Amyloid β structural polymorphism, associated toxicity and therapeutic strategies

Curcumin: A small molecule with big functionality against amyloid aggregation in neurodegenerative diseases and type 2 diabetes

(2021) Shabnam Radbakhsh et al.   BIOFACTORS

Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells

(2020) Eri Takada et al.   ACS Chemical Neuroscience

Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content

(2020) Thomas Wiglenda et al.   JOURNAL OF MOLECULAR BIOLOGY

Aβ42 Double Mutant Inhibits Aβ42-Induced Plasma and Mitochondrial Membrane Disruption in Artificial Membranes, Isolated Organs, and Intact Cells

(2020) Ofek Oren et al.   ACS Chemical Neuroscience

Curcumin in Health and Diseases: Alzheimer’s Disease and Curcumin Analogues, Derivatives, and Hybrids

(2020) Eirini Chainoglou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elucidating the Molecular Determinants of Αβ Aggregation with Deep Mutational Scanning

(2019) Vanessa E. Gray et al.   G3-Genes Genomes Genetics

Structural mapping of oligomeric intermediates in an amyloid assembly pathway

(2019) Theodoros K Karamanos et al.   eLife

ATP Converts Aβ42 Oligomer into Off-Pathway Species by Making Contact with Its Backbone Atoms Using Hydrophobic Adenosine

(2019) Ikuo Kurisaki et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The initial stage of structural transformation of Aβ42 peptides from the human and mole rat in the presence of Fe2+ and Fe3+: Related to Alzheimer's disease

(2019) Mohammad Vahed et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

The on-fibrillation-pathway membrane content leakage and off-fibrillation-pathway lipid mixing induced by 40-residue β-amyloid peptides in biologically relevant model liposomes

(2018) Qinghui Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Not Oligomers but Amyloids are Cytotoxic in the Membrane-Mediated Amyloidogenesis of Amyloid-β Peptides

(2018) Naoya Itoh et al.   CHEMBIOCHEM

Conformational Dynamics and Stability of U-Shaped and S-Shaped Amyloid β Assemblies

(2018) Gianvito Grasso et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer’s Disease

(2018) P. Hemachandra Reddy et al.   JOURNAL OF ALZHEIMERS DISEASE

The contribution of biophysical and structural studies of protein self-assembly to the design of therapeutic strategies for amyloid diseases

(2018) Nunilo Cremades et al.   NEUROBIOLOGY OF DISEASE

An Aβ42 variant that inhibits intra- and extracellular amyloid aggregation and enhances cell viability

(2018) Ofek Oren et al.   BIOCHEMICAL JOURNAL

Influence of Zeolites on Amyloid-β Aggregation

(2018) Michael J. Lucas et al.   LANGMUIR

An Engineered Variant of the B1 Domain of Protein G Suppresses the Aggregation and Toxicity of Intra- and Extracellular Aβ42

(2018) Victor Banerjee et al.   ACS Chemical Neuroscience

CuII Binding to Various Forms of Amyloid-β Peptides: Are They Friends or Foes?

(2017) Valentina Borghesani et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Pathways of cellular proteostasis in aging and disease

(2017) Courtney L. Klaips et al.   JOURNAL OF CELL BIOLOGY

Molecular Mechanism for the (−)-Epigallocatechin Gallate-Induced Toxic to Nontoxic Remodeling of Aβ Oligomers

(2017) Rashik Ahmed et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Foldamer-Mediated Structural Rearrangement Attenuates Aβ Oligomerization and Cytotoxicity

(2017) Sunil Kumar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Glucose directs amyloid-beta into membrane-active oligomers

(2017) Niraja Kedia et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Assemblies of amyloid-β30–36 hexamer and its G33V/L34T mutants by replica-exchange molecular dynamics simulation

(2017) Zhenyu Qian et al.   PLoS One

ATP as a biological hydrotrope

(2017) Avinash Patel et al.   SCIENCE

Cross-seeding between Aβ40 and Aβ42 in Alzheimer's disease

(2016) Joyce Tran et al.   FEBS LETTERS

Amyloid β-Protein Assembly and Alzheimer’s Disease: Dodecamers of Aβ42, but Not of Aβ40, Seed Fibril Formation

(2016) Nicholas J. Economou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fe2+binding on amyloid β-peptide promotes aggregation

(2016) Subramaniam Boopathi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway

(2016) Pinaki Misra et al.   Nature Communications

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Toxicity Inhibitors Protect Lipid Membranes from Disruption by Aβ42

(2015) Ravit Malishev et al.   ACS Chemical Neuroscience

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

(2015) Arjun Thapa et al.   ACS Chemical Neuroscience

Interaction of Aβ1–42 Amyloids with Lipids Promotes “Off-Pathway” Oligomerization and Membrane Damage

(2015) Sarah Henry et al.   BIOMACROMOLECULES

A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms

(2015) Jeffrey S. Derrick et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

MRZ-99030 – A novel modulator of Aβ aggregation: I – Mechanism of action (MoA) underlying the potential neuroprotective treatment of Alzheimer's disease, glaucoma and age-related macular degeneration (AMD)

(2015) Christopher G. Parsons et al.   NEUROPHARMACOLOGY

MRZ-99030 – A novel modulator of Aβ aggregation: II – Reversal of Aβ oligomer-induced deficits in long-term potentiation (LTP) and cognitive performance in rats and mice

(2015) Gerhard Rammes et al.   NEUROPHARMACOLOGY

Effects of green tea consumption on cognitive dysfunction in an elderly population: a randomized placebo-controlled study

(2015) Kazuki Ide et al.   Nutrition Journal

Exploring the Alzheimer amyloid-β peptide conformational ensemble: A review of molecular dynamics approaches

(2015) Linh Tran et al.   PEPTIDES

A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

(2015) Michael W. Beck et al.   Chemical Science

How Do Membranes Initiate Alzheimer’s Disease? Formation of Toxic Amyloid Fibrils by the Amyloid β-Protein on Ganglioside Clusters

(2014) Katsumi Matsuzaki   ACCOUNTS OF CHEMICAL RESEARCH

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

(2014) Yu-Jen Chang et al.   FEBS Journal

Kinetic Intermediates in Amyloid Assembly

(2014) Chen Liang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Deep mutational scanning: a new style of protein science

(2014) Douglas M Fowler et al.   NATURE METHODS

Measuring the activity of protein variants on a large scale using deep mutational scanning

(2014) Douglas M Fowler et al.   Nature Protocols

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative analysis of the time course of Aβ oligomerization and subsequent growth steps using tetramethylrhodamine-labeled Aβ

(2013) Kanchan Garai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid β-protein oligomers and Alzheimer’s disease

(2013) Eric Y Hayden et al.   Alzheimers Research & Therapy

Synthetic foldamers

(2011) Gilles Guichard et al.   CHEMICAL COMMUNICATIONS

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

Polymorphism in Alzheimer Aβ Amyloid Organization Reflects Conformational Selection in a Rugged Energy Landscape

(2010) Yifat Miller et al.   CHEMICAL REVIEWS

EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity

(2010) Jan Bieschke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibrillar Oligomers Nucleate the Oligomerization of Monomeric Amyloid β but Do Not Seed Fibril Formation

(2009) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterizing the Appearance and Growth of Amyloid Plaques in APP/PS1 Mice

(2009) P. Yan et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

(2009) Summer L. Bernstein et al.   Nature Chemistry

Structure-neurotoxicity relationships of amyloid  -protein oligomers

(2009) K. Ono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive-Performance Recovery of Alzheimer's Disease Model Mice by Modulation of Early Soluble Amyloidal Assemblies

(2008) Anat Frydman-Marom et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Ratio of Monomeric to Aggregated Forms of Aβ40 and Aβ42 Is an Important Determinant of Amyloid-β Aggregation, Fibrillogenesis, and Toxicity

(2008) Asad Jan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

(2008) Dagmar E Ehrnhoefer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct characterization of amyloidogenic oligomers by single-molecule fluorescence

(2008) A. Orte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA