Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells

mTOR substrate phosphorylation in growth control

(2022) Stefania Battaglioni et al.   CELL

UALCAN: An update to the integrated cancer data analysis platform

(2022) Darshan Shimoga Chandrashekar et al.   NEOPLASIA

Characterizing unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family

(2022) Natasha J. Freidman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly

(2022) Edoardo Ratto et al.   Nature Communications

The rapidly evolving view of lysosomal storage diseases

(2021) Giancarlo Parenti et al.   EMBO Molecular Medicine

Structures and General Transport Mechanisms by the Major Facilitator Superfamily (MFS)

(2021) David Drew et al.   CHEMICAL REVIEWS

Glutathione and its precursors in cancer

(2021) Gloria Asantewaa et al.   CURRENT OPINION IN BIOTECHNOLOGY

Enhanced Intracellular Reactive Oxygen Species by Photodynamic Therapy Effectively Promotes Chemoresistant Cell Death

(2021) Xiaolin Xu et al.   International Journal of Biological Sciences

ROS in cancer therapy: the bright side of the moon

(2020) Bruno Perillo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines

(2020) Longfa Kou et al.   Asian Journal of Pharmaceutical Sciences

Rap1-GTPases control mTORC1 activity by coordinating lysosome organization with amino acid availability

(2020) Anders P. Mutvei et al.   Nature Communications

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

(2020) Boutaina Daher et al.   Frontiers in Oncology

Oxidative Stress in Cancer

(2020) John D. Hayes et al.   CANCER CELL

GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

(2020) Limor Avrahami et al.   CELLULAR SIGNALLING

The Complex Interplay between Antioxidants and ROS in Cancer

(2020) Isaac S. Harris et al.   TRENDS IN CELL BIOLOGY

Cysteine metabolic circuitries: druggable targets in cancer

(2020) Vasco D. B. Bonifácio et al.   BRITISH JOURNAL OF CANCER

MFSD12 mediates the import of cysteine into melanosomes and lysosomes

(2020) Charles H. Adelmann et al.   NATURE

Insights into L-type heteromeric amino acid transporters

(2019) Simon Newstead   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Tales of tails in transporters

(2019) Emmanuel Mikros et al.   Open Biology

Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

(2019) Jiajun Zhu et al.   Cell Metabolism

The Transsulfuration Pathway Makes, the Tumor Takes

(2019) Ross Weber et al.   Cell Metabolism

Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization

(2018) Luca Ponzoni et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney

(2018) Beatrice Paola Festa et al.   Nature Communications

Transporter oligomerisation: roles in structure and function

(2018) Cristina Cecchetti et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Modulating ROS to overcome multidrug resistance in cancer

(2018) Qingbin Cui et al.   DRUG RESISTANCE UPDATES

The role of cellular reactive oxygen species in cancer chemotherapy

(2018) Haotian Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

Bioinformatics-based analysis reveals elevated MFSD12 as a key promoter of cell proliferation and a potential therapeutic target in melanoma

(2018) Chuan-Yuan Wei et al.   ONCOGENE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

(2017) Evan C. Lien et al.   Science Signaling

The Lysosome as a Regulatory Hub

(2016) Rushika M. Perera et al.   Annual Review of Cell and Developmental Biology

Transporter oligomerization: form and function

(2016) Y. Alguel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The lysosome as a command-and-control center for cellular metabolism

(2016) Chun-Yan Lim et al.   JOURNAL OF CELL BIOLOGY

Lysosomal cystine accumulation promotes mitochondrial depolarization and induction of redox-sensitive genes in human kidney proximal tubular cells

(2016) Rodolfo Sumayao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Dynamics of mTORC1 activation in response to amino acids

(2016) Maria Manifava et al.   eLife

Structural Biology of the Major Facilitator Superfamily Transporters

(2015) Nieng Yan   Annual Review of Biophysics

Architecture of human mTOR complex 1

(2015) C. H. S. Aylett et al.   SCIENCE

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

(2014) Joanne L. Parker et al.   NATURE

Crystal structure of the plant dual-affinity nitrate transporter NRT1.1

(2014) Ji Sun et al.   NATURE

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Role of Glutathione in Cancer Progression and Chemoresistance

(2013) Nicola Traverso et al.   Oxidative Medicine and Cellular Longevity

Frequent Epigenetic Silencing of the Folate-Metabolising Gene Cystathionine-Beta-Synthase in Gastrointestinal Cancer

(2012) Hong Zhao et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Cancer cell killing via ROS: To increase or decrease, that is the question

(2010) Jie Wang et al.   CANCER BIOLOGY & THERAPY

Lysosomal disorders: From storage to cellular damage

(2008) Andrea Ballabio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH