TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome

Hedgehog and PDGF Signaling Intersect During Postnatal Lung Development

(2023) Ting-An Yie et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Arrhythmia and impaired myocardial function in heritable thoracic aortic disease: An international retrospective cohort study

(2022) Anthony Demolder et al.   European Journal of Medical Genetics

Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling

(2022) Wei Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Genetics and Typical Traits of Thoracic Aortic Aneurysm and Dissection

(2022) Jotte Rodrigues Bento et al.   Annual Review of Genomics and Human Genetics

Angiotensin receptor blockers and β blockers in Marfan syndrome: an individual patient data meta-analysis of randomised trials

(2022) Alex Pitcher et al.   LANCET

Non-aortic cardiovascular disease in Marfan syndrome: a nationwide epidemiological study

(2021) Niels H. Andersen et al.   Clinical Research in Cardiology

Mechanics of ascending aortas from TGFβ-1, -2, -3 haploinsufficient mice and elastase-induced aortopathy

(2021) Brooks A Lane et al.   JOURNAL OF BIOMECHANICS

Marfan syndrome

(2021) Dianna M. Milewicz et al.   Nature Reviews Disease Primers

Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome

(2021) Nazli Gharraee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta

(2021) Cristina Cavinato et al.   Frontiers in Cardiovascular Medicine

Developmental origins of mechanical homeostasis in the aorta

(2020) Sae‐Il Murtada et al.   DEVELOPMENTAL DYNAMICS

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

(2019) Elena Gallo MacFarlane et al.   JOURNAL OF CLINICAL INVESTIGATION

Absence of LTBP-3 attenuates the aneurysmal phenotype but not spinal effects on the aorta in Marfan syndrome

(2018) A. Korneva et al.   Biomechanics and Modeling in Mechanobiology

Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility

(2018) Arina Korneva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Comparison of 10 murine models reveals a distinct biomechanical phenotype in thoracic aortic aneurysms

(2017) C. Bellini et al.   Journal of the Royal Society Interface

TGF-β Family Signaling in Connective Tissue and Skeletal Diseases

(2017) Elena Gallo MacFarlane et al.   Cold Spring Harbor Perspectives in Biology

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

(2017) Hao Wei et al.   Journal of the American Heart Association

Post-mortem whole-exome sequencing (WES) with a focus on cardiac disease-associated genes in five young sudden unexplained death (SUD) cases

(2016) Jacqueline Neubauer et al.   INTERNATIONAL JOURNAL OF LEGAL MEDICINE

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic analysis of the contribution of LTBP-3 to thoracic aneurysm in Marfan syndrome

(2015) Lior Zilberberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of fibrillin 1 gene mutations in patients with bicuspid aortic valve (BAV) without Marfan syndrome

(2014) Guglielmina Pepe et al.   BMC Medical Genetics

Generation of mice carrying a knockout-first and conditional-ready allele of transforming growth factor beta2 gene

(2014) A. S. Ishtiaq Ahmed et al.   GENESIS

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

The Genetic Basis of Aortic Aneurysm

(2014) M. E. Lindsay et al.   Cold Spring Harbor Perspectives in Medicine

Biomechanical Phenotyping of Central Arteries in Health and Disease: Advantages of and Methods for Murine Models

(2013) J. Ferruzzi et al.   ANNALS OF BIOMEDICAL ENGINEERING

Observational Cohort Study of Ventricular Arrhythmia in Adults with Marfan Syndrome Caused by FBN1 Mutations

(2013) Ali Aydin et al.   PLoS One

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

TGFB2 mutations cause familial thoracic aortic aneurysms and dissections associated with mild systemic features of Marfan syndrome

(2012) Catherine Boileau et al.   NATURE GENETICS

Transforming growth factor Beta2 is required for valve remodeling during heart development

(2011) Mohamad Azhar et al.   DEVELOPMENTAL DYNAMICS

Generation of mice with a conditional allele for the transforming growth factor beta3 gene

(2011) Thomas Doetschman et al.   GENESIS

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Cellular context-dependent “colors” of transforming growth factor-β signaling

(2009) Hiroaki Ikushima et al.   CANCER SCIENCE