Amyloid dye pairs as spectral sensors for enhanced detection and differentiation of misfolded proteins

The Application of Bio-orthogonality for In Vivo Animal Imaging

(2023) Jun Yang et al.   Chemical & Biomedical Imaging

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

(2022) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy

(2022) Jacob I. Ayers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complex Photophysical Properties of K114 Make for a Versatile Fluorescent Probe for Amyloid Detection

(2021) Anastasiia A. Stepanchuk et al.   ACS Chemical Neuroscience

A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer’s disease with lecanemab, an anti-Aβ protofibril antibody

(2021) Chad J. Swanson et al.   Alzheimers Research & Therapy

Ultrasensitive Detection of Amyloid β Oligomers Based on the “DD–A” FRET Binary Probes and Quadrivalent Cruciform DNA Nanostructure-Mediated Cascaded Amplifier

(2021) Yuanyuan Zhang et al.   ACS Applied Materials & Interfaces

Living with the enemy: from protein-misfolding pathologies we know, to those we want to know

(2021) Abdul-Hamid Emwas et al.   AGEING RESEARCH REVIEWS

Spectral photokinetic conversion of the fluorescent probes BSB and K114 for improved detection of amyloid assemblies

(2021) Anastasiia A. Stepanchuk et al.   Journal of Biophotonics

Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

(2021) Ofek Oren et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Fӧrster resonance energy transfer between Thioflavin T and unsymmetrical trimethine cyanine dyes on amyloid fibril scaffold

(2021) Olga Zhytniakivska et al.   CHEMICAL PHYSICS LETTERS

Quantitative detection of grey and white matter amyloid pathology using a combination of K114 and CRANAD-3 fluorescence

(2021) Anastasiia A. Stepanchuk et al.   NEUROBIOLOGY OF DISEASE

A FRET pair for quantitative and superresolution imaging of amyloid fibril formation

(2021) Álvaro Ruiz-Arias et al.   SENSORS AND ACTUATORS B-CHEMICAL

Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease

(2021) Stefania Forner et al.   Scientific Data

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

(2020) Jing Yang et al.   Nature Communications

The Amyloid Phenomenon and Its Significance in Biology and Medicine

(2019) Christopher M. Dobson et al.   Cold Spring Harbor Perspectives in Biology

Interrogating Amyloid Aggregates using Fluorescent Probes

(2019) Amir Aliyan et al.   CHEMICAL REVIEWS

Two-step FRET as a tool for probing the amyloid state of proteins

(2019) Galyna Gorbenko et al.   JOURNAL OF MOLECULAR LIQUIDS

α-Synuclein strains target distinct brain regions and cell types

(2019) Angus Lau et al.   NATURE NEUROSCIENCE

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

Prions, prionoids and protein misfolding disorders

(2018) Claudia Scheckel et al.   NATURE REVIEWS GENETICS

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease

(2018) Carlo Condello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tau monomer encodes strains

(2018) Apurwa M Sharma et al.   eLife

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer’s disease

(2017) Jay Rasmussen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel trans-Stilbene-based Fluorophores as Probes for Spectral Discrimination of Native and Protofibrillar Transthyretin

(2016) Raúl I Campos et al.   ACS Chemical Neuroscience

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Highly Sensitive FRET-FCS Detects Amyloid β-Peptide Oligomers in Solution at Physiological Concentrations

(2015) Stefan Wennmalm et al.   ANALYTICAL CHEMISTRY

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Sensitive and rapid assessment of amyloid by oligothiophene fluorescence in subcutaneous fat tissue

(2014) Daniel Sjölander et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

(2014) Hualong Fu et al.   CHEMICAL COMMUNICATIONS

Pentameric Thiophene-Based Ligands that Spectrally Discriminate Amyloid-β and Tau Aggregates Display Distinct Solvatochromism and Viscosity-Induced Spectral Shifts

(2014) Rozalyn A. Simon et al.   CHEMISTRY-A EUROPEAN JOURNAL

Spectral correlation analysis of Amyloid β plaque inhomogeneity from double staining experiments

(2013) Pål Gunnar Ellingsen et al.   JOURNAL OF BIOMEDICAL OPTICS

Enhanced Fluorescent Assignment of Protein Aggregates by an Oligothiophene-Porphyrin-Based Amyloid Ligand

(2013) Katriann Arja et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

Spectroscopic characterization of diverse amyloid fibrils in vitro by the fluorescent dye Nile red

(2011) Rajesh Mishra et al.   Molecular BioSystems

Non-Conjugated Small Molecule FRET for Differentiating Monomers from Higher Molecular Weight Amyloid Beta Species

(2011) Chongzhao Ran et al.   PLoS One