Loss of Gas6 and Axl signaling results in extensive axonal damage, motor deficits, prolonged neuroinflammation, and less remyelination following cuprizone exposure

Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination

(2017) Verena Schultz et al.   GLIA

The TAM receptor Tyro3 regulates myelination in the central nervous system

(2017) Rainer Akkermann et al.   GLIA

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease

(2017) Zhuoran Yin et al.   NEUROBIOLOGY OF AGING

Gas6 Promotes Oligodendrogenesis and Myelination in the Adult Central Nervous System and After Lysolecithin-Induced Demyelination

(2016) Salman Goudarzi et al.   ASN Neuro

Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation

(2016) Filip Petković et al.   GLIA

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Axl-EGFR receptor tyrosine kinase hetero-interaction provides EGFR with access to pro-invasive signalling in cancer cells

(2016) M Vouri et al.   Oncogenesis

Role of autophagy in the pathogenesis of multiple sclerosis

(2015) Peizhou Liang et al.   Neuroscience Bulletin

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Targeted GAS6 Delivery to the CNS Protects Axons from Damage during Experimental Autoimmune Encephalomyelitis

(2014) Ross C. Gruber et al.   JOURNAL OF NEUROSCIENCE

Motor skill learning requires active central myelination

(2014) I. A. McKenzie et al.   SCIENCE

Memantine Protects Rats Treated with Intrathecal Methotrexate from Developing Spatial Memory Deficits

(2013) P. D. Cole et al.   CLINICAL CANCER RESEARCH

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Myelin debris regulates inflammatory responses in an experimental demyelination animal model and multiple sclerosis lesions

(2012) Tim Clarner et al.   GLIA

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis

(2011) Jason G Weinger et al.   Journal of Neuroinflammation

Gas6 Increases Myelination by Oligodendrocytes and Its Deficiency Delays Recovery following Cuprizone-Induced Demyelination

(2011) Michele D. Binder et al.   PLoS One

Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor

(2010) D. Zhu et al.   BLOOD

Role of Cytokines as Mediators and Regulators of Microglial Activity in Inflammatory Demyelination of the CNS

(2010) Tobias D. Merson et al.   NEUROMOLECULAR MEDICINE

Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine

(2010) Yan Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

GAS6 Enhances Repair Following Cuprizone-Induced Demyelination

(2010) Vladislav Tsiperson et al.   PLoS One

Up-Regulation of Soluble Axl and Mer Receptor Tyrosine Kinases Negatively Correlates with Gas6 in Established Multiple Sclerosis Lesions

(2009) Jason G. Weinger et al.   AMERICAN JOURNAL OF PATHOLOGY

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats

(2009) Yan Li et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

Axl−/− mice have delayed recovery and prolonged axonal damage following cuprizone toxicity

(2008) Hannah J. Hoehn et al.   BRAIN RESEARCH

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

(2008) Mark P. Marriott et al.   GLIA

Gas6 Deficiency Increases Oligodendrocyte Loss and Microglial Activation in Response to Cuprizone-Induced Demyelination

(2008) M. D. Binder et al.   JOURNAL OF NEUROSCIENCE