Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

A mutation update on the LDS-associated genes TGFB2/3 and SMAD2/3

(2018) Dorien Schepers et al.   HUMAN MUTATION

Targeting Interleukin-1β Protects from Aortic Aneurysms Induced by Disrupted Transforming Growth Factor β Signaling

(2017) Francesco Da Ros et al.   IMMUNITY

Aetiology and management of hereditary aortopathy

(2017) Aline Verstraeten et al.   Nature Reviews Cardiology

Transforming Growth Factor-β Receptors and Smads: Regulatory Complexity and Functional Versatility

(2017) Erine H. Budi et al.   TRENDS IN CELL BIOLOGY

Transforming Growth Factor‐β in Thoracic Aortic Aneurysms: Good, Bad, or Irrelevant?

(2017) Alan Daugherty et al.   Journal of the American Heart Association

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

(2017) Hao Wei et al.   Journal of the American Heart Association

Hereditary Influence in Thoracic Aortic Aneurysm and Dissection

(2016) Eric M. Isselbacher et al.   CIRCULATION

Loss-of-function mutations in the X-linked biglycan gene cause a severe syndromic form of thoracic aortic aneurysms and dissections

(2016) Josephina A.N. Meester et al.   GENETICS IN MEDICINE

Differential ascending and descending aortic mechanics parallel aneurysmal propensity in a mouse model of Marfan syndrome

(2016) C. Bellini et al.   JOURNAL OF BIOMECHANICS

AT1-receptor blockade, but not renin inhibition, reduces aneurysm growth and cardiac failure in fibulin-4 mice

(2016) Luuk te Riet et al.   JOURNAL OF HYPERTENSION

Signaling Receptors for TGF-β Family Members

(2016) Carl-Henrik Heldin et al.   Cold Spring Harbor Perspectives in Biology

TGF-β Signaling from Receptors to Smads

(2016) Akiko Hata et al.   Cold Spring Harbor Perspectives in Biology

Non-Smad Signaling Pathways of the TGF-β Family

(2016) Ying E. Zhang   Cold Spring Harbor Perspectives in Biology

Regulation of the Bioavailability of TGF-β and TGF-β-Related Proteins

(2016) Ian B. Robertson et al.   Cold Spring Harbor Perspectives in Biology

Embryological Origin of Human Smooth Muscle Cells Influences Their Ability to Support Endothelial Network Formation

(2016) Johannes Bargehr et al.   Stem Cells Translational Medicine

Increased TGF-β Signaling Precedes Aneurysm Formation in SMAD3 Deficient Mice

(2016) Florian S. Schoenhoff   EBioMedicine

Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling

(2016) I. van der Pluijm et al.   EBioMedicine

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions

(2016) Xiaofeng Chen et al.   PLoS One

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in MiceSignificance

(2015) Jie Hong Hu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dimorphic Effects of Transforming Growth Factor-β Signaling During Aortic Aneurysm Progression in Mice Suggest a Combinatorial Therapy for Marfan SyndromeSignificance

(2015) Jason R. Cook et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of Mechanotransduction in Vascular Biology: Focus on Thoracic Aortic Aneurysms and Dissections

(2015) J. D. Humphrey et al.   CIRCULATION RESEARCH

SMAD2Mutations Are Associated with Arterial Aneurysms and Dissections

(2015) Dimitra Micha et al.   HUMAN MUTATION

Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections

(2015) Aida M. Bertoli-Avella et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Embryonic origins of human vascular smooth muscle cells: implications for in vitro modeling and clinical application

(2014) Sanjay Sinha et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibin at 90: From Discovery to Clinical Application, a Historical Review

(2014) Yogeshwar Makanji et al.   ENDOCRINE REVIEWS

Loeys–Dietz syndrome: a primer for diagnosis and management

(2014) Gretchen MacCarrick et al.   GENETICS IN MEDICINE

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation

(2014) Franco Klingberg et al.   JOURNAL OF CELL BIOLOGY

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

(2014) Wei Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Thoracic Aortic Aneurysm and Dissection

