Transient endoreplication down-regulates the kinesin-14 HSET and contributes to genomic instability

Functional Reprogramming of Polyploidization in Megakaryocytes

(2015) Marianna Trakala et al.   DEVELOPMENTAL CELL

The expanding implications of polyploidy

(2015) Kevin P. Schoenfelder et al.   JOURNAL OF CELL BIOLOGY

Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution

(2015) Ashley M. Laughney et al.   Cell Reports

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Indispensable pre-mitotic endocycles promote aneuploidy in the Drosophila rectum

(2014) K. P. Schoenfelder et al.   DEVELOPMENT

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

(2014) S. M. Dewhurst et al.   Cancer Discovery

Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells

(2014) Bingqing Zhang et al.   PLoS Genetics

Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability

(2013) C. Hassel et al.   DEVELOPMENT

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Chromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors

(2013) A. D. Silk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy, polyploidy and ploidy reversal in the liver

(2013) Andrew W. Duncan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Knowing when to cut and run: mechanisms that control cytokinetic abscission

(2013) Monica Agromayor et al.   TRENDS IN CELL BIOLOGY

“Two” Much of a Good Thing: Telomere Damage-Induced Genome Doubling Drives Tumorigenesis

(2012) Gianluca Varetti et al.   CANCER CELL

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Endoreplication and polyploidy: insights into development and disease

(2012) D. T. Fox et al.   DEVELOPMENT

Linking abnormal mitosis to the acquisition of DNA damage

(2012) Neil J. Ganem et al.   JOURNAL OF CELL BIOLOGY

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

Canonical and atypical E2Fs regulate the mammalian endocycle

(2012) Hui-Zi Chen et al.   NATURE CELL BIOLOGY

E2F8 is essential for polyploidization in mammalian cells

(2012) Shusil K. Pandit et al.   NATURE CELL BIOLOGY

Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

(2012) Li Zheng et al.   Nature Communications

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Checkpoint Kinase 1 Prevents Cell Cycle Exit Linked to Terminal Cell Differentiation

(2011) Z. Ullah et al.   MOLECULAR AND CELLULAR BIOLOGY

An Image-Based, High-Throughput Screening Assay for Molecules that Induce Excess DNA Replication in Human Cancer Cells

(2011) W. Zhu et al.   MOLECULAR CANCER RESEARCH

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Error-prone polyploid mitosis during normal Drosophila development

(2010) D. T. Fox et al.   GENES & DEVELOPMENT

Dampened activity of E2F1–DP and Myb–MuvB transcription factors in Drosophila endocycling cells

(2010) Shahina B. Maqbool et al.   JOURNAL OF CELL SCIENCE

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Endopolyploidy in irradiated p53-deficient tumour cell lines: Persistence of cell division activity in giant cells expressing Aurora-B kinase

(2008) Jekaterina Erenpreisa et al.   CELL BIOLOGY INTERNATIONAL

Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

(2008) Pierre-Emmanuel Puig et al.   CELL BIOLOGY INTERNATIONAL

Growing evidence of the repopulation of regressed tumours by the division of giant cells

(2008) Denys Wheatley   CELL BIOLOGY INTERNATIONAL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress

(2008) S. Mehrotra et al.   GENES & DEVELOPMENT

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

(2008) Z. Ullah et al.   GENES & DEVELOPMENT

Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules

(2008) Shang Cai et al.   MOLECULAR BIOLOGY OF THE CELL

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE