Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4

Constitutive activation of ERK1/2 signaling protects against myocardial ischemia via inhibition of mitochondrial fragmentation in the aging heart

(2021) Qiang Zhao et al.   Annals of Translational Medicine

TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

(2020) Haiyun Chen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Gene therapy for inherited arrhythmias

(2020) Vassilios J Bezzerides et al.   CARDIOVASCULAR RESEARCH

Bmi1 Overexpression in Mesenchymal Stem Cells Exerts Anti-Aging and Anti-Osteoporosis Effects by Inactivating p16/p19 Signaling And Inhibiting Oxidative Stress

(2019) Guangpei Chen et al.   STEM CELLS

Autophagy and cardiac aging

(2019) Shigeki Miyamoto   CELL DEATH AND DIFFERENTIATION

Emerging Roles for Polycomb-Group Proteins in Stem Cells and Cancer

(2019) Ho Lam Chan et al.   TRENDS IN BIOCHEMICAL SCIENCES

The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation

(2019) Xin Xie et al.   Science Advances

Stapled Peptides—A Useful Improvement for Peptide-Based Drugs

(2019) Mattia Moiola et al.   MOLECULES

Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4

(2019) Satoru Yamamura et al.   HYPERTENSION

The Polycomb Protein Bmi1 Plays a Crucial Role in the Prevention of 1,25(OH) 2 D Deficiency‐Induced Bone Loss

(2019) Haijian Sun et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The coming of age of chaperone-mediated autophagy

(2018) Susmita Kaushik et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dural effects of oxidative stress on cardiomyogenesis via Gata4 transcription and protein ubiquitination

(2018) Tao Li et al.   Cell Death & Disease

Bmi1 Regulates IκBα Degradation via Association with the SCF Complex

(2018) Yuko Okuyama et al.   JOURNAL OF IMMUNOLOGY

DEAD Box Protein 5 Inhibits Liver Tumorigenesis by Stimulating Autophagy via Interaction with p62/SQSTM1

(2018) Hao Zhang et al.   HEPATOLOGY

Targeting Autophagy in Aging and Aging-Related Cardiovascular Diseases

(2018) Jun Ren et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program

(2017) Anna E. Mazzucco et al.   GENES & DEVELOPMENT

IL11 is a crucial determinant of cardiovascular fibrosis

(2017) Sebastian Schafer et al.   NATURE

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

(2016) Yang Zhou et al.   Cell Stem Cell

Aging and Autophagy in the Heart

(2016) Akihiro Shirakabe et al.   CIRCULATION RESEARCH

Stapled peptide design: principles and roles of computation

(2016) Yaw Sing Tan et al.   DRUG DISCOVERY TODAY

The role of autophagy in angiotensin II-induced pathological cardiac hypertrophy

(2016) Lichun Zhou et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Angiotensin II blockade: how its molecular targets may signal to mitochondria and slow aging. Coincidences with calorie restriction and mTOR inhibition

(2015) Elena M. V. de Cavanagh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

(2015) Z Li et al.   CELL DEATH AND DIFFERENTIATION

Targeting transgene to the heart and liver with AAV9 by different promoters

(2015) Bang-Dang Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

Anti-aging Effect of Transplanted Amniotic Membrane Mesenchymal Stem Cells in a Premature Aging Model of Bmi-1 Deficiency

(2015) Chunfeng Xie et al.   Scientific Reports

Bmi-1 plays a critical role in protection from renal tubulointerstitial injury by maintaining redox balance

(2014) Jianliang Jin et al.   AGING CELL

Targeting inflammation: New therapeutic approaches in chronic kidney disease (CKD)

(2014) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development

(2012) F. Lavial et al.   GENES & DEVELOPMENT

Aging and the Renin-Angiotensin System

(2012) Sara Conti et al.   HYPERTENSION

Mechanism of Ang II involvement in activation of NF-κB through phosphorylation of p65 during aging

(2011) Ji Min Kim et al.   AGE

Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID)

(2011) Mariell Jessup et al.   CIRCULATION

Recognition of UbcH5c and the nucleosome by the Bmi1/Ring1b ubiquitin ligase complex

(2011) Matthew L Bentley et al.   EMBO JOURNAL

An Improved Transplantation Strategy for Mouse Mesenchymal Stem Cells in an Acute Myocardial Infarction Model

(2011) Jianliang Jin et al.   PLoS One

Inhibition of autophagy in the heart induces age-related cardiomyopathy

(2010) Manabu Taneike et al.   Autophagy

Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice

(2009) Heng-Wei Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

The E3 Ubiquitin-Ligase Bmi1/Ring1A Controls the Proteasomal Degradation of Top2α Cleavage Complex – A Potentially New Drug Target

(2009) Iris Alchanati et al.   PLoS One

TNF-α reduces PGC-1α expression through NF-κB and p38 MAPK leading to increased glucose oxidation in a human cardiac cell model

(2008) Xavier Palomer et al.   CARDIOVASCULAR RESEARCH