The transcription factor GATA6 accelerates vascular smooth muscle cell senescence-related arterial calcification by counteracting the role of anti-aging factor SIRT6 and impeding DNA damage repair

Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways

(2023) Wenrun Wu et al.   Redox Biology

Viral mediated knockdown of GATA6 in SMA iPSC ‐derived astrocytes prevents motor neuron loss and microglial activation

(2022) Reilly L. Allison et al.   GLIA

SREBP1c-PARP1 axis tunes anti-senescence activity of adipocytes and ameliorates metabolic imbalance in obesity

(2022) Gung Lee et al.   Cell Metabolism

Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4

(2022) Haiyun Chen et al.   Clinical and Translational Medicine

Indoleamine 2,3-Dioxygenase 1 Deletion–Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification

(2022) Liu Ouyang et al.   CIRCULATION

GATA4 and GATA6 loss-of-expression is associated with extinction of the classical programme and poor outcome in pancreatic ductal adenocarcinoma

(2022) Mónica P de Andrés et al.   GUT

Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair

(2022) Siyi Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

(2022) Hao Xiong et al.   Frontiers in Aging Neuroscience

Low dose radiation upregulates Ras/p38 and NADPH oxidase in mouse colon two months after exposure

(2022) Santosh Kumar et al.   MOLECULAR BIOLOGY REPORTS

Cellular functions of the protein kinase ATM and their relevance to human disease

(2021) Ji-Hoon Lee et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity

(2021) Pengyi Yan et al.   Cell Reports

Loss of SIRT1 in diabetes accelerates DNA damage induced vascular calcification

(2020) Francesca Bartoli-Leonard et al.   CARDIOVASCULAR RESEARCH

Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

(2020) Linyuan Peng et al.   NUCLEIC ACIDS RESEARCH

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification

(2020) Estella Zuccolo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GATA6 promotes epithelial-mesenchymal transition and metastasis through MUC1/β-catenin pathway in cholangiocarcinoma

(2020) Xiang Deng et al.   Cell Death & Disease

Runx2 (Runt-Related Transcription Factor 2) Links the DNA Damage Response to Osteogenic Reprogramming and Apoptosis of Vascular Smooth Muscle Cells

(2020) Andrew M. Cobb et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT6 Protects Smooth Muscle Cells from Senescence and Reduces Atherosclerosis

(2020) Mandy Grootaert et al.   CIRCULATION RESEARCH

Endothelial SIRT6 Is Vital to Prevent Hypertension and Associated Cardiorenal Injury Through Targeting Nkx3.2-GATA5 Signaling

(2019) Jian Guo et al.   CIRCULATION RESEARCH

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

(2019) Xiao Tian et al.   CELL

SIRT6, a Mammalian deacylase with multitasking abilities

(2019) Andrew R Chang et al.   PHYSIOLOGICAL REVIEWS

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling

(2018) Jakob Voelkl et al.   JOURNAL OF CLINICAL INVESTIGATION

High phosphate-induced downregulation of PPARγ contributes to CKD-associated vascular calcification

(2018) Liang Liu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

(2018) Minxian Qian et al.   eLife

Molecular Basis for Dysregulated Activation of NKX2-5 in the Vascular Remodeling of Systemic Sclerosis

(2018) Athina Dritsoula et al.   Arthritis & Rheumatology

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

(2018) Anthony J. Donato et al.   CIRCULATION RESEARCH

TCF7L2 (Transcription Factor 7-Like 2) Regulation of GATA6 (GATA-Binding Protein 6)-Dependent and -Independent Vascular Smooth Muscle Cell Plasticity and Intimal Hyperplasia

(2018) Roshni Srivastava et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interaction between autophagy and senescence is required for dihydroartemisinin to alleviate liver fibrosis

(2017) Zili Zhang et al.   Cell Death & Disease

DNA Damage and Repair in Vascular Disease

(2016) Anna Uryga et al.   Annual Review of Physiology

Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation

(2016) Alex B Wang et al.   EMBO JOURNAL

Histone deacetylase and GATA-binding factor 6 regulate arterial remodeling in angiotensin II-induced hypertension

(2016) Gwi Ran Kim et al.   JOURNAL OF HYPERTENSION

SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity

(2016) Xiaoqiang Tang et al.   Scientific Reports

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition

(2015) Yi Xie et al.   Science Signaling

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition

(2015) Yi Xie et al.   Science Signaling

Small Heterodimer Partner Blocks Cardiac Hypertrophy by Interfering With GATA6 Signaling

(2014) Yoon Seok Nam et al.   CIRCULATION RESEARCH

Medial vascular calcification revisited: review and perspectives

(2014) P. Lanzer et al.   EUROPEAN HEART JOURNAL

GATA transcription factors in vertebrates: evolutionary, structural and functional interplay

(2013) Yanyan Tang et al.   MOLECULAR GENETICS AND GENOMICS

Mechanisms of vascular calcification in CKD—evidence for premature ageing?

(2013) Catherine M. Shanahan   Nature Reviews Nephrology

GATA-6 promotes cell survival by up-regulating BMP-2 expression during embryonic stem cell differentiation

(2012) Li Rong et al.   MOLECULAR BIOLOGY OF THE CELL

The sirtuin SIRT6 regulates lifespan in male mice

(2012) Yariv Kanfi et al.   NATURE

Senescent cells develop a PARP-1 and nuclear factor- B-associated secretome (PNAS)

(2011) M. Ohanna et al.   GENES & DEVELOPMENT

Inhibition of ATM kinase activity does not phenocopy ATM protein disruption

(2010) Serah Choi et al.   CELL CYCLE

Bone Morphogenetic Proteins 2 and 5 Are Down-regulated in Adrenocortical Carcinoma and Modulate Adrenal Cell Proliferation and Steroidogenesis

(2009) I. K. Johnsen et al.   CANCER RESEARCH