Process intensification for the production of rituximab by an inducible CHO cell line

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

Perfusion Cell Culture Decreases Process and Product Heterogeneity in a Head-to-Head Comparison With Fed-Batch

(2018) Jason Walther et al.   Biotechnology Journal

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

(2018) Soo Min Noh et al.   Scientific Reports

Impact of CHO Metabolism on Cell Growth and Protein Production: An Overview of Toxic and Inhibiting Metabolites and Nutrients

(2018) Sara Pereira et al.   Biotechnology Journal

Perfusion Cell Culture Decreases Process and Product Heterogeneity in a Head-to-Head Comparison With Fed-Batch

(2018) Jason Walther et al.   Biotechnology Journal

Process development for an inducible rituximab-expressing Chinese hamster ovary cell line

(2018) Kahina Mellahi et al.   BIOTECHNOLOGY PROGRESS

Rapid protein production from stable CHO cell pools using plasmid vector and the cumate gene-switch

(2017) Adeline Poulain et al.   JOURNAL OF BIOTECHNOLOGY

Altering the central carbon metabolism of HEK293 cells: Impact on recombinant glycoprotein quality

(2017) Eric Karengera et al.   JOURNAL OF BIOTECHNOLOGY

Therapeutic glycoprotein production in mammalian cells

(2017) Marie-Eve Lalonde et al.   JOURNAL OF BIOTECHNOLOGY

The Contrast Enhancement of Intracranial Arterial Wall on High-resolution MRI and Its Clinical Relevance in Patients with Moyamoya Vasculopathy

(2017) Maoxue Wang et al.   Scientific Reports

Mammalian Systems Biotechnology Reveals Global Cellular Adaptations in a Recombinant CHO Cell Line

(2017) Faraaz Noor Khan Yusufi et al.   Cell Systems

Closed loop control of lactate concentration in mammalian cell culture by Raman spectroscopy leads to improved cell density, viability, and biopharmaceutical protein production

(2016) Thomas E. Matthews et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic engineering of CHO cells to alter lactate metabolism during fed-batch cultures

(2016) Cécile Toussaint et al.   JOURNAL OF BIOTECHNOLOGY

Concentrated fed-batch cell culture increases manufacturing capacity without additional volumetric capacity

(2016) William C. Yang et al.   JOURNAL OF BIOTECHNOLOGY

A multi-pronged investigation into the effect of glucose starvation and culture duration on fed-batch CHO cell culture

(2015) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Elucidating the effects of postinduction glutamine feeding on the growth and productivity of CHO cells

(2014) Zahra Sheikholeslami et al.   BIOTECHNOLOGY PROGRESS

Effect of glutamine substitution by TCA cycle intermediates on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

(2014) Tae Kwang Ha et al.   JOURNAL OF BIOTECHNOLOGY

The impact of the timing of induction on the metabolism and productivity of CHO cells in culture

(2013) Zahra Sheikholeslami et al.   BIOCHEMICAL ENGINEERING JOURNAL

Glycosylation: impact, control and improvement during therapeutic protein production

(2013) Ana Rita Costa et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Probing the metabolism of an inducible mammalian expression system using extracellular isotopomer analysis

(2013) Zahra Sheikholeslami et al.   JOURNAL OF BIOTECHNOLOGY

Exploiting the metabolism of PYC expressing HEK293 cells in fed-batch cultures

(2013) Cédric Vallée et al.   JOURNAL OF BIOTECHNOLOGY

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Effect of process change from perfusion to fed-batch on product comparability for biosimilar monoclonal antibody

(2012) Soo-Young Lee et al.   PROCESS BIOCHEMISTRY

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Increasing the productivity of TNFR-Fc in GS-CHO cells at reduced culture temperatures

(2011) Tian-Ci Kou et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Simple and efficient control of CHO cell cultures

(2011) M. Aehle et al.   JOURNAL OF BIOTECHNOLOGY

Enhanced glycoprotein production in HEK-293 cells expressing pyruvate carboxylase

(2011) Olivier Henry et al.   METABOLIC ENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?

(2008) Janet Chusainow et al.   BIOTECHNOLOGY AND BIOENGINEERING

Simpler noninstrumented batch and semicontinuous cultures provide mammalian cell kinetic data comparable to continuous and perfusion cultures

(2008) Olivier Henry et al.   BIOTECHNOLOGY PROGRESS

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Glycosylation of Recombinant Antibody Therapeutics

(2005) Royston Jefferis   BIOTECHNOLOGY PROGRESS

Temperature Reduction in Cultures of hGM-CSF-expressing CHO Cells: Effect on Productivity and Product Quality

(2005) Mariela Bollati-Fogolín et al.   BIOTECHNOLOGY PROGRESS