimester pregnancy loss and subsequent pregnancy outcomes?

(2008) Sindhu K. Srinivas et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The frequency and significance of intraamniotic inflammation in patients with cervical insufficiency

(2008) Si Eun Lee et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

ORIGINAL ARTICLE: CXCL6 (Granulocyte Chemotactic Protein-2): A Novel Chemokine Involved in the Innate Immune Response of the Amniotic Cavity

(2008) Pooja Mittal et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

ESX-1-dependent cytolysis in lysosome secretion and inflammasome activation during mycobacterial infection

(2008) Ingrid C. Koo et al.   CELLULAR MICROBIOLOGY

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Inflammasomes: guardians of cytosolic sanctity

(2008) Mohamed Lamkanfi et al.   IMMUNOLOGICAL REVIEWS

Evidence of the involvement of caspase-1 under physiologic and pathologic cellular stress during human pregnancy: A link between the inflammasome and parturition

(2008) Francesca Gotsch et al.   Journal of Maternal-Fetal & Neonatal Medicine

Epidemiology and causes of preterm birth

(2008) Robert L Goldenberg et al.   LANCET

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE