Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures

QPROT: Statistical method for testing differential expression using protein-level intensity data in label-free quantitative proteomics

(2015) Hyungwon Choi et al.   Journal of Proteomics

Pediatric Vaccine Adjuvants

(2015) David J. Dowling et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Systems vaccinology: a promise for the young and the poor

(2015) N. Amenyogbe et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes

(2015) Lakshmi Ganapathi et al.   PLoS One

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(2014) John S. Tsang et al.   CELL

Shortcomings of pertussis vaccines: why we need a third generation vaccine

(2014) Jan T Poolman   Expert Review of Vaccines

Glioma-associated microglial MMP9 expression is upregulated by TLR2 signaling and sensitive to minocycline

(2014) Feng Hu et al.   INTERNATIONAL JOURNAL OF CANCER

Elimination of the cold-chain dependence of a nanoemulsion adjuvanted vaccine against tuberculosis by lyophilization

(2014) Mark T. Orr et al.   JOURNAL OF CONTROLLED RELEASE

The Adjuvants Aluminum Hydroxide and MF59 Induce Monocyte and Granulocyte Chemoattractants and Enhance Monocyte Differentiation toward Dendritic Cells

(2014) A. Seubert et al.   JOURNAL OF IMMUNOLOGY

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Ontogeny of early life immunity

(2014) David J. Dowling et al.   TRENDS IN IMMUNOLOGY

Soluble Mediators Regulating Immunity in Early Life

(2014) Matthew Aaron Pettengill et al.   Frontiers in Immunology

Particulate Adjuvant and Innate Immunity: Past Achievements, Present Findings, and Future Prospects

(2013) Etsushi Kuroda et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine

(2013) Matthew Pettengill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cathepsin-mediated Necrosis Controls the Adaptive Immune Response by Th2 (T helper type 2)-associated Adjuvants

(2013) Lee S. Jacobson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

(2013) Shuzhao Li et al.   NATURE IMMUNOLOGY

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Safety and Immunogenicity of Neonatal Pneumococcal Conjugate Vaccination in Papua New Guinean Children: A Randomised Controlled Trial

(2013) William S. Pomat et al.   PLoS One

The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

(2013) David J. Dowling et al.   PLoS One

Direct Proteomic Quantification of the Secretome of Activated Immune Cells

(2013) F. Meissner et al.   SCIENCE

Mosquirix (RTS,S): A Novel Vaccine for the Prevention of Plasmodium falciparum Malaria

(2012) K. J. Wilby et al.   ANNALS OF PHARMACOTHERAPY

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

(2012) M. Kwissa et al.   BLOOD

The Mechanism of Adjuvanticity of Aluminium-Containing Formulas

(2012) Kaat Fierens et al.   CURRENT PHARMACEUTICAL DESIGN

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Adjuvanted pandemic influenza vaccine: variation of emulsion components affects stability, antigen structure, and vaccine efficacy

(2012) Christopher B. Fox et al.   Influenza and Other Respiratory Viruses

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

(2012) Victoria J. Philbin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Neonatal Plasma Polarizes TLR4-Mediated Cytokine Responses towards Low IL-12p70 and High IL-10 Production via Distinct Factors

(2012) Mirjam E. Belderbos et al.   PLoS One

Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo

(2012) Marina Zaitseva et al.   VACCINE

Immune response to vaccine adjuvants during the first year of life

(2012) Ofer Levy et al.   VACCINE

Matrix Metalloprotease 9 Mediates Neutrophil Migration into the Airways in Response to Influenza Virus-Induced Toll-Like Receptor Signaling

(2012) Linda M. Bradley et al.   PLoS Pathogens

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Alum adjuvant: some of the tricks of the oldest adjuvant

(2011) M. Kool et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Integrated Proteomic Profiling of Cell Line Conditioned Media and Pancreatic Juice for the Identification of Pancreatic Cancer Biomarkers

(2011) Shalini Makawita et al.   MOLECULAR & CELLULAR PROTEOMICS

Challenges in infant immunity: implications for responses to infection and vaccines

(2011) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Systems biology of vaccination for seasonal influenza in humans

(2011) Helder I Nakaya et al.   NATURE IMMUNOLOGY

Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

(2011) Joanne G. Lisciandro et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Development of Newborn and Infant Vaccines

(2011) G. Sanchez-Schmitz et al.   Science Translational Medicine

The safety evaluation of adjuvants during vaccine development: The AS04 experience

(2011) Nathalie Garçon et al.   VACCINE

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Expression of Genes Associated with Immunoproteasome Processing of Major Histocompatibility Complex Peptides Is Indicative of Protection with Adjuvanted RTS,S Malaria Vaccine

(2010) Maryanne T. Vahey et al.   JOURNAL OF INFECTIOUS DISEASES

Differential Effect of TLR2 and TLR4 on the Immune Response after Immunization with a Vaccine against Neisseria meningitidis or Bordetella pertussis

(2010) Floris Fransen et al.   PLoS One

Immunology of TLR-independent vaccine adjuvants

(2009) Ennio De Gregorio et al.   CURRENT OPINION IN IMMUNOLOGY

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

Randomized, Double‐Blind, Phase 2a Trial of Falciparum Malaria Vaccines RTS,S/AS01B and RTS,S/AS02A in Malaria‐Naive Adults: Safety, Efficacy, and Immunologic Associates of Protection

(2009) Kent E. Kester et al.   JOURNAL OF INFECTIOUS DISEASES

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Transplacental transfer of filarial antigens from Wuchereria bancrofti-infected mothers to their offspring

(2009) M. S. BAL et al.   PARASITOLOGY

Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

(2009) Anita. H.J. van den Biggelaar et al.   VACCINE

Significance Analysis of Spectral Count Data in Label-free Shotgun Proteomics

(2008) Hyungwon Choi et al.   MOLECULAR & CELLULAR PROTEOMICS

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Molecular and cellular signatures of human vaccine adjuvants

(2008) F. Mosca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactogenicity of infant whole cell pertussis combination vaccine compared with acellular pertussis vaccines with or without simultaneous pneumococcal vaccine in the Netherlands

(2008) Silke David et al.   VACCINE

Analysis of adverse events of potential autoimmune aetiology in a large integrated safety database of AS04 adjuvanted vaccines

(2008) Thomas Verstraeten et al.   VACCINE