(2014) Judith Z. Goldfinger et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Thoracic Aortic Aneurysm in Infancy in Aneurysms-Osteoarthritis Syndrome Due to a NovelSMAD3Mutation: Further Delineation of the Phenotype

(2013) Anita Wischmeijer et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Interpreting Inflammation

(2013) Alexander Awgulewitsch et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Embryological-Origin–Dependent Differences in Homeobox Expression in Adult Aorta

(2013) Laia Trigueros-Motos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Smad2 and Myocardin-Related Transcription Factor B Cooperatively Regulate Vascular Smooth Muscle Differentiation From Neural Crest Cells

(2013) Wei-Bing Xie et al.   CIRCULATION RESEARCH

Conundrum of angiotensin II and TGF-β interactions in aortic aneurysms

(2013) Xiaofeng Chen et al.   CURRENT OPINION IN PHARMACOLOGY

The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling

(2013) Ace E. Lewis et al.   DEVELOPMENTAL BIOLOGY

Losartan reduces aortic dilatation rate in adults with Marfan syndrome: a randomized controlled trial

(2013) M. Groenink et al.   EUROPEAN HEART JOURNAL

Late complications and distal growth rates of Marfan aortas after proximal aortic repair†

(2013) Fabian A. Kari et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis

(2013) Elena M. Gallo et al.   JOURNAL OF CLINICAL INVESTIGATION

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency

(2013) Ping Ye et al.   JOURNAL OF CLINICAL INVESTIGATION

In-Frame Mutations in Exon 1 of SKI Cause Dominant Shprintzen-Goldberg Syndrome

(2012) Virginie Carmignac et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Generation of human vascular smooth muscle subtypes provides insight into embryological origin–dependent disease susceptibility

(2012) Christine Cheung et al.   NATURE BIOTECHNOLOGY

Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm

(2012) Mark E Lindsay et al.   NATURE GENETICS

Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm

(2012) Alexander J Doyle et al.   NATURE GENETICS

Medical Therapy of Thoracic Aortic Aneurysms

(2011) Peter Danyi et al.   CIRCULATION

The Single-Molecule Mechanics of the Latent TGF-β1 Complex

(2011) Lara Buscemi et al.   CURRENT BIOLOGY

TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs

(2011) Tao Huang et al.   EMBO JOURNAL

Novel MYH11 and ACTA2 mutations reveal a role for enhanced TGFβ signaling in FTAAD

(2011) Marjolijn Renard et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Pivotal role of cardiomyocyte TGF-β signaling in the murine pathological response to sustained pressure overload

(2011) Norimichi Koitabashi et al.   JOURNAL OF CLINICAL INVESTIGATION

Lessons on the pathogenesis of aneurysm from heritable conditions

(2011) Mark E. Lindsay et al.   NATURE

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Noncanonical TGF  Signaling Contributes to Aortic Aneurysm Progression in Marfan Syndrome Mice

(2011) T. M. Holm et al.   SCIENCE

Angiotensin II Type 2 Receptor Signaling Attenuates Aortic Aneurysm in Mice Through ERK Antagonism

(2011) J. P. Habashi et al.   SCIENCE

Extracellular regulation of transforming growth factor β and bone morphogenetic protein signaling in bone

(2010) Harikiran Nistala et al.   Annals of the New York Academy of Sciences

Epigenetic control of vascular smooth muscle cells in Marfan and non-Marfan thoracic aortic aneurysms

(2010) Delphine Gomez et al.   CARDIOVASCULAR RESEARCH

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation

(2010) Harikiran Nistala et al.   JOURNAL OF CELL BIOLOGY

TGF-β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II–infused mice

(2010) Yu Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibulin-4 Deficiency Results in Ascending Aortic Aneurysms

(2009) Jianbin Huang et al.   CIRCULATION RESEARCH

Absence of TGFβ signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

(2009) Bibha Choudhary et al.   GENESIS

Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway

(2009) Delphine Gomez et al.   JOURNAL OF PATHOLOGY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Gq-coupled receptors as mechanosensors mediating myogenic vasoconstriction

(2008) Michael Mederos y Schnitzler et al.   EMBO JOURNAL