Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells

Strength in Numbers?

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p53 activity is selectively licensed in the Drosophila stem cell compartment

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Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability

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The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo

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Making big cells: One size does not fit all

(2013) B. R. Calvi   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fundamental differences in endoreplication in mammals andDrosophilarevealed by analysis of endocycling and endomitotic cells

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Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation

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Endoreplication and polyploidy: insights into development and disease

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Atypical E2Fs drive atypical cell cycles

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Canonical and atypical E2Fs regulate the mammalian endocycle

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E2F8 is essential for polyploidization in mammalian cells

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FlyBase: improvements to the bibliography

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Genome-Wide Expression Analysis Identifies a Modulator of Ionizing Radiation-Induced p53-Independent Apoptosis in Drosophila melanogaster

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Mechanisms of transcriptional precision in animal development

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Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression

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The Causes and Consequences of Polyploidy in Normal Development and Cancer

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Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

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Programmed Cell Death in Animal Development and Disease

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Hallmarks of Cancer: The Next Generation

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The EEL-1 ubiquitin ligase promotes DNA damage-induced germ cell apoptosis in C. elegans

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E2 Ligase dRad6 Regulates DMP53 Turnover inDrosophila

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DNA Damage-Induced RORα Is Crucial for p53 Stabilization and Increased Apoptosis

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(2011) Norman Zielke et al.   NATURE

E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila

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Dampened activity of E2F1–DP and Myb–MuvB transcription factors in Drosophila endocycling cells

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Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo

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The DNA Damage Response: Making It Safe to Play with Knives

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Activation of autophagy during cell death requires the engulfment receptor Draper

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Transcriptional Regulation by P53

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Localization and characteristics of DNA underreplication zone in the 75C region of intercalary heterochromatin in Drosophila melanogaster polytene chromosomes

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Acute energy reduction induces caspase-dependent apoptosis and activates p53 in retinal ganglion cells (RGC-5)

(2009) Guang-Yu Li et al.   EXPERIMENTAL EYE RESEARCH

p53-Independent Apoptosis Limits DNA Damage-Induced Aneuploidy

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Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster

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Trim24 targets endogenous p53 for degradation

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The Isoforms of the p53 Protein

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The Regulation of the p53-mediated Stress Response by MDM2 and MDM4

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Heterochromatic Genome Stability Requires Regulators of Histone H3 K9 Methylation

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Regulation of apoptosis of rbf mutant cells during Drosophila development

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Epigenetic Blocking of an Enhancer Region Controls Irradiation-Induced Proapoptotic Gene Expression in Drosophila Embryos

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Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress

(2008) S. Mehrotra et al.   GENES & DEVELOPMENT

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

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Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

E2F and p53 Induce Apoptosis Independently during Drosophila Development but Intersect in the Context of DNA Damage

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