The Ultra-Potent and Selective TLR8 Agonist VTX-294 Activates Human Newborn and Adult Leukocytes

Deficient TACI Expression on B Lymphocytes of Newborn Mice Leads to Defective Ig Secretion in Response to BAFF or APRIL

(2014) S. Kanswal et al.   JOURNAL OF IMMUNOLOGY

Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates

(2012) M. Kwissa et al.   BLOOD

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1–dependent pathways

(2012) Victoria J. Philbin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction

(2012) Ce Shi et al.   ACS Medicinal Chemistry Letters

Toll-like receptors

(2011) Eva Marie Y. Moresco et al.   CURRENT BIOLOGY

VTX-1463, a novel TLR8 agonist for the treatment of allergic rhinitis

(2011) Friedrich Horak   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Adenosine modulates Toll-like receptor function: basic mechanisms and translational opportunities

(2011) Melanie R Power Coombs et al.   Expert Review of Anti-Infective Therapy

TLR-7 and -8 agonists as vaccine adjuvants

(2011) Mark A Tomai et al.   Expert Review of Vaccines

Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody

(2011) M. Luiza-Silva et al.   JOURNAL OF INFECTIOUS DISEASES

Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia: 4-year end-of-study analysis of the randomised, double-blind PATRICIA trial

(2011) Matti Lehtinen et al.   LANCET ONCOLOGY

Challenges in infant immunity: implications for responses to infection and vaccines

(2011) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Immunological mechanisms of vaccination

(2011) Bali Pulendran et al.   NATURE IMMUNOLOGY

First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children

(2011)   NEW ENGLAND JOURNAL OF MEDICINE

Age-Dependent Maturation of Toll-Like Receptor-Mediated Cytokine Responses in Gambian Infants

(2011) Sarah Burl et al.   PLoS One

Comparative Analysis of Species-Specific Ligand Recognition in Toll-Like Receptor 8 Signaling: A Hypothesis

(2011) Rajiv Gandhi Govindaraj et al.   PLoS One

UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling

(2011) Hiroki Itoh et al.   PLoS One

Phagosomal signaling byBorrelia burgdorferiin human monocytes involves Toll-like receptor (TLR) 2 and TLR8 cooperativity and TLR8-mediated induction of IFN-β

(2011) Jorge L. Cervantes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of Newborn and Infant Vaccines

(2011) G. Sanchez-Schmitz et al.   Science Translational Medicine

Vaccine adjuvant activity of 3M-052: An imidazoquinoline designed for local activity without systemic cytokine induction

(2011) Dmitri Smirnov et al.   VACCINE

Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models

(2010) Jennifer D. Hood et al.   Human vaccines & immunotherapeutics

Vaccine Adjuvants: Putting Innate Immunity to Work

(2010) Robert L. Coffman et al.   IMMUNITY

Use of defined TLR ligands as adjuvants within human vaccines

(2010) Malcolm S. Duthie et al.   IMMUNOLOGICAL REVIEWS

Assessing the immunopotency of Toll-like receptor agonists in anin vitrotissue-engineered immunological model

(2010) Yifan Ma et al.   IMMUNOLOGY

Profound Lack of Interleukin (IL)–12/IL‐23p40 in Neonates Born Early in Gestation Is Associated with an Increased Risk of Sepsis

(2010) Pascal M. Lavoie et al.   JOURNAL OF INFECTIOUS DISEASES

Expression of Toll-like receptors by neonatal leukocytes

(2010) Pallave Dasari et al.   PEDIATRIC ALLERGY AND IMMUNOLOGY

Ontogeny of Toll-Like Receptor Mediated Cytokine Responses of Human Blood Mononuclear Cells

(2010) Nathan P. Corbett et al.   PLoS One

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Developmental Biology of the Innate Immune Response: Implications for Neonatal and Infant Vaccine Development

(2009) Victoria Jane Philbin et al.   PEDIATRIC RESEARCH

Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: A randomized controlled trial in Papua New Guinea

(2009) Anita. H.J. van den Biggelaar et al.   VACCINE

Safety and efficacy of neonatal vaccination

(2008) Alicia Demirjian et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans

(2008) Troy D Querec et al.   NATURE IMMUNOLOGY

Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

(2008) Sonia Davila et al.   PLoS Genetics