Furanodiene alters mitochondrial function in doxorubicin-resistant MCF-7 human breast cancer cells in an AMPK-dependent manner

The Warburg effect and drug resistance

(2016) Bhaskar Bhattacharya et al.   BRITISH JOURNAL OF PHARMACOLOGY

Furanodiene enhances the anti-cancer effects of doxorubicin on ERα-negative breast cancer cells in vitro

(2016) Zhang-Feng Zhong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Structure-based discovery of an immunomodulatory inhibitor of TLR1–TLR2 heterodimerization from a natural product-like database

(2015) Zhangfeng Zhong et al.   CHEMICAL COMMUNICATIONS

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

ATP Citrate Lyase (ACLY): A Promising Target for Cancer Prevention and Treatment

(2015) Amrita Khwairakpam et al.   CURRENT DRUG TARGETS

Adenosine triphosphate citrate lyase: Emerging target in the treatment of dyslipidemia

(2015) Hernán N. Lemus et al.   Journal of Clinical Lipidology

Curcumin inhibits proliferation–migration of NSCLC by steering crosstalk between a Wnt signaling pathway and an adherens junction via EGR-1

(2015) Qing-yong Chen et al.   Molecular BioSystems

Dissecting the Dual Role of AMPK in Cancer: From Experimental to Human Studies

(2015) G. Zadra et al.   MOLECULAR CANCER RESEARCH

High glucose promotes gastric cancer chemoresistance in vivo and in vitro

(2015) WEI ZHAO et al.   Molecular Medicine Reports

AMP-activated kinase (AMPK) regulates activity of HER2 and EGFR in breast cancer

(2015) Teraneh Z. Jhaveri et al.   Oncotarget

STAT3-Mediated Metabolic Reprograming in Cellular Transformation and Implications for Drug Resistance

(2015) Valeria Poli et al.   Frontiers in Oncology

Effects of Furanodiene on 95-D Lung Cancer Cells: Apoptosis, Autophagy and G1 Phase Cell Cycle Arrest

(2014) Wen-Shan Xu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Furanodiene, a natural small molecule suppresses metastatic breast cancer cell migration and invasion in vitro

(2014) Zhangfeng Zhong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of ATP Citrate Lyase Induces an Anticancer Effect via Reactive Oxygen Species

(2013) Toshiro Migita et al.   AMERICAN JOURNAL OF PATHOLOGY

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

Metformin reverses multidrug resistance and epithelial–mesenchymal transition (EMT) via activating AMP-activated protein kinase (AMPK) in human breast cancer cells

(2013) Chen Qu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

Furanodiene Presents Synergistic Anti-proliferative Activity With Paclitaxel Via Altering Cell Cycle and Integrin Signaling in 95-D Lung Cancer Cells

(2013) Wen-Shan Xu et al.   PHYTOTHERAPY RESEARCH

ATP citrate lyase knockdown impacts cancer stem cells in vitro

(2013) J-i Hanai et al.   Cell Death & Disease

Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells

(2013) I Dando et al.   Cell Death & Disease

An Emerging Strategy for Cancer Treatment Targeting Aberrant Glycogen Synthase Kinase 3β

(2012) Katsuyoshi Miyashita et al.   Anti-Cancer Agents in Medicinal Chemistry

ATP-citrate lyase: A mini-review

(2012) Melanie Chypre et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells

(2012) Shibin Ai et al.   BRITISH JOURNAL OF PHARMACOLOGY

ATP-Citrate Lyase: A Key Player in Cancer Metabolism

(2012) N. Zaidi et al.   CANCER RESEARCH

Metformin is synthetically lethal with glucose withdrawal in cancer cells

(2012) Javier A. Menendez et al.   CELL CYCLE

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Furanodiene, a Natural Product, Inhibits Breast Cancer Growth Bothin vitroandin vivo

(2012) Zhangfeng Zhong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Furanodiene enhances tamoxifen-induced growth inhibitory activity of ERa-positive breast cancer cells in a PPARγ independent manner

(2012) Zhang-Feng Zhong et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism

(2012) Stephen L. Pinkosky et al.   JOURNAL OF LIPID RESEARCH

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

ATP Citrate Lyase Inhibitors as Novel Cancer Therapeutic Agents

(2012) Xu-Yu Zu et al.   Recent Patents on Anti-Cancer Drug Discovery

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

(2011) D. Grahame Hardie   BIOCHEMICAL SOCIETY TRANSACTIONS

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator

(2011) Kuen-Haur Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells

(2011) Xiuping Chen et al.   PHYTOMEDICINE

Transcription factors that mediate epithelial–mesenchymal transition lead to multidrug resistance by upregulating ABC transporters

(2011) M Saxena et al.   Cell Death & Disease

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

Development of protein kinase activators: AMPK as a target in metabolic disorders and cancer

(2009) S. Fogarty et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Energy Homeostasis and Cancer Prevention: The AMP-Activated Protein Kinase

(2009) J. R. Fay et al.   Cancer Prevention Research

Inactivation of AMPK alters gene expression and promotes growth of prostate cancer cells

(2009) J Zhou et al.   ONCOGENE

Induction of apoptosis by furanodiene in HL60 leukemia cells through activation of TNFR1 signaling pathway

(2008) Enlong Ma et al.   CANCER LETTERS

Glycogen synthase kinase 3β (GSK3β) in tumorigenesis and cancer chemotherapy

(2008) Jia Luo   CANCER LETTERS

AMP-activated protein kinase and human cancer: cancer metabolism revisited

(2008) F P Kuhajda   INTERNATIONAL JOURNAL OF OBESITY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH