Endothelial Gata6 deletion reduces monocyte recruitment and proinflammatory macrophage formation and attenuates atherosclerosis through Cmpk2-Nlrp3 pathways

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

Role of myeloid-derived chemokine CCL5/RANTES at an early stage of atherosclerosis

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Targeting the Inflammasome in Cardiovascular Disease

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TWIST1 Drives Smooth Muscle Cell Proliferation in Pulmonary Hypertension via Loss of GATA-6 and BMPR2

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Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation

(2019) Tao Zhuang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Chemokines as Therapeutic Targets in Cardiovascular Disease

(2019) Heidi Noels et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

(2019) Tao Zhuang et al.   CIRCULATION RESEARCH

Endothelial responses to shear stress in atherosclerosis: a novel role for developmental genes

(2019) Celine Souilhol et al.   Nature Reviews Cardiology

Induction of microRNA-10a using retinoic acid receptor-α and retinoid x receptor-α agonists inhibits atherosclerotic lesion formation

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NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

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New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

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Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNFα-induced VCAM-1 expression and monocytic cell adhesion

(2018) Xing Fan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

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MicroRNA-10a is crucial for endothelial response to different flow patterns via interaction of retinoid acid receptors and histone deacetylases

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Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

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Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Monocyte trafficking across the vessel wall

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Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal

(2014) M. Rosas et al.   SCIENCE

Endothelial GATA-6 Deficiency Promotes Pulmonary Arterial Hypertension

(2013) Angela Ghatnekar et al.   AMERICAN JOURNAL OF PATHOLOGY

GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor β/Activin Receptor-like Kinase 5 Signaling

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Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Chemokines in the vascular inflammatory response of atherosclerosis

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A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration

(2008) Yuzhen Zhang et al.   NATURE GENETICS