Elucidating the Mechanism of Multispecific Antibody Aggregation through Subunit Analysis

Exploring frontiers of orbitrap performance for long transients

(2021) Eduard Denisov et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Pre-stage perfusion and ultra-high seeding cell density in CHO fed-batch culture: a case study for process intensification guided by systems biotechnology

(2020) Lisa Stepper et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Process intensification for the production of rituximab by an inducible CHO cell line

(2019) Kahina Mellahi et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Middle-up analysis of monoclonal antibodies after combined IgdE and IdeS hinge proteolysis: Investigation of free sulfhydryls

(2018) Valegh Faid et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Upstream process intensification and continuous manufacturing

(2018) Chun Chen et al.   Current Opinion in Chemical Engineering

Melting Proteins: Evidence for Multiple Stable Structures upon Thermal Denaturation of Native Ubiquitin from Ion Mobility Spectrometry-Mass Spectrometry Measurements

(2017) Tarick J. El-Baba et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improving lactate metabolism in an intensified CHO culture process: productivity and product quality considerations

(2016) Sen Xu et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Native Mass Spectrometry: What is in the Name?

(2016) Aneika C. Leney et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

How Closely Related Are Conformations of Protein Ions Sampled by IM-MS to Native Solution Structures?

(2015) Shu-Hua Chen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry

(2015) Markus Haberger et al.   mAbs

A new tool for monoclonal antibody analysis

(2014) Yan An et al.   mAbs

Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry

(2012) Sara Rosati et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Effective Temperature of Ions in Traveling Wave Ion Mobility Spectrometry

(2011) Denis Morsa et al.   ANALYTICAL CHEMISTRY

Mass Spectrometric Strategies and Their Applications for Molecular Mass Determination of Recombinant Therapeutic Proteins

(2011) Marina Carini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Structural Stability from Solution to the Gas Phase: Native Solution Structure of Ubiquitin Survives Analysis in a Solvent-Free Ion Mobility–Mass Spectrometry Environment

(2011) Thomas Wyttenbach et al.   JOURNAL OF PHYSICAL CHEMISTRY B

How Hot are Your Ions in TWAVE Ion Mobility Spectrometry?

(2011) Samuel I. Merenbloom et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Antibody fragments

(2010) Aaron L. Nelson   mAbs

Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-orbitrap mass spectrometer

(2009) Pavel V. Bondarenko et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Dynamics of ions of intact proteins in the Orbitrap mass analyzer

(2009) Alexander Makarov et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Native mass spectrometry: a bridge between interactomics and structural biology

(2008) Albert J R Heck   NATURE METHODS