Structural and functional insights into the enzymatic plasticity of the SARS-CoV-2 NiRAN domain

Structural basis for substrate selection by the SARS-CoV-2 replicase

(2023) Brandon F. Malone et al.   NATURE

Conserved Characteristics of NMPylation Activities of Alpha- and Betacoronavirus NiRAN Domains

(2023) Heiko Slanina et al.   JOURNAL OF VIROLOGY

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9

(2023) Nora Schmidt et al.   CELL

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

(2022) Ashleigh Shannon et al.   Nature Communications

Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants

(2022) Miaomiao Liu et al.   ACS Omega

A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors

(2022) Liming Yan et al.   CELL

Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms

(2021) Nicholas C. Huston et al.   MOLECULAR CELL

Coronavirus replication–transcription complex: Vital and selective NMPylation of a conserved site in nsp9 by the NiRAN-RdRp subunit

(2021) Heiko Slanina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain

(2021) Bing Wang et al.   NUCLEIC ACIDS RESEARCH

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein

(2021) Dene R. Littler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures and functions of coronavirus replication–transcription complexes and their relevance for SARS-CoV-2 drug design

(2021) Brandon Malone et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Structure of replicating SARS-CoV-2 polymerase

(2020) Hauke S. Hillen et al.   NATURE

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

(2020) Dene R. Littler et al.   iScience

UCSF ChimeraX : Structure visualization for researchers, educators, and developers

(2020) Eric F. Pettersen et al.   PROTEIN SCIENCE

Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis

(2020) Liming Yan et al.   CELL

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

MetaUniDec: High-Throughput Deconvolution of Native Mass Spectra

(2018) Deseree J. Reid et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

The Rabies Virus L Protein Catalyzes mRNA Capping with GDP Polyribonucleotidyltransferase Activity

(2016) Minako Ogino et al.   Viruses-Basel

Bayesian Deconvolution of Mass and Ion Mobility Spectra: From Binary Interactions to Polydisperse Ensembles

(2015) Michael T. Marty et al.   ANALYTICAL CHEMISTRY

Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses

(2015) Kathleen C. Lehmann et al.   NUCLEIC ACIDS RESEARCH

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Correction: In Vitro Reconstitution of SARS-Coronavirus mRNA Cap Methylation

(2014) Mickaël Bouvet et al.   PLoS Pathogens

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses

(2013) Rolf Hilgenfeld et al.   ANTIVIRAL RESEARCH

One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions

(2013) Giovanni Cardone et al.   JOURNAL OF STRUCTURAL BIOLOGY

Parallel Reaction Monitoring for High Resolution and High Mass Accuracy Quantitative, Targeted Proteomics

(2012) Amelia C. Peterson et al.   MOLECULAR & CELLULAR PROTEOMICS

Expression and Biochemical Characterization of the Human Enzyme N-Terminal Asparagine Amidohydrolase

(2011) Jason R. Cantor et al.   BIOCHEMISTRY

Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease

(2011) M. Frieman et al.   JOURNAL OF VIROLOGY

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Understanding the Functional Roles of Amino Acid Residues in Enzyme Catalysis

(2009) Gemma L. Holliday et al.   JOURNAL OF MOLECULAR BIOLOGY

Severe Acute Respiratory Syndrome Coronavirus nsp9 Dimerization Is Essential for Efficient Viral Growth

(2009) Z. J. Miknis et al.   JOURNAL OF VIROLOGY

Nucleic acid polymerases use a general acid for nucleotidyl transfer

(2009) Christian Castro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

(2009) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA