Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNS

Myelination generates aberrant ultrastructure that is resolved by microglia

(2022) Minou Djannatian et al.   JOURNAL OF CELL BIOLOGY

Microglia regulate central nervous system myelin growth and integrity

(2022) Niamh B. McNamara et al.   NATURE

Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

(2021) Isidora Paredes et al.   NATURE NEUROSCIENCE

Multiple sclerosis risk gene Mertk is required for microglial activation and subsequent remyelination

(2021) Kimberle Shen et al.   Cell Reports

Microglial neuropilin-1 promotes oligodendrocyte expansion during development and remyelination by trans-activating platelet-derived growth factor receptor

(2021) Amin Sherafat et al.   Nature Communications

Fractalkine signaling regulates oligodendroglial cell genesis from SVZ precursor cells

(2021) Adrianne E.S. Watson et al.   Stem Cell Reports

Endogenous neural stem cells modulate microglia and protect against demyelination

(2021) Béatrice Brousse et al.   Stem Cell Reports

Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis

(2020) Maria Inês Cunha et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Microglia phagocytose myelin sheaths to modify developmental myelination

(2020) Alexandria N. Hughes et al.   NATURE NEUROSCIENCE

Neural stem cells of the subventricular zone contribute to neuroprotection of the corpus callosum after cuprizone-induced demyelination

(2019) Erica Butti et al.   JOURNAL OF NEUROSCIENCE

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

The TAM receptor TYRO3 is a critical regulator of myelin thickness in the central nervous system

(2018) Farrah Blades et al.   GLIA

Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

(2018) Qingyun Li et al.   NEURON

Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure

(2017) Alex K. Ray et al.   GLIA

An environment-dependent transcriptional network specifies human microglia identity

(2017) David Gosselin et al.   SCIENCE

Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

(2017) Nicolas Snaidero et al.   Cell Reports

Transient hypothyroidism favors oligodendrocyte generation providing functional remyelination in the adult mouse brain

(2017) Sylvie Remaud et al.   eLife

MerTK Is a Functional Regulator of Myelin Phagocytosis by Human Myeloid Cells

(2016) Luke M. Healy et al.   JOURNAL OF IMMUNOLOGY

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

(2016) Marie-Theres Weil et al.   Cell Reports

Common and Low Frequency Variants in MERTK Are Independently Associated with Multiple Sclerosis Susceptibility with Discordant Association Dependent upon HLA-DRB1*15:01 Status

(2016) Michele D. Binder et al.   PLoS Genetics

Remyelination by Resident Oligodendrocyte Precursor Cells in a Xenopus laevis Inducible Model of Demyelination

(2015) Sowmya Sekizar et al.   DEVELOPMENTAL NEUROSCIENCE

The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity

(2015) Jonathan J Miner et al.   NATURE MEDICINE

Targeted GAS6 Delivery to the CNS Protects Axons from Damage during Experimental Autoimmune Encephalomyelitis

(2014) Ross C. Gruber et al.   JOURNAL OF NEUROSCIENCE

Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination

(2014) Y. L. Xing et al.   JOURNAL OF NEUROSCIENCE

TAM Receptors Support Neural Stem Cell Survival, Proliferation and Neuronal Differentiation

(2014) Rui Ji et al.   PLoS One

TAM Receptors Affect Adult Brain Neurogenesis by Negative Regulation of Microglial Cell Activation

(2013) R. Ji et al.   JOURNAL OF IMMUNOLOGY

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction

(2012) G. Zizzo et al.   JOURNAL OF IMMUNOLOGY

Live Imaging of Targeted Cell Ablation in Xenopus: A New Model to Study Demyelination and Repair

(2012) F. Kaya et al.   JOURNAL OF NEUROSCIENCE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Polymorphisms in the Receptor Tyrosine Kinase MERTK Gene Are Associated with Multiple Sclerosis Susceptibility

(2011) Gerry Z. M. Ma et al.   PLoS One

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

TAM Receptor Signalling and Demyelination

(2009) Michele D. Binder et al.   NEUROSIGNALS

Axl−/− mice have delayed recovery and prolonged axonal damage following cuprizone toxicity

(2008) Hannah J. Hoehn et al.   BRAIN RESEARCH

Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-Induced Demyelination

(2008) M. D. Binder et al.   JOURNAL OF NEUROSCIENCE