Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 18, Issue 16, Pages 2305-2313Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161212800166004
Keywords
Adjuvant; aluminium hydroxide; dendritic cell; NLRP3; Syk; uric acid and dsDNA
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Vaccinations have been given to people for at least 100 years of which 80 years formulated in adjuvants. Currently, aluminium-containing formulas and the oil-based substance called MF59 are the two adjuvants licensed for clinical use. Despite the massive use of aluminium adjuvant, its mechanism of action has been only recently addressed. In this review, we will discuss both the cellular and molecular mode of action of aluminium-containing adjuvants.
